Abstract
In the treatment of depressive disorders, conventional antidepressant therapy has been the mainstay of clinical management, along with well-established nonpharmacological interventions such as various kinds of psychotherapy. Over the last 2 decades, there has been considerable interest in the role of the gastrointestinal system and its microbiota on brain function, behavior, and mental health. Components of what is referred to as the microbiota-gut-brain axis have been uncovered, and further research has elicited functional capabilities such as “gut-brain modules.” Some studies have found associations with compositional alterations of gut microbiota in patients with depressive disorders and individuals experiencing symptoms of depression. Regarding the pathogenesis and neurobiology of depression itself, there appears to be a multifactorial contribution, in addition to the theories involving deficits in catecholaminergic and monoamine neurotransmission. Interestingly, there is evidence to suggest that antidepressants may play a role in modulating the gut microbiota, thereby possibly having an impact on the microbiota-gut-brain axis in this manner. The development of prebiotics, probiotics, and synbiotics has led to studies investigating not only their impact on the microbiota but also their therapeutic value in mental health. These psychobiotics have the potential to be used as therapeutic adjuncts in the treatment of depression. Regarding future directions, and in an attempt to further understand the role of the microbiota-gut-brain axis in depression, more studies such as those involving fecal microbiota transplantation will be required. In addition to recent findings, it is also suggested that more research will have to be undertaken to elicit whether specific strains of gut organisms are linked to depression. In terms of further investigation of the therapeutic potential of prebiotics, probiotics, and synbiotics as adjuncts to antidepressant treatment, we also expect there to be more research targeting specific microorganisms, as well as a strong focus on the effects of specific prebiotic fibers from an individualized (personalized) point of view.
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References
Abildgaard A, Elfving B, Hokland M, Wegener G, Lund S (2017) Probiotic treatment reduces depressive-like behaviour in rats independently of diet. Psychoneuroendocrinology 79:40–48. https://doi.org/10.1016/j.psyneuen.2017.02.014
Ait Chait Y, Mottawea W, Tompkins TA, Hammami R (2020) Unravelling the antimicrobial action of antidepressants on gut commensal microbes. Sci Rep 10(1). https://doi.org/10.1038/s41598-020-74934-9
Alcock J, Maley CC, Aktipis CA (2014) Is eating behavior manipulated by the gastrointestinal microbiota? Evolutionary pressures and potential mechanisms. Bioessays 36(10):940–949. https://doi.org/10.1002/bies.201400071
Alfaifi AA, Althemery AU (2022) Sociodemographic characteristics and health-related quality of life of individuals undergoing antidepressant therapy. Sci Rep 12(1). https://doi.org/10.1038/s41598-022-22164-6
Allen AP, Naughton M, Dowling J, Walsh A, Ismail F, Shorten G, Scott L, McLoughlin DM, Cryan JF, Dinan TG, Clarke G (2015) Serum BDNF as a peripheral biomarker of treatment-resistant depression and the rapid antidepressant response: a comparison of ketamine and ECT. J Affect Disord 186:306–311. https://doi.org/10.1016/j.jad.2015.06.033
Allen AP, Hutch W, Borre YE, Kennedy PJ, Temko A, Boylan G, Murphy E, Cryan JF, Dinan TG, Clarke G (2016) Bifidobacterium longum 1714 as a translational psychobiotic: modulation of stress, electrophysiology and neurocognition in healthy volunteers. Transl Psychiatry 6(11):e939. https://doi.org/10.1038/tp.2016.191
Alli SR, Gorbovskaya I, Liu JCW, Kolla NJ, Brown L, Müller DJ (2022) The gut microbiome in depression and potential benefit of prebiotics, probiotics and synbiotics: a systematic review of clinical trials and observational studies. Int J Mol Sci 23(9):4494. https://doi.org/10.3390/ijms23094494
Anderson JW, Baird P, Davis RH Jr, Ferreri S, Knudtson M, Koraym A, Waters V, Williams CL (2009) Health benefits of dietary fiber. Nutr Rev 67(4):188–205. https://doi.org/10.1111/j.1753-4887.2009.00189.x
Anglin R, Yuan Y, Moayyedi P, Tse F, Armstrong D, Leontiadis GI (2014) Risk of upper gastrointestinal bleeding with selective serotonin reuptake inhibitors with or without concurrent nonsteroidal anti-inflammatory use: a systematic review and meta-analysis. Am J Gastroenterol 109(6):811–819. https://doi.org/10.1038/ajg.2014.82
Arab A, Mehrabani S, Moradi S, Amani R (2019) The association between diet and mood: a systematic review of current literature. Psychiatry Res 271:428–437. https://doi.org/10.1016/j.psychres.2018.12.014
Bambury A, Sandhu K, Cryan JF, Dinan TG (2018) Finding the needle in the haystack: systematic identification of psychobiotics. Br J Pharmacol 175(24):4430–4438. https://doi.org/10.1111/bph.14127
Bastiaanssen TFS, Cowan CSM, Claesson MJ, Dinan TG, Cryan JF (2019) Making sense of … the microbiome in psychiatry. Int J Neuropsychopharmacol 22(1):37–52. https://doi.org/10.1093/ijnp/pyy067
Bayes J, Schloss J, Sibbritt D (2022) The effect of a Mediterranean diet on the symptoms of depression in young males (the “AMMEND” study): a randomized control trial. Am J Clin Nutr 116(2):nqac106. https://doi.org/10.1093/ajcn/nqac106
Belkacem N, Serafini N, Wheeler R, Derrien M, Boucinha L, Couesnon A, Cerf-Bensussan N, Gomperts Boneca I, Di Santo JP, Taha M-K, Bourdet-Sicard R (2017) Lactobacillus paracasei feeding improves immune control of influenza infection in mice. PloS One 12(9):e0184976. https://doi.org/10.1371/journal.pone.0184976
Bengoa AA, Dardis C, Garrote GL, Abraham AG (2021) Health-promoting properties of Lacticaseibacillus paracasei: a focus on kefir isolates and exopolysaccharide-producing strains. Foods 10(10):2239. https://doi.org/10.3390/foods10102239
Berding K, Vlckova K, Marx W, Schellekens H, Stanton C, Clarke G, Jacka F, Dinan TG, Cryan JF (2021) Diet and the microbiota–gut–brain axis: sowing the seeds of good mental health. Adv Nutr 12(4). https://doi.org/10.1093/advances/nmaa181
Berding K, Bastiaanssen TFS, Moloney GM, Boscaini S, Strain CR, Anesi A, Long-Smith C, Mattivi F, Stanton C, Clarke G, Dinan TG, Cryan JF (2023) Feed your microbes to deal with stress: a psychobiotic diet impacts microbial stability and perceived stress in a healthy adult population. Mol Psychiatry 28:601–610. https://doi.org/10.1038/s41380-022-01817-y
Bertelsen RJ, Jensen ET, Ringel-Kulka T (2016) Use of probiotics and prebiotics in infant feeding. Best Pract Res Clin Gastroenterol 30(1):39–48. https://doi.org/10.1016/j.bpg.2016.01.001
Bertollo AG, Grolli RE, Plissari ME, Gasparin VA, Quevedo J, Réus GZ, Bagatini MD, Ignácio ZM (2020) Stress and serum cortisol levels in major depressive disorder: a cross-sectional study. AIMS Neurosci 7(4):459–469. https://doi.org/10.3934/neuroscience.2020028
