Letrozole: When will I start feeling/seeing side effects?

Yes it's not fun. Bit curious why anastrozole seems the drug of choice here in Australia.

I meant I wasn't just willing to blame Old Age. I'm sticking with letrozole for pretty much the same reason as you: Stage 3A lobular cancer which was missed on previous mammograms and found this time because of more than 4 cancerous lymph nodes. I'll put up with the stiffness to ward off the monster.

So what's the alternative? Going off AIs and just hoping your cancer will not return? In my case, an aggressive grade 3 hormone fed cancer had APPARENTLY not escaped into my lymphatic system, as shown by a PET scan. But there is no way to be certain. It's a known unknown.

Not buying it ;‐)
I am 77 ( married to a now-retired chiropractor ) and had zero of those joint stiffness issues before chemo and letrozole.
I'll blame old age for the arthritis in my thumbs but that's it.

Same here. But I wonder how much is caused by the AI, and how much by what my parents called BOA - Bloody Old Age. I'm nearly 77. Apparently everyone over 40 has some degree of arthritis. Still have three years to go on anastrozole.

I very seldom have hot flashes. My main side effect is joint stiffness which took several months to manifest. It's especially bad when I first wake up in the morning. Sometimes I lie awake for a while summoning the strength to move, but once I am up and about moving around the stiffness nearly goes away.

When I was on letrozole the first month was great ! Then by the end of third month felt horrible.. body aches, joint pain & severe hand pain had to see a hand surgeon… stopped all these pills entirely.. even my oncologist radiologist said most not all people can’t tolerate these pills also said they do have bad side effects .. I’m off for now not sure I am going to start back if I do only going to take either every other day or probably 3 X a week.. ❤️

Same here. Certainly a lot more fatigue than before chemo and radio, but other things to blame - peripheral neuropathy and just getting older.

Letrozole makes my joints ache—knees, hands worst. I take arthritis strength acetaminophen which helps a lot. I deal with it. It’s been almost 6 mos now. Could be worse.

I am so sorry to hear about the journey you have had with Letrozole and Faslodex. Are you taking any meds at all for your breast cancer/remission? Are you slowly getting movement back?