Upfront FOLFOXIRI plus bevacizumab and reintroduction after progression versus mFOLFOX6 plus bevacizumab followed by FOLFIRI plus bevacizumab in the treatment of patients with metastatic colorectal cancer (TRIBE2): a multicentre, open-label, phase 3, randomised, controlled trial.
Lancet Oncol. 2020 Apr;21(4):497-507. doi: 10.1016/S1470-2045(19)30862-9. Epub 2020 Mar 9. Lancet Oncol. 2020. PMID: 32164906 Free article. Clinical Trial.
In the control group, patients received first-line mFOLFOX6 (85 mg/m(2) of intravenous oxaliplatin concurrently with 200 mg/m(2) of leucovorin over 120 min; 400 mg/m(2) intravenous bolus of fluorouracil; 2400 mg/m(2) continuous infusion of fluorouracil …
In the control group, patients received first-line mFOLFOX6 (85 mg/m(2) of intravenous oxaliplatin concurrently with 200 mg/m( …