Björkholm C, Monteggia LM (2016) BDNF – a key transducer of antidepressant effects. Neuropharmacology 102:72–79. https://doi.org/10.1016/j.neuropharm.2015.10.034
Bordenstein SR, Theis KR (2015) Host biology in light of the microbiome: ten principles of holobionts and hologenomes. PLoS Biol 13(8):e1002226. https://doi.org/10.1371/journal.pbio.1002226
Bosch JA, Nieuwdorp M, Zwinderman AH, Deschasaux M, Radjabzadeh D, Kraaij R, Davids M, de Rooij SR, Lok A (2022) The gut microbiota and depressive symptoms across ethnic groups. Nat Commun 13(1):7129. https://doi.org/10.1038/s41467-022-34504-1
Bravo JA, Forsythe P, Chew MV, Escaravage E, Savignac HM, Dinan TG, Bienenstock J, Cryan JF (2011) Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. Proc Natl Acad Sci 108(38):16050–16055. https://doi.org/10.1073/pnas.1102999108
Burokas A, Arboleya S, Moloney RD, Peterson VL, Murphy K, Clarke G, Stanton C, Dinan TG, Cryan JF (2017) Targeting the microbiota-gut-brain axis: prebiotics have anxiolytic and antidepressant-like effects and reverse the impact of chronic stress in mice. Biol Psychiatry 82(7):472–487. https://doi.org/10.1016/j.biopsych.2016.12.031
Butler MI, Sandhu K, Cryan JF, Dinan TG (2019a) From isoniazid to psychobiotics: the gut microbiome as a new antidepressant target. Br J Hosp Med 80(3):139–145. https://doi.org/10.12968/hmed.2019.80.3.139
Butler MI, Mörkl S, Sandhu KV, Cryan JF, Dinan TG (2019b) The gut microbiome and mental health: what should we tell our patients?: Le microbiote intestinal et la Santé Mentale : que Devrions-Nous dire à nos Patients? Can J Psychiatry 64(11):706743719874168. https://doi.org/10.1177/0706743719874168
Butler MI, Bastiaanssen TFS, Long-Smith C, Morkl S, Berding K, Ritz NL, Strain C, Patangia D, Patel S, Stanton C, O’Mahony SM, Cryan JF, Clarke G, Dinan TG (2023) The gut microbiome in social anxiety disorder: evidence of altered composition and function. Transl Psychiatry 13(1):1–12. https://doi.org/10.1038/s41398-023-02325-5
Cammarota G, Ianiro G, Tilg H, Rajilić-Stojanović M, Kump P, Satokari R, Sokol H, Arkkila P, Pintus C, Hart A, Segal J, Aloi M, Masucci L, Molinaro A, Scaldaferri F, Gasbarrini G, Lopez-Sanroman A, Link A, de Groot P, de Vos WM (2017) European consensus conference on faecal microbiota transplantation in clinical practice. Gut 66(4):569–580. https://doi.org/10.1136/gutjnl-2016-313017
Carbia C, Bastiaanssen TFS, Iannone LF, García-Cabrerizo R, Boscaini S, Berding K, Strain CR, Clarke G, Stanton C, Dinan TG, Cryan JF (2023) The microbiome-gut-brain axis regulates social cognition & craving in young binge drinkers. EBioMedicine. https://doi.org/10.1016/j.ebiom.2023.104442
Carlson JL, Erickson JM, Lloyd BB, Slavin JL (2018) Health effects and sources of prebiotic dietary fiber. Curr Dev Nutr 2(3). https://doi.org/10.1093/cdn/nzy005
Carrozzino D, Patierno C, Fava GA, Guidi J (2020) The Hamilton rating scales for depression: a critical review of clinimetric properties of different versions. Psychother Psychosom 89(3):133–150. https://doi.org/10.1159/000506879
Ceban F, Rosenblat JD, Kratiuk K, Lee Y, Rodrigues NB, Gill H, Subramaniapillai M, Nasri F, Lui LMW, Lipsitz O, Kumar A, Lee JG, Chau EH, Cao B, Lin K, Ho RC, Mansur RB, Swainson J, McIntyre RS (2021) Prevention and management of common adverse effects of ketamine and esketamine in patients with mood disorders. CNS Drugs 35(9):925–934. https://doi.org/10.1007/s40263-021-00846-5
Celec P, Ostatníková D, Hodosy J (2015) On the effects of testosterone on brain behavioral functions. Front Neurosci 9. https://doi.org/10.3389/fnins.2015.00012
Chen L-M, Bao C-H, Wu Y, Liang S-H, Wang D, Wu L-Y, Huang Y, Liu H-R, Wu H-G (2021) Tryptophan-kynurenine metabolism: a link between the gut and brain for depression in inflammatory bowel disease. J Neuroinflammation 18:135. https://doi.org/10.1186/s12974-021-02175-2
Chu A, Wadhwa R (2022) Selective serotonin reuptake inhibitors. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK554406/
Cieślak A, Trottier J, Verreault M, Milkiewicz P, Vohl M-C, Barbier O (2018) N-3 polyunsaturated fatty acids stimulate bile acid detoxification in human cell models. Can J Gastroenterol Hepatol. https://doi.org/10.1155/2018/6031074
Cipriani A, Furukawa TA, Salanti G, Chaimani A, Atkinson LZ, Ogawa Y, Leucht S, Ruhe HG, Turner EH, Higgins JPT, Egger M, Takeshima N, Hayasaka Y, Imai H, Shinohara K, Tajika A, Ioannidis JPA, Geddes JR (2018) Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis. Lancet 391(10128):1357–1366. https://doi.org/10.1016/s0140-6736(17)32802-7
Clarke G, Quigley EMM, Cryan JF, Dinan TG (2009) Irritable bowel syndrome: towards biomarker identification. Trends Mol Med 15(10):478–489. https://doi.org/10.1016/j.molmed.2009.08.001
Clarke G, Stilling RM, Kennedy PJ, Stanton C, Cryan JF, Dinan TG (2014) Minireview: gut microbiota: the neglected endocrine organ. Mol Endocrinol 28(8):1221–1238. https://doi.org/10.1210/me.2014-1108
Clarke G, Sandhu KV, Griffin BT, Dinan TG, Cryan JF, Hyland NP (2019) Gut reactions: breaking down xenobiotic–microbiome interactions. Pharmacol Rev 71(2):198–224. https://doi.org/10.1124/pr.118.015768
Clauss M, Gérard P, Mosca A, Leclerc M (2021) Interplay between exercise and gut microbiome in the context of human health and performance. Front Nutr 8. https://doi.org/10.3389/fnut.2021.637010
Collins SL, Patterson AD (2020) The gut microbiome: an orchestrator of xenobiotic metabolism. Acta Pharm Sin B 10(1):19–32. https://doi.org/10.1016/j.apsb.2019.12.001
Colucci-D’Amato L, Speranza L, Volpicelli F (2020) Neurotrophic factor BDNF, physiological functions and therapeutic potential in depression, neurodegeneration and brain cancer. Int J Mol Sci 21(20). https://doi.org/10.3390/ijms21207777
Connolly KR, Thase ME (2016) Vortioxetine: a new treatment for major depressive disorder. Expert Opin Pharmacother 17(3):421–431. https://doi.org/10.1517/14656566.2016.1133588
Cruz-Pereira JS, Rea K, Nolan YM, O’Leary OF, Dinan TG, Cryan JF (2020) Depression’s unholy trinity: dysregulated stress, immunity, and the microbiome. Annu Rev Psychol 71(1):49–78. https://doi.org/10.1146/annurev-psych-122216-011613
Cryan JF, O’Riordan KJ, Cowan CSM, Sandhu KV, Bastiaanssen TFS, Boehme M, Codagnone MG, Cussotto S, Fulling C, Golubeva AV, Guzzetta KE, Jaggar M, Long-Smith CM, Lyte JM, Martin JA, Molinero-Perez A, Moloney G, Morelli E, Morillas E, O’Connor R (2019) The microbiota-gut-brain axis. Physiol Rev 99(4):1877–2013. https://doi.org/10.1152/physrev.00018.2018
Cussotto S, Strain CR, Fouhy F, Strain RG, Peterson VL, Clarke G, Stanton C, Dinan TG, Cryan JF (2018) Differential effects of psychotropic drugs on microbiome composition and gastrointestinal function. Psychopharmacology (Berl) 236(5):1671–1685. https://doi.org/10.1007/s00213-018-5006-5
