Hemodialysis International

Volume 17, Issue 2 p. 275-281

Original Article

Effects of flaxseed consumption on systemic inflammation and serum lipid profile in hemodialysis patients with lipid abnormalities

Saman Khalatbari Soltani,

Saman Khalatbari Soltani

Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia

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Rosita Jamaluddin,

Corresponding Author

Rosita Jamaluddin

Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia

Correspondence to: R. Jamaluddin, PhD, Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia. E-mail: [email protected]Search for more papers by this author

Hadi Tabibi,

Hadi Tabibi

Department of Clinical Nutrition & Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Islamic Republic of Iran

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Barakatun Nisak Mohd Yusof,

Barakatun Nisak Mohd Yusof

Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia

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Shahnaz Atabak,

Shahnaz Atabak

Department of Nephrology, Shahid Modares Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran

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Su-Peng Loh,

Su-Peng Loh

Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia

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Leila Rahmani,

Leila Rahmani

Peritoneal Dialysis Ward, Shahid Modares Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran

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Saman Khalatbari Soltani,

Saman Khalatbari Soltani

Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia

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Rosita Jamaluddin,

Corresponding Author

Rosita Jamaluddin

Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia

Hadi Tabibi,

Hadi Tabibi

Department of Clinical Nutrition & Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Islamic Republic of Iran

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Barakatun Nisak Mohd Yusof,

Barakatun Nisak Mohd Yusof

Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia

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Shahnaz Atabak,

Shahnaz Atabak

Department of Nephrology, Shahid Modares Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran

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Su-Peng Loh,

Su-Peng Loh

Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia

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Leila Rahmani,

Leila Rahmani

Peritoneal Dialysis Ward, Shahid Modares Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran

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First published: 24 September 2012

https://doi.org/10.1111/j.1542-4758.2012.00754.x

Citations: 50

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Abstract

Inflammation and lipid abnormalities are two important risk factors for cardiovascular disease in hemodialysis (HD) patients. The present study was designed to investigate the effects of flaxseed consumption on systemic inflammation and serum lipid profile in HD patients with lipid abnormalities. This was an unblinded, randomized clinical trial. Thirty HD patients with dyslipidemia (triglyceride >200 mg/dL and/or high-density lipoprotein-cholesterol (HDL-C) <40 mg/dL) were randomly assigned to either a flaxseed or control group. Patients in the flaxseed group received 40 g/day ground flaxseed for 8 weeks, whereas patients in the control group received their usual diet, without any flaxseed. At baseline and at the end of week 8, 7 mL of blood was collected after a 12- to 14-hour fast and serum concentrations of triglyceride, total cholesterol, low-density lipoprotein-cholesterol (LDL-C), HDL-C, and C-reactive protein (CRP) were measured. Serum concentrations of triglyceride (P < 0.01), total cholesterol (P < 0.01), LDL-C (P < 0.01), and CRP (P < 0.05) decreased significantly in the flaxseed group at the end of week 8 compared with baseline, whereas serum HDL-C showed a significant increase (P < 0.01). These changes in the flaxseed group were significant in comparison with the control group. The study indicates that flaxseed consumption improves lipid abnormalities and reduces systemic inflammation in HD patients with lipid abnormalities.

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Volume17, Issue2

April 2013

Pages 275-281

Effects of flaxseed consumption on systemic inflammation and serum lipid profile in hemodialysis patients with lipid abnormalities

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Effects of flaxseed consumption on systemic inflammation and serum lipid profile in hemodialysis patients with lipid abnormalities

Abstract

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