Cussotto S, Clarke G, Dinan TG, Cryan JF (2019) Psychotropics and the microbiome: a chamber of secrets… . Psychopharmacology (Berl) 236(5):1411–1432. https://doi.org/10.1007/s00213-019-5185-8
Cussotto S, Clarke G, Dinan TG, Cryan JF (2021a) Psychotropic drugs and the microbiome. Modern Trends Psychiatry 32:113–133. https://doi.org/10.1159/000510423
Cussotto S, Walsh J, Golubeva AV, Zhdanov AV, Strain CR, Fouhy F, Stanton C, Dinan TG, Hyland NP, Clarke G, Cryan JF, Griffin BT (2021b) The gut microbiome influences the bioavailability of olanzapine in rats. EBioMedicine 66:103307. https://doi.org/10.1016/j.ebiom.2021.103307
D’Agostino A, English CD, Rey JA (2015) Vortioxetine (brintellix): a new serotonergic antidepressant. P T 40(1):36–40. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4296590/
Dalile B, Vervliet B, Bergonzelli G, Verbeke K, Van Oudenhove L (2020) Colon-delivered short-chain fatty acids attenuate the cortisol response to psychosocial stress in healthy men: a randomized, placebo-controlled trial. Neuropsychopharmacology 45(13):2257–2266. https://doi.org/10.1038/s41386-020-0732-x
Davani-Davari D, Negahdaripour M, Karimzadeh I, Seifan M, Mohkam M, Masoumi S, Berenjian A, Ghasemi Y (2019) Prebiotics: definition, types, sources, mechanisms, and clinical applications. Foods 8(3):92. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463098/
Davey P (ed) (2007) Medicine at a glance, 2nd edn. Blackwell Publishing, p 290
de Kloet ER, Joëls M, Holsboer F (2005) Stress and the brain: from adaptation to disease. Nat Rev Neurosci 6(6):463–475. https://doi.org/10.1038/nrn1683
de Vrese M, Schrezenmeir J (2008) Probiotics, prebiotics, and synbiotics. Food Biotechnol 111:1–66. https://doi.org/10.1007/10_2008_097
Dean OM, Data-Franco J, Giorlando F, Berk M (2012) Minocycline. CNS Drugs 26(5):391–401. https://doi.org/10.2165/11632000-000000000-00000
Dean OM, Kanchanatawan B, Ashton M, Mohebbi M, Ng CH, Maes M, Berk L, Sughondhabirom A, Tangwongchai S, Singh AB, McKenzie H, Smith DJ, Malhi GS, Dowling N, Berk M (2017) Adjunctive minocycline treatment for major depressive disorder: a proof of concept trial. Aust N Z J Psychiatry 51(8):829–840. https://doi.org/10.1177/0004867417709357
Diener C, Dai CL, Wilmanski T, Baloni P, Smith B, Rappaport N, Hood L, Magis AT, Gibbons SM (2022) Genome–microbiome interplay provides insight into the determinants of the human blood metabolome. Nat Metab 4(11):1560–1572. https://doi.org/10.1038/s42255-022-00670-1
Dinan TG, Cryan JF (2012) Regulation of the stress response by the gut microbiota: implications for psychoneuroendocrinology. Psychoneuroendocrinology 37(9):1369–1378. https://doi.org/10.1016/j.psyneuen.2012.03.007
Dinan TG, Stanton C, Cryan JF (2013) Psychobiotics: a novel class of psychotropic. Biol Psychiatry 74(10):720–726. https://doi.org/10.1016/j.biopsych.2013.05.001
Dinan TG, Butler MI, Cryan JF (2021) Psychobiotics: evolution of novel antidepressants. Modern Trends Psychiatry 32:134–143. https://doi.org/10.1159/000510424
Dong Z, Shen X, Hao Y, Li J, Xu H, Yin L, Kuang W (2022) Gut microbiome: a potential indicator for predicting treatment outcomes in major depressive disorder. Front Neurosci 16. https://doi.org/10.3389/fnins.2022.813075
Du Y, Gao X, Peng L, Jin-Fang G (2020) Crosstalk between the microbiota-gut-brain axis and depression. Heliyon 6(6):e04097. https://doi.org/10.1016/j.heliyon.2020.e04097
El-Salhy M, Mazzawi T, Hausken T, Hatlebakk JG (2022a) The fecal microbiota transplantation response differs between patients with severe and moderate irritable bowel symptoms. Scand J Gastroenterol 57(9):1036–1045. https://doi.org/10.1080/00365521.2022.2064725
El-Salhy M, Winkel R, Casen C, Hausken T, Gilja OH, Hatlebakk JG (2022b) Efficacy of fecal microbiota transplantation for patients with irritable bowel syndrome at three years after transplantation. Gastroenterology S0016-5085(22):006254. https://doi.org/10.1053/j.gastro.2022.06.020
Fayez R, Gupta V (2021) Imipramine. StatPearls Publishing. https://pubmed.ncbi.nlm.nih.gov/32491588/
Fernandez MA, Marette A (2017) Potential health benefits of combining yogurt and fruits based on their probiotic and prebiotic properties. Adv Nutr 8(1):155S164S. https://doi.org/10.3945/an.115.011114
Fontana A, Manchia M, Panebianco C, Paribello P, Arzedi C, Cossu E, Garzilli M, Montis MA, Mura A, Pisanu C, Congiu D, Copetti M, Pinna F, Carpiniello B, Squassina A, Pazienza V (2020) Exploring the role of gut microbiota in major depressive disorder and in treatment resistance to antidepressants. Biomedicine 8(9):311. https://doi.org/10.3390/biomedicines8090311
Frazer A (2001) Serotonergic and noradrenergic reuptake inhibitors: prediction of clinical effects from in vitro potencies. J Clin Psychiatry 62(Suppl 12):16–23. https://pubmed.ncbi.nlm.nih.gov/11430614/
Fülling C, Dinan TG, Cryan JF (2019) Gut microbe to brain Signaling: what happens in Vagus… . Neuron 101(6):998–1002. https://doi.org/10.1016/j.neuron.2019.02.008
Gareau MG, Wine E, Rodrigues DM, Cho JH, Whary MT, Philpott DJ, MacQueen G, Sherman PM (2010) Bacterial infection causes stress-induced memory dysfunction in mice. Gut 60(3):307–317. https://doi.org/10.1136/gut.2009.202515
Generoso JS, Giridharan VV, Lee J, Macedo D, Barichello T (2020) The role of the microbiota-gut-brain axis in neuropsychiatric disorders. Braz J Psychiatry 43(3):293–305. https://doi.org/10.1590/1516-4446-2020-0987
Gheorghe CE, Ritz NL, Martin JA, Wardill HR, Cryan JF, Clarke G (2021) Investigating causality with fecal microbiota transplantation in rodents: applications, recommendations and pitfalls. Gut Microbes 13(1). https://doi.org/10.1080/19490976.2021.1941711
Gheorghe CE, Cryan JF, Clarke G (2022) Debugging the gut-brain axis in depression. Cell Host Microbe 30(3):281–283. https://doi.org/10.1016/j.chom.2022.02.007
Ghorbani Z, Nazari S, Etesam F, Nourimajd S, Ahmadpanah M, Razeghi Jahromi S (2018) The effect of synbiotic as an adjuvant therapy to fluoxetine in moderate depression: a randomized multicenter trial. Arch Neurosci 5(2). https://doi.org/10.5812/archneurosci.60507
Green JE, McGuinness AJ, Berk M, Castle D, Athan E, Hair C et al (2023a) Safety and feasibility of faecal microbiota transplant for major depressive disorder: study protocol for a pilot randomised controlled trial. Pilot Feasibility Stud 9(1). https://doi.org/10.1186/s40814-023-01235-z
Green JE, Berk M, Mohebbi M, Loughman A, McGuinness AJ, Castle D, Chatterton ML, Perez J, Strandwitz P, Athan E, Hair C, Nierenberg AA, Cryan JF, Jacka F (2023b) Feasibility, acceptability, and safety of faecal microbiota transplantation in the treatment of major depressive disorder: a pilot randomized controlled trial. Can J Psychiatry 070674372211505. https://doi.org/10.1177/07067437221150508
Gupta A, Osadchiy V, Mayer EA (2020) Brain–gut–microbiome interactions in obesity and food addiction. Nat Rev Gastroenterol Hepatol 17(11):655–672. https://doi.org/10.1038/s41575-020-0341-5
Haas GS, Wang W, Saffar M, Mooney-Leber SM, Brummelte S (2020) Probiotic treatment (Bifidobacterium longum subsp. longum 35624™) affects stress responsivity in male rats after chronic corticosterone exposure. Behav Brain Res 393:112718. https://doi.org/10.1016/j.bbr.2020.112718
Hadinia N, Edalatian Dovom MR, Yavarmanesh M (2022) The effect of fermentation conditions (temperature, salt concentration, and pH) with lactobacillus strains for producing short chain fatty acids. LWT 165:113709. https://doi.org/10.1016/j.lwt.2022.113709
Haghighat N, Rajabi S, Mohammadshahi M (2021) Effect of synbiotic and probiotic supplementation on serum brain-derived neurotrophic factor level, depression and anxiety symptoms in hemodialysis patients: a randomized, double-blinded, clinical trial. Nutr Neurosci 24(6):490–499. https://doi.org/10.1080/1028415x.2019.1646975
Hansson GC (2019) Mucus and mucins in diseases of the intestinal and respiratory tracts. J Intern Med 285(5):479–490. https://doi.org/10.1111/joim.12910
Heijtz RD, Wang S, Anuar F, Qian Y, Bjorkholm B, Samuelsson A, Hibberd ML, Forssberg H, Pettersson S (2011) Normal gut microbiota modulates brain development and behavior. Proc Natl Acad Sci 108(7):3047–3052. https://doi.org/10.1073/pnas.1010529108
Holscher HD (2017) Dietary fiber and prebiotics and the gastrointestinal microbiota. Gut Microbes 8(2):172–184. https://doi.org/10.1080/19490976.2017.1290756
Hong J, Yoon D, Nam Y, Seo D, Kim J-H, Kim MS, Lee TY, Kim KS, Ko P-W, Lee H-W, Suk K, Kim SR (2020) Lipopolysaccharide administration for a mouse model of cerebellar ataxia with neuroinflammation. Sci Rep 10(1):13337. https://doi.org/10.1038/s41598-020-70390-7
Hooper LV, Littman DR, Macpherson AJ (2012) Interactions between the microbiota and the immune system. Science 336(6086):1268–1273. https://doi.org/10.1126/science.1223490
Huang R, Wang K, Hu J (2016) Effect of probiotics on depression: a systematic review and meta-analysis of randomized controlled trials. Nutrients 8(8):483. https://doi.org/10.3390/nu8080483
ISAPP (2022) Prebiotics. ISAPP. https://isappscience.org/for-scientists/resources/prebiotics/
Jacka FN, O’Neil A, Opie R, Itsiopoulos C, Cotton S, Mohebbi M, Castle D, Dash S, Mihalopoulos C, Chatterton ML, Brazionis L, Dean OM, Hodge AM, Berk M (2017) A randomised controlled trial of dietary improvement for adults with major depression (the “SMILES” trial). BMC Med 15(1):23. https://doi.org/10.1186/s12916-017-0791-y
Järbrink-Sehgal E, Andreasson A (2020) The gut microbiota and mental health in adults. Curr Opin Neurobiol 62:102–114. https://doi.org/10.1016/j.conb.2020.01.016
Jauhar S, Cowen PJ, Browning M (2023) Fifty years on: serotonin and depression. J Psychopharmacol 37(3):237–241. https://doi.org/10.1177/02698811231161813
Jiang H, Ling Z, Zhang Y, Mao H, Ma Z, Yin Y, Wang W, Tang W, Tan Z, Shi J, Li L, Ruan B (2015) Altered fecal microbiota composition in patients with major depressive disorder. Brain Behav Immun 48:186–194. https://doi.org/10.1016/j.bbi.2015.03.016
Karakan T, Ozkul C, Küpeli Akkol E, Bilici S, Sobarzo-Sánchez E, Capasso R (2021) Gut-brain-microbiota axis: antibiotics and functional gastrointestinal disorders. Nutrients 13(2):389. https://doi.org/10.3390/nu13020389
Kato-Kataoka A, Nishida K, Takada M, Suda K, Kawai M, Shimizu K, Kushiro A, Hoshi R, Watanabe O, Igarashi T, Miyazaki K, Kuwano Y, Rokutan K (2016) Fermented milk containing Lactobacillus casei strain Shirota prevents the onset of physical symptoms in medical students under academic examination stress. Benefic Microbes 7(2):153–156. https://doi.org/10.3920/bm2015.0100
Kazemi A, Noorbala AA, Azam K, Eskandari MH, Djafarian K (2019) Effect of probiotic and prebiotic vs placebo on psychological outcomes in patients with major depressive disorder: a randomized clinical trial. Clin Nutr 38(2):522–528. https://doi.org/10.1016/j.clnu.2018.04.010
Kelly JR, Kennedy PJ, Cryan JF, Dinan TG, Clarke G, Hyland NP (2015) Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders. Front Cell Neurosci 9:392. https://doi.org/10.3389/fncel.2015.00392
Kelly JR, Borre Y, O’Brien C, Patterson E, El Aidy S, Deane J, Kennedy PJ, Beers S, Scott K, Moloney G, Hoban AE, Scott L, Fitzgerald P, Ross P, Stanton C, Clarke G, Cryan JF, Dinan TG (2016) Transferring the blues: depression-associated gut microbiota induces neurobehavioural changes in the rat. J Psychiatr Res 82:109–118. https://doi.org/10.1016/j.jpsychires.2016.07.019
Kelly JR, Allen AP, Temko A, Hutch W, Kennedy PJ, Farid N, Murphy E, Boylan G, Bienenstock J, Cryan JF, Clarke G, Dinan TG (2017) Lost in translation? The potential psychobiotic Lactobacillus rhamnosus (JB-1) fails to modulate stress or cognitive performance in healthy male subjects. Brain Behav Immun 61:50–59. https://doi.org/10.1016/j.bbi.2016.11.018
Kennedy PJ, Cryan JF, Dinan TG, Clarke G (2017) Kynurenine pathway metabolism and the microbiota-gut-brain axis. Neuropharmacology 112:399–412. https://doi.org/10.1016/j.neuropharm.2016.07.002
Khalesi S, Bellissimo N, Vandelanotte C, Williams S, Stanley D, Irwin C (2019) A review of probiotic supplementation in healthy adults: helpful or hype? Eur J Clin Nutr 73(1):24–37. https://doi.org/10.1038/s41430-018-0135-9
Kim C-S, Cha L, Sim M, Jung S, Chun WY, Baik HW, Shin D-M (2020) Probiotic supplementation improves cognitive function and mood with changes in gut microbiota in community-dwelling elderly: a randomized, double-blind, placebo-controlled, multicenter trial. J Gerontol Ser A 76(1). https://doi.org/10.1093/gerona/glaa090
Klünemann M, Andrejev S, Blasche S, Mateus A, Phapale P, Devendran S, Vappiani J, Simon B, Scott TA, Kafkia E, Konstantinidis D, Zirngibl K, Mastrorilli E, Banzhaf M, Mackmull M-T, Hövelmann F, Nesme L, Brochado AR, Maier L, Bock T (2021) Bioaccumulation of therapeutic drugs by human gut bacteria. Nature 597(7877):533–538. https://doi.org/10.1038/s41586-021-03891-8
Kuyken W, Warren FC, Taylor RS, Whalley B, Crane C, Bondolfi G, Hayes R, Huijbers M, Ma H, Schweizer S, Segal Z, Speckens A, Teasdale JD, Van Heeringen K, Williams M, Byford S, Byng R, Dalgleish T (2016) Efficacy of mindfulness-based cognitive therapy in prevention of depressive relapse. JAMA Psychiatry 73(6):565. https://doi.org/10.1001/jamapsychiatry.2016.0076
Lancaster SM, Lee-McMullen B, Abbott CW, Quijada JV, Hornburg D, Park H, Perelman D, Peterson DJ, Tang M, Robinson A, Ahadi S, Contrepois K, Hung C-J, Ashland M, McLaughlin T, Boonyanit A, Horning A, Sonnenburg JL, Snyder MP (2022) Global, distinctive, and personal changes in molecular and microbial profiles by specific fibers in humans. Cell Host Microbe 30(6):848–862.e7. https://doi.org/10.1016/j.chom.2022.03.036
Lew L-C, Hor Y-Y, Yusoff NAA, Choi S-B, Yusoff MSB, Roslan NS, Ahmad A, Mohammad JAM, Abdullah MFIL, Zakaria N, Wahid N, Sun Z, Kwok L-Y, Zhang H, Liong M-T (2019) Probiotic Lactobacillus plantarum P8 alleviated stress and anxiety while enhancing memory and cognition in stressed adults: a randomised, double-blind, placebo-controlled study. Clin Nutr 38(5):2053–2064. https://doi.org/10.1016/j.clnu.2018.09.010
Li F, Tsien JZ (2009) Memory and the NMDA receptors. N Engl J Med 361(3):302–303. https://doi.org/10.1056/nejmcibr0902052
Li W, Guo J, Shen Y, Huang L, Leng B, Fan D, Shui L, Chen C (2020) Probiotics, prebiotics, and synbiotics for the treatment of dementia. Medicine 99(5):e18608. https://doi.org/10.1097/md.0000000000018608
Li D, Liu R, Wang M, Peng R, Fu S, Fu A, Le J, Yao Q, Yuan T, Chi H, Mu X, Sun T, Liu H, Yan P, Wang S, Cheng S, Deng Z, Liu Z, Wang G, Li Y (2022) 3β-hydroxysteroid dehydrogenase expressed by gut microbes degrades testosterone and is linked to depression in males. Cell Host Microbe 30(3):329–339.e5. https://doi.org/10.1016/j.chom.2022.01.001
Liang S, Wang T, Hu X, Luo J, Li W, Wu X, Duan Y, Jin F (2015) Administration of Lactobacillus helveticus NS8 improves behavioral, cognitive, and biochemical aberrations caused by chronic restraint stress. Neuroscience 310:561–577. https://doi.org/10.1016/j.neuroscience.2015.09.033
Liu C-F, Tseng K-C, Chiang S-S, Lee B-H, Hsu W-H, Pan T-M (2011) Immunomodulatory and antioxidant potential of Lactobacillus exopolysaccharides. J Sci Food Agric 91(12). https://doi.org/10.1002/jsfa.4456
Liu B, He Y, Wang M, Liu J, Ju Y, Zhang Y, Liu T, Li L, Li Q (2018) Efficacy of probiotics on anxiety-A meta-analysis of randomized controlled trials. Depress Anxiety 35(10):935–945. https://doi.org/10.1002/da.22811
Liu RT, Walsh RFL, Sheehan AE (2019) Prebiotics and probiotics for depression and anxiety: a systematic review and meta-analysis of controlled clinical trials. Neurosci Biobehav Rev 102:13–23. https://doi.org/10.1016/j.neubiorev.2019.03.023
Llopis M, Antolín M, Guarner F, Salas A, Malagelada J-R (2005) Mucosal colonisation with Lactobacillus casei mitigates barrier injury induced by exposure to trinitronbenzene sulphonic acid. Gut 54(7):955–959. https://doi.org/10.1136/gut.2004.056101
Long-Smith C, O’Riordan KJ, Clarke G, Stanton C, Dinan TG, Cryan JF (2020) Microbiota-gut-brain axis: new therapeutic opportunities. Annu Rev Pharmacol Toxicol 60(1):477–502. https://doi.org/10.1146/annurev-pharmtox-010919-023628
Luczynski P, McVey Neufeld K-A, Oriach CS, Clarke G, Dinan TG, Cryan JF (2016) Growing up in a bubble: using germ-free animals to assess the influence of the gut microbiota on brain and behavior. Int J Neuropsychopharmacol 19(8):pyw020. https://doi.org/10.1093/ijnp/pyw020
Lurie I, Yang Y-X, Haynes K, Mamtani R, Boursi B (2015) Antibiotic exposure and the risk for depression, anxiety, or psychosis: a nested case-control study. J Clin Psychiatry 76(11):1522–1528. https://doi.org/10.4088/JCP.15m09961
Lurie-Weinberger MN, Gophna U (2015) Archaea in and on the human body: health implications and future directions. PLoS Pathog 11(6):e1004833. https://doi.org/10.1371/journal.ppat.1004833
Mandal A, Sinha C, Kumar Jena A, Ghosh S, Samanta A (2010) An investigation on in vitro and in vivo antimicrobial properties of the antidepressant: amitriptyline hydrochloride. Braz J Microbiol 41(3):635–645. https://doi.org/10.1590/S1517-83822010000300014
Mannie ZN, Harmer CJ, Cowen PJ (2007) Increased waking salivary cortisol levels in young people at familial risk of depression. Am J Psychiatry 164(4):617–621. https://doi.org/10.1176/ajp.2007.164.4.617
Markowiak P, Śliżewska K (2017) Effects of probiotics, prebiotics, and synbiotics on human health. Nutrients 9(9):1021. https://doi.org/10.3390/nu9091021
Marx W, Scholey A, Firth J, D’Cunha NM, Lane M, Hockey M, Ashton MM, Cryan JF, O’Neil A, Naumovski N, Berk M, Dean OM, Jacka F (2020) Prebiotics, probiotics, fermented foods and cognitive outcomes: a meta-analysis of randomized controlled trials. Neurosci Biobehav Rev 118:472–484. https://doi.org/10.1016/j.neubiorev.2020.07.036
Marx W, Lane M, Hockey M, Aslam H, Berk M, Walder K, Borsini A, Firth J, Pariante CM, Berding K, Cryan JF, Clarke G, Craig JM, Su K-P, Mischoulon D, Gomez-Pinilla F, Foster JA, Cani PD, Thuret S, Staudacher HM (2021) Diet and depression: exploring the biological mechanisms of action. Mol Psychiatry 26:1–17. https://doi.org/10.1038/s41380-020-00925-x
Matijašić M, Meštrović T, Čipčić Paljetak H, Perić M, Barešić A, Verbanac D (2020) Gut microbiota beyond bacteria – Mycobiome, Virome, Archaeome, and eukaryotic parasites in IBD. Int J Mol Sci 21(8):2668. https://doi.org/10.3390/ijms21082668
Mayer SE, Lopez-Duran NL, Sen S, Abelson JL (2018) Chronic stress, hair cortisol and depression: a prospective and longitudinal study of medical internship. Psychoneuroendocrinology 92:57–65. https://doi.org/10.1016/j.psyneuen.2018.03.020
McGuinness AJ, Davis JA, Dawson SL, Loughman A, Collier F, O’Hely M, Simpson CA, Green J, Marx W, Hair C, Guest G, Mohebbi M, Berk M, Stupart D, Watters D, Jacka FN (2022) A systematic review of gut microbiota composition in observational studies of major depressive disorder, bipolar disorder and schizophrenia. Mol Psychiatry 27(4):1920–1935. https://doi.org/10.1038/s41380-022-01456-3
Messaoudi M, Violle N, Bisson J-F, Desor D, Javelot H, Rougeot C (2011) Beneficial psychological effects of a probiotic formulation (Lactobacillus helveticusR0052 and Bifidobacterium longumR0175) in healthy human volunteers. Gut Microbes 2(4):256–261. https://doi.org/10.4161/gmic.2.4.16108
Millischer V, Heinzl M, Faka A, Resl M, Trepci A, Klammer C, Egger M, Dieplinger B, Clodi M, Schwieler L (2021) Intravenous administration of LPS activates the kynurenine pathway in healthy male human subjects: a prospective placebo-controlled cross-over trial. J Neuroinflammation 18(1). https://doi.org/10.1186/s12974-021-02196-x
Misiak B, Łoniewski I, Marlicz W, Frydecka D, Szulc A, Rudzki L, Samochowiec J (2020) The HPA axis dysregulation in severe mental illness: can we shift the blame to gut microbiota? Prog Neuropsychopharmacol Biol Psychiatry 102:109951. https://doi.org/10.1016/j.pnpbp.2020.109951
Moloney RD, Johnson AC, O’Mahony SM, Dinan TG, Greenwood-Van Meerveld B, Cryan JF (2015) Stress and the microbiota-gut-brain axis in visceral pain: relevance to irritable bowel syndrome. CNS Neurosci Ther 22(2):102–117. https://doi.org/10.1111/cns.12490
Moloney GM, Long-Smith CM, Murphy A, Dorland D, Hojabri SF, Ramirez LO, Marin DC, Bastiaanssen TFS, Cusack A-M, Berding K, Fouhy F, Allen AP, Stanton C, Clarke G, Dinan TG, Cryan JF (2021) Improvements in sleep indices during exam stress due to consumption of a Bifidobacterium longum. Brain Behav Immun Health 10:100174. https://doi.org/10.1016/j.bbih.2020.100174
Morey JN, Boggero IA, Scott AB, Segerstrom SC (2015) Current directions in stress and human immune function. Curr Opin Psychol 5(1):13–17. https://doi.org/10.1016/j.copsyc.2015.03.007
Naughton M, Clarke G, O’Leary OF, Cryan JF, Dinan TG (2014) A review of ketamine in affective disorders: current evidence of clinical efficacy, limitations of use and pre-clinical evidence on proposed mechanisms of action. J Affect Disord 156:24–35. https://doi.org/10.1016/j.jad.2013.11.014
Nettis MA, Lombardo G, Hastings C, Zajkowska Z, Mariani N, Nikkheslat N, Worrell C, Enache D, McLaughlin A, Kose M, Sforzini L, Bogdanova A, Cleare A, Young AH, Pariante CM, Mondelli V (2021) Augmentation therapy with minocycline in treatment-resistant depression patients with low-grade peripheral inflammation: results from a double-blind randomised clinical trial. Neuropsychopharmacology 46(5):939–948. https://doi.org/10.1038/s41386-020-00948-6
NICE (2022) Recommendations | Depression in adults: treatment and management | Guidance https://www.nice.org.uk/guidance/ng222/chapter/Recommendations#choice-of-treatments
Nikolova VL, Smith MRB, Hall LJ, Cleare AJ, Stone JM, Young AH (2021) Perturbations in gut microbiota composition in psychiatric disorders. JAMA Psychiatry 78(12). https://doi.org/10.1001/jamapsychiatry.2021.2573
Nikolova VL, Cleare AJ, Young AH, Stone JM (2023) Acceptability, tolerability, and estimates of putative treatment effects of probiotics as adjunctive treatment in patients with depression. JAMA Psychiatry:e231817. https://doi.org/10.1001/jamapsychiatry.2023.1817
Nunez N, Réot L, Menu E (2021) Neonatal immune system ontogeny: the role of maternal microbiota and associated factors. How might the non-human primate model enlighten the path? Vaccines 9(6):584. https://doi.org/10.3390/vaccines9060584
O’Mahony SM, Clarke G, Borre YE, Dinan TG, Cryan JF (2015) Serotonin, tryptophan metabolism and the brain-gut-microbiome axis. Behav Brain Res 277:32–48. https://doi.org/10.1016/j.bbr.2014.07.027
O’Riordan KJ, Collins MK, Moloney GM, Knox EG, Aburto MR, Fülling C, Morley SJ, Clarke G, Schellekens H, Cryan JF (2022) Short chain fatty acids: microbial metabolites for gut-brain axis signalling. Mol Cell Endocrinol 546:111572. https://doi.org/10.1016/j.mce.2022.111572
Okubo R, Koga M, Katsumata N, Odamaki T, Matsuyama S, Oka M, Narita H, Hashimoto N, Kusumi I, Xiao J, Matsuoka YJ (2019) Effect of bifidobacterium breve A-1 on anxiety and depressive symptoms in schizophrenia: a proof-of-concept study. J Affect Disord 245:377–385. https://doi.org/10.1016/j.jad.2018.11.011
Oleskin AV, Shenderov BA (2019) Probiotics and psychobiotics: the role of microbial neurochemicals. Probiotics Antimicrob Proteins 11. https://doi.org/10.1007/s12602-019-09583-0
Pan W, Stone KP, Hsuchou H, Manda VK, Zhang Y, Kastin AJ (2011) Cytokine signaling modulates blood-brain barrier function. Curr Pharm Des 17(33):3729–3740. https://doi.org/10.2174/138161211798220918
Pan Z, Park C, Brietzke E, Zuckerman H, Rong C, Mansur RB, Fus D, Subramaniapillai M, Lee Y, McIntyre RS (2018) Cognitive impairment in major depressive disorder. CNS Spectr 24(1):22–29. https://doi.org/10.1017/s1092852918001207
Pandey KR, Naik SR, Vakil BV (2015) Probiotics, prebiotics and synbiotics – a review. J Food Sci Technol 52(12):7577–7587. https://doi.org/10.1007/s13197-015-1921-1
Parletta N, Zarnowiecki D, Cho J, Wilson A, Bogomolova S, Villani A, Itsiopoulos C, Niyonsenga T, Blunden S, Meyer B, Segal L, Baune BT, O’Dea K (2017) A Mediterranean-style dietary intervention supplemented with fish oil improves diet quality and mental health in people with depression: a randomized controlled trial (HELFIMED). Nutr Neurosci 22(7):474–487. https://doi.org/10.1080/1028415x.2017.1411320
Peirce JM, Alviña K (2019) The role of inflammation and the gut microbiome in depression and anxiety. J Neurosci Res 97(10):1223–1241. https://doi.org/10.1002/jnr.24476
Pham VT, Dold S, Rehman A, Bird JK, Steinert RE (2021) Vitamins, the gut microbiome and gastrointestinal health in humans. Nutr Res 95. https://doi.org/10.1016/j.nutres.2021.09.001
Phillips-Farfán B, Gómez-Chávez F, Medina-Torres EA, Vargas-Villavicencio JA, Carvajal-Aguilera K, Camacho L (2021) Microbiota signals during the neonatal period forge life-long immune responses. Int J Mol Sci 22(15):8162. https://doi.org/10.3390/ijms22158162
Pitharouli MC, Hagenaars SP, Glanville KP, Coleman JRI, Hotopf M, Lewis CM, Pariante CM (2021) Elevated C-reactive protein in patients with depression, independent of genetic, health, and psychosocial factors: results from the UK Biobank. Am J Psychiatry 178(6):522–529. https://doi.org/10.1176/appi.ajp.2020.20060947
Pluta R, Ułamek-Kozioł M, Januszewski S, Czuczwar SJ (2020) Gut microbiota and pro/prebiotics in Alzheimer’s disease. Aging 12(6):5539–5550. https://doi.org/10.18632/aging.102930
Poon T, Juana J, Noori D, Jeansen S, Pierucci-Lagha A, Musa-Veloso K (2020) Effects of a fermented dairy drink containing Lacticaseibacillus paracasei subsp. paracasei CNCM I-1518 (Lactobacillus casei CNCM I-1518) and the standard yogurt cultures on the incidence, duration, and severity of common infectious diseases: a systematic review and meta-analysis of randomized controlled trials. Nutrients 12(11):3443. https://doi.org/10.3390/nu12113443
Purton T, Staskova L, Lane MM, Dawson SL, West M, Firth J, Clarke G, Cryan JF, Berk M, O’Neil A, Dean O, Hadi A, Honan C, Marx W (2021) Prebiotic and probiotic supplementation and the tryptophan-kynurenine pathway: a systematic review and meta analysis. Neurosci Biobehav Rev 123:1–13. https://doi.org/10.1016/j.neubiorev.2020.12.026
Radjabzadeh D, Bosch JA, Uitterlinden AG, Zwinderman AH, Ikram MA, van Meurs JBJ, Luik AI, Nieuwdorp M, Lok A, van Duijn CM, Kraaij R, Amin N (2022) Gut microbiome-wide association study of depressive symptoms. Nat Commun 13(1):7128. https://doi.org/10.1038/s41467-022-34502-3
Raison CL, Capuron L, Miller AH (2006) Cytokines sing the blues: inflammation and the pathogenesis of depression. Trends Immunol 27(1):24–31. https://doi.org/10.1016/j.it.2005.11.006
Ramamoorthy S, Cidlowski JA (2016) Corticosteroids: mechanisms of action in health and disease. Rheum Dis Clin North Am 42(1):15–31. https://doi.org/10.1016/j.rdc.2015.08.002
Rao AV, Bested AC, Beaulne TM, Katzman MA, Iorio C, Berardi JM, Logan AC (2009) A randomized, double-blind, placebo-controlled pilot study of a probiotic in emotional symptoms of chronic fatigue syndrome. Gut Pathogens 1(1):6. https://doi.org/10.1186/1757-4749-1-6
Reigstad CS, Salmonson CE, Rainey JF, Szurszewski JH, Linden DR, Sonnenburg JL, Farrugia G, Kashyap PC (2015) Gut microbes promote colonic serotonin production through an effect of short-chain fatty acids on enterochromaffin cells. FASEB J 29(4):1395–1403. https://doi.org/10.1096/fj.14-259598
Rezaei Asl Z, Sepehri G, Salami M (2019) Probiotic treatment improves the impaired spatial cognitive performance and restores synaptic plasticity in an animal model of Alzheimer’s disease. Behav Brain Res 376:112183. https://doi.org/10.1016/j.bbr.2019.112183
Richardson L, Adams S (2018) Cognitive deficits in patients with depression. J Nurse Pract 14(6):437–443.e3. https://doi.org/10.1016/j.nurpra.2018.03.006
Royal College of Psychiatrists (2017) Statement on ketamine to treat depression. https://www.rcpsych.ac.uk/docs/default-source/about-us/who-we-are/ectcommittee-ketamine-to-treat-depression-statement-feb17.pdf?sfvrsn=db4e7a95_2
Royal College of Psychiatrists (2019) Physical illness. RC Psychiatry Royal College of Psychiatrists. https://www.rcpsych.ac.uk/mental-health/problems-disorders/physical-illness
Rudzki L, Ostrowska L, Pawlak D, Małus A, Pawlak K, Waszkiewicz N, Szulc A (2019) Probiotic lactobacillus plantarum 299v decreases kynurenine concentration and improves cognitive functions in patients with major depression: a double-blind, randomized, placebo controlled study. Psychoneuroendocrinology 100:213–222. https://doi.org/10.1016/j.psyneuen.2018.10.010
Ruhé HG, Mason NS, Schene AH (2007) Mood is indirectly related to serotonin, norepinephrine and dopamine levels in humans: a meta-analysis of monoamine depletion studies. Mol Psychiatry 12(4):331–359. https://doi.org/10.1038/sj.mp.4001949
Salli K, Lehtinen MJ, Tiihonen K, Ouwehand AC (2019) Xylitol’s health benefits beyond dental health: a comprehensive review. Nutrients 11(8):1813. https://doi.org/10.3390/nu11081813
Sarkar A, Lehto SM, Harty S, Dinan TG, Cryan JF, Burnet PWJ (2016) Psychobiotics and the manipulation of bacteria–gut–brain signals. Trends Neurosci 39(11):763–781. https://doi.org/10.1016/j.tins.2016.09.002
Schildkraut JJ (1965) The catecholamine hypothesis of affective disorders: a review of supporting evidence. Am J Psychiatry 122(5):509–522. https://doi.org/10.1176/ajp.122.5.509
Schmidt K, Cowen PJ, Harmer CJ, Tzortzis G, Errington S, Burnet PWJ (2015) Prebiotic intake reduces the waking cortisol response and alters emotional bias in healthy volunteers. Psychopharmacology (Berl) 232(10):1793–1801. https://doi.org/10.1007/s00213-014-3810-0
Semple D, Smyth R (2009) Oxford handbook of psychiatry, Oxford University Press, pp 266, 788, 790
Sheffler Z, Patel P, Abdijadid S (2022) Antidepressants. StatPearls Publishing
Sidhu G, Marwaha R (2023) Phenelzine. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK554508/
Silk DBA, Davis A, Vulevic J, Tzortzis G, Gibson GR (2009) Clinical trial: the effects of a trans-galactooligosaccharide prebiotic on faecal microbiota and symptoms in irritable bowel syndrome. Aliment Pharmacol Ther 29(5):508–518. https://doi.org/10.1111/j.1365-2036.2008.03911.x
Silva YP, Bernardi A, Frozza RL (2020) The role of short-chain fatty acids from gut microbiota in gut-brain communication. Front Endocrinol 11(25). https://doi.org/10.3389/fendo.2020.00025
Simpson CA, Diaz-Arteche C, Eliby D, Schwartz OS, Simmons JG, Cowan CSM (2021) The gut microbiota in anxiety and depression – a systematic review. Clin Psychol Rev 83:101943. https://doi.org/10.1016/j.cpr.2020.101943
Siniscalco D, Schultz S, Brigida A, Antonucci N (2018) Inflammation and neuro-immune dysregulations in autism spectrum disorders. Pharmaceuticals 11(2):56. https://doi.org/10.3390/ph11020056
Siopi E, Chevalier G, Katsimpardi L, Saha S, Bigot M, Moigneu C, Eberl G, Lledo P-M (2020) Changes in gut microbiota by chronic stress impair the efficacy of fluoxetine. Cell Rep 30(11):3682–3690.e6. https://doi.org/10.1016/j.celrep.2020.02.099
Sirisinha S (2016) The potential impact of gut on your health: current status and future challenges. Asian Pac J Allergy Immunol 34(4):249–264. https://doi.org/10.12932/ap0803
Sivcev S, Slavikova B, Rupert M, Ivetic M, Nekardova M, Kudova E, Zemkova H (2019) Synthetic testosterone derivatives modulate rat P2X2 and P2X4 receptor channel gating. J Neurochem 150(1):28–43. https://doi.org/10.1111/jnc.14718
Slavin J (2013) Fiber and prebiotics: mechanisms and health benefits. Nutrients 5(4):1417–1435. https://doi.org/10.3390/nu5041417
Smith A, Sutherland D, Hewlett P (2015) An investigation of the acute effects of oligofructose-enriched inulin on subjective wellbeing, mood and cognitive performance. Nutrients 7(11):8887–8896. https://doi.org/10.3390/nu7115441
Smith KS, Greene MW, Babu JR, Frugé AD (2021) Psychobiotics as treatment for anxiety, depression, and related symptoms: a systematic review. Nutr Neurosci 24(12):963–977. https://doi.org/10.1080/1028415x.2019.1701220
Song W, Hu P, Guo S, Hu J, Song C, Wang T, Gao Z, Yue T (2021) Oxidative stress and endoplasmic reticulum stress contribute to L. paracasei subsp. paracasei M5L exopolysaccharide-induced apoptosis in HT-29 cells. Food Sci Nutr 9(3):1676–1687. https://doi.org/10.1002/fsn3.2142
Spichak S, Bastiaanssen TFS, Berding K, Vlckova K, Clarke G, Dinan TG, Cryan JF (2021) Mining microbes for mental health: determining the role of microbial metabolic pathways in human brain health and disease. Neurosci Biobehav Rev 125. https://doi.org/10.1016/j.neubiorev.2021.02.044
Steenbergen L, Sellaro R, van Hemert S, Bosch JA, Colzato LS (2015) A randomized controlled trial to test the effect of multispecies probiotics on cognitive reactivity to sad mood. Brain Behav Immun 48:258–264. https://doi.org/10.1016/j.bbi.2015.04.003
Sub Laban T, Saadabadi A (2022) Monoamine oxidase inhibitors (MAOI). StatPearls Publishing
Sugahara H, Odamaki T, Fukuda S, Kato T, Xiao J, Abe F, Kikuchi J, Ohno H (2015) Probiotic bifidobacterium longum alters gut luminal metabolism through modification of the gut microbial community. Sci Rep 5. https://doi.org/10.1038/srep13548
Suganya K, Koo B-S (2020) Gut–brain axis: role of gut microbiota on neurological disorders and how probiotics/prebiotics beneficially modulate microbial and immune pathways to improve brain functions. Int J Mol Sci 21(20):7551. https://doi.org/10.3390/ijms21207551
Sun C-Y, Zheng Z-L, Chen C-W, Lu B-W, Liu D (2022) Targeting gut microbiota with natural polysaccharides: effective interventions against high-fat diet-induced metabolic diseases. Front Microbiol 13. https://doi.org/10.3389/fmicb.2022.859206
Swanson KS, Gibson GR, Hutkins R, Reimer RA, Reid G, Verbeke K, Scott KP, Holscher HD, Azad MB, Delzenne NM, Sanders ME (2020) The international scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of synbiotics. Nat Rev Gastroenterol Hepatol 17(11):687–701. https://doi.org/10.1038/s41575-020-0344-2
Tang WHW, Bäckhed F, Landmesser U, Hazen SL (2019) Intestinal microbiota in cardiovascular health and disease. J Am Coll Cardiol 73(16):2089–2105. https://doi.org/10.1016/j.jacc.2019.03.024
Taylor DM, Paton C, Kapur S (2012) The Maudsley prescribing guidelines in psychiatry. Wiley, pp 202–239
Thau L, Gandhi J, Sharma S (2022) Physiology, cortisol. StatPearls Publishing. https://pubmed.ncbi.nlm.nih.gov/30855827/
Tian P, O’Riordan KJ, Lee Y, Wang G, Zhao J, Zhang H, Cryan JF, Chen W (2020) Towards a psychobiotic therapy for depression: bifidobacterium breve CCFM1025 reverses chronic stress-induced depressive symptoms and gut microbial abnormalities in mice. Neurobiol Stress 12:100216. https://doi.org/10.1016/j.ynstr.2020.100216
Tian P, Bastiaanssen TFS, Song L, Jiang B, Zhang X, Zhao J, Zhang H, Chen W, Cryan JF, Wang G (2021) Unraveling the microbial mechanisms underlying the psychobiotic potential of a bifidobacterium breve strain. Mol Nutr Food Res 65(8):e2000704. https://doi.org/10.1002/mnfr.202000704
Tian P, Chen Y, Zhu H, Wang L, Qian X, Zou R, Zhao J, Zhang H, Qian L, Wang Q, Wang G, Chen W (2022) Bifidobacterium breve CCFM1025 attenuates major depression disorder via regulating gut microbiome and tryptophan metabolism: a randomized clinical trial. Brain Behav Immun 100:233–241. https://doi.org/10.1016/j.bbi.2021.11.023
Tiller J (2013) Depression and anxiety. Med J Aust 199(6):S28–S31. https://doi.org/10.5694/mja12.10628
Tsukuda N, Yahagi K, Hara T, Watanabe Y, Matsumoto H, Mori H, Higashi K, Tsuji H, Matsumoto S, Kurokawa K, Matsuki T (2021) Key bacterial taxa and metabolic pathways affecting gut short-chain fatty acid profiles in early life. ISME J 15(9):2574–2590. https://doi.org/10.1038/s41396-021-00937-7
U.S. National Library of Medicine (2023) Home – ClinicalTrials.gov. NIH U.S. National Library of Medicine. https://clinicaltrials.gov/
Valles-Colomer M, Falony G, Darzi Y, Tigchelaar EF, Wang J, Tito RY, Schiweck C, Kurilshikov A, Joossens M, Wijmenga C, Claes S, Van Oudenhove L, Zhernakova A, Vieira-Silva S, Raes J (2019) The neuroactive potential of the human gut microbiota in quality of life and depression. Nat Microbiol 4(4):623–632. https://doi.org/10.1038/s41564-018-0337-x
Valles-Colomer M, Blanco-Míguez A, Manghi P, Asnicar F, Dubois L, Golzato D, Armanini F, Cumbo F, Huang KD, Manara S, Masetti G, Pinto F, Piperni E, Punčochář M, Ricci L, Zolfo M, Farrant O, Goncalves A, Selma-Royo M, Binetti AG (2023) The person-to-person transmission landscape of the gut and oral microbiomes. Nature 614:125–135. https://doi.org/10.1038/s41586-022-05620-1
van de Wouw M, Boehme M, Lyte JM, Wiley N, Strain C, O’Sullivan O, Clarke G, Stanton C, Dinan TG, Cryan JF (2018) Short-chain fatty acids: microbial metabolites that alleviate stress-induced brain-gut axis alterations. J Physiol 596(20):4923–4944. https://doi.org/10.1113/jp276431
Vidot H, Cvejic E, Finegan LJ, Shores EA, Bowen DG, Strasser SI, McCaughan GW, Carey S, Allman-Farinelli M, Shackel NA (2019) Supplementation with synbiotics and/or branched chain amino acids in hepatic encephalopathy: a pilot randomised placebo-controlled clinical study. Nutrients 11(8):1810. https://doi.org/10.3390/nu11081810
Wallace CJK, Milev R (2017) The effects of probiotics on depressive symptoms in humans: a systematic review. Ann Gen Psychiatry 16(1). https://doi.org/10.1186/s12991-017-0138-2
Wang H, Braun C, Murphy EF, Enck P (2019a) Bifidobacterium longum 1714™ strain modulates brain activity of healthy volunteers during social stress. Am J Gastroenterol 114(7):1152–1162. https://doi.org/10.14309/ajg.0000000000000203
Wang J-W, Kuo C-H, Kuo F-C, Wang Y-K, Hsu W-H, Yu F-J, Hu H-M, Hsu P-I, Wang J-Y, Wu D-C (2019b) Fecal microbiota transplantation: review and update. J Formos Med Assoc 118(1):S23–S31. https://doi.org/10.1016/j.jfma.2018.08.011
Wang Z, Liu S, Xu X, Xiao Y, Yang M, Zhao X, Jin C, Hu F, Yang S, Tang B, Song C, Wang T (2022) Gut microbiota associated with effectiveness and responsiveness to mindfulness-based cognitive therapy in improving trait anxiety. Front Cell Infect Microbiol 12:719829. https://doi.org/10.3389/fcimb.2022.719829
Whisner CM, Castillo LF (2017) Prebiotics, bone and mineral metabolism. Calcif Tissue Int 102(4):443–479. https://doi.org/10.1007/s00223-017-0339-3
Wiertsema SP, van Bergenhenegouwen J, Garssen J, Knippels LMJ (2021) The interplay between the gut microbiome and the immune system in the context of infectious diseases throughout life and the role of nutrition in optimizing treatment strategies. Nutrients 13(3):886. https://doi.org/10.3390/nu13030886
Williams S, Chen L, Savignac HM, Tzortzis G, Anthony DC, Burnet PW (2016) Neonatal prebiotic (BGOS) supplementation increases the levels of synaptophysin, GluN2A-subunits and BDNF proteins in the adult rat hippocampus. Synapse 70(3):121–124. https://doi.org/10.1002/syn.21880
Wilson M, Tripp J (2023) Clomipramine. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK541006/#article-42905.s5
Wittenberg GM, Stylianou A, Zhang Y, Sun Y, Gupta A, Jagannatha PS, Wang D, Hsu B, Curran ME, Khan S, Chen G, Bullmore ET, Drevets WC (2019) Effects of immunomodulatory drugs on depressive symptoms: a mega-analysis of randomized, placebo-controlled clinical trials in inflammatory disorders. Mol Psychiatry 25(6). https://doi.org/10.1038/s41380-019-0471-8
Woo YS, Rosenblat JD, Kakar R, Bahk W-M, McIntyre RS (2016) Cognitive deficits as a mediator of poor occupational function in remitted major depressive disorder patients. Clin Psychopharmacol Neurosci 14(1):1–16. https://doi.org/10.9758/cpn.2016.14.1.1
Wu W-L, Adame MD, Liou C-W, Barlow JT, Lai T-T, Sharon G, Schretter CE, Needham BD, Wang MI, Tang W, Ousey J, Lin Y-Y, Yao T-H, Abdel-Haq R, Beadle K, Gradinaru V, Ismagilov RF, Mazmanian SK (2021a) Microbiota regulate social behaviour via stress response neurons in the brain. Nature 595(7867):409–414. https://doi.org/10.1038/s41586-021-03669-y
Wu G, Zhao N, Zhang C, Lam YY, Zhao L (2021b) Guild-based analysis for understanding gut microbiome in human health and diseases. Genome Med 13(1). https://doi.org/10.1186/s13073-021-00840-y
Ye X, Wang D, Zhu H, Wang D, Li J, Tang Y, Wu J (2021) Gut microbiota changes in patients with major depressive disorder treated with vortioxetine. Front Psych 12. https://doi.org/10.3389/fpsyt.2021.641491
Zanos P, Gould TD (2018) Mechanisms of ketamine action as an antidepressant. Mol Psychiatry 23(4):801–811. https://doi.org/10.1038/mp.2017.255
Zhang W, Qu W, Wang H, Yan H (2021) Antidepressants fluoxetine and amitriptyline induce alterations in intestinal microbiota and gut microbiome function in rats exposed to chronic unpredictable mild stress. Transl Psychiatry 11(1). https://doi.org/10.1038/s41398-021-01254-5
Zheng P, Zeng B, Zhou C, Liu M, Fang Z, Xu X, Zeng L, Chen J, Fan S, Du X, Zhang X, Yang D, Yang Y, Meng H, Li W, Melgiri ND, Licinio J, Wei H, Xie P (2016) Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host’s metabolism. Mol Psychiatry 21(6):786–796. https://doi.org/10.1038/mp.2016.44
Zimmermann M, Zimmermann-Kogadeeva M, Wegmann R, Goodman AL (2019) Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature 570(7762):462–467. https://doi.org/10.1038/s41586-019-1291-3
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The authors would like to thank Dr. Kenneth O’Riordan for his assistance in contributing to this chapter.
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Lachmansingh, D.A., Lavelle, A., Cryan, J.F., Clarke, G. (2023). Microbiota-Gut-Brain Axis and Antidepressant Treatment. In: Current Topics in Behavioral Neurosciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7854_2023_449
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