Patient Perceptions of Microbiome-Based Therapies as Novel Treatments for Mood Disorders: A Mixed Methods Study: Perceptions des patients sur les thérapies basées sur le microbiome pour les troubles de l’humeur : une étude à méthodes mixtes
Abstract
Abstract
Objective
Methods
Results
Conclusion
Résumé
Objectif
Méthodes
Résultats
Conclusion
Introduction
Methods
Study Design
Recruitment
Data Collection
Interventions
Data Analysis
Statistical Analysis
Results
Qualitative Evaluation
Gender | Major depressive disorder | Bipolar disorder |
---|---|---|
Quantitative study participants | ||
Female | 16 (37.2%) | 16 (37.2%) |
Male | 4 (9.3%) | 6 (14.0%) |
Other | 0 (0.0%) | 1 (2.3%) |
Total | 20 (46.5%) | 23 (53.5%) |
Qualitative study participants | ||
Female | 7 (35.0%) | 9 (45.0%) |
Male | 0 (0.0%) | 4 (20.0%) |
Other | 0 (0.0%) | 0 (0.0%) |
Total | 7 (35.0%) | 13 (65.0%) |
Theme | Subtheme | Illustrative quote |
---|---|---|
Theme 1: Lack of resources and knowledge on MBT | ||
Limited availability of essential resources | Living with bipolar disorder is a constant struggle, but I've heard whispers about the potential of microbiome-based therapies […] It leaves us feeling lost and without the essential knowledge we need to improve our mental health. (Participant 11) | |
Inadequate familiarity with MBT and its potential advantages | The limited awareness of these other treatments hinders our ability to make informed decisions about our ever-so-changing health. (Participant 12) | |
Theme 2: Emotional impact, concerns and uncertainty surrounding MBT | ||
[…] triggers a range of emotions within me, including anxiety. I worry about the potential risks, the impact on my overall health, and whether it will truly help alleviate my condition […] I’ve just jumped from medication to medication which have skipped my symptoms and made it worse, so it is traumatic for me to try new medication. (Participant 4) | ||
Theme 3: Practical challenges of MBT | ||
Financial ramifications and anxieties pertaining to the exorbitant cost of MBT | The cost of [MBT] often leads to major financial stress. I mean the potential for improved health comes with a hefty price tag, leaving us to grapple with ‘how do we go ahead and pursue these treatments? (Participant 13) | |
Theme 4: Practical challenges of current psychotherapy medications | Disruption to daily routines, livelihoods, and established schedules | I've been thinking about maybe tweaking my diet. Anything to help me. It's like, these mood swings and daily chaos are draining. (Participant 11) |
Living with depression, I'm constantly searching for new approaches to manage my symptoms. The limited availability of essential resources for microbiome-based therapies feels like a roadblock, preventing us from exploring potential treatments that could offer hope and a renewed sense of well-being. (Participant 9)
I wish more doctors and healthcare professionals were familiar with the potential advantages of these treatments. It's disheartening to encounter skepticism or lack of awareness from others, which prevents from accessing innovative approaches to treatment. (Participant 9)
To be honest, I'd like to hear more from you about the fecal transplantation, because I don't honestly know how that works and sort of what's involved, what's the procedure, and you know, how do you evaluate effectiveness and so on. (Participant 14)
I wish there was less stigma surrounding MBT treatments […] I talk to my family about it just to feel judged or invalidated for considering innovative approaches that could potentially improve my health and well-being. (Participant 14)
Choosing [MBT] for my mood [disorder] is tricky. Switching from my current meds, I stress about potential rough patches, even if the new approach works. The fear of any side effects with new treatments adds to the hesitation. It's a tough call. (Participant 3)
If I could find something a little bit better that isn't medication, whether it be food change or something else, I would try it. (Participant 7)
If [the MBT] are beneficial and they're proven safe and effective I don't have a problem trying things out that could eliminate a pill to make it more natural from what I eat, as opposed to putting it into my system. (Participant 15)
The cost [of probiotics] would be the biggest factor for me, definitely! It can feel overwhelming. The fear of accumulating medical expenses and the strain it puts on finances adds a layer of stress. So, I wouldn’t be able to continue the probiotics because I couldn’t afford it. (Participant 12)
You know, living with this [mood disorder] it messes up everything—work, relationships, just daily life. It's this ongoing struggle with mood swings, fatigue, and brain fog. But hey, thinking about trying something new, like a different diet, feels like grabbing a bit of control back. It's not a cure-all, but it's a little something to maybe make life's craziness a bit more manageable. (Participant 17)
Quantitative Results
Willingness to try MBT | Major depressive disorder | Bipolar disorder | Total |
---|---|---|---|
Yes | 17 (39.5%) | 14 (32.6%) | 31 (72.1%) |
No | 0 (0.0%) | 1 (2.3%) | 1 (2.2%) |
Unsure | 3 (7.0%) | 8 (18.6%) | 11 (25.6%) |
MBT | Major depressive disorder (n = 20) | Bipolar disorder (n = 23) | ||||||
---|---|---|---|---|---|---|---|---|
Ranking | 1 | 2 | 3 | 4 | 1 | 2 | 3 | 4 |
Probiotics | 5 (25.0%) | 5 (25.0%) | 5 (25.0%) | 5 (25.0%) | 11 (47.8%) | 6 (26.1%) | 3 (13.0%) | 3 (13.0%) |
Prebiotics | 2 (10.0%) | 7 (35.0%) | 11 (55.0%) | 0 (0.0%) | 0 (0.0%) | 11 (47.8%) | 10 (43.5%) | 2 (8.7%) |
Dietary change | 5 (25.0%) | 7 (35.0%) | 4 (20.0%) | 4 (20.0%) | 6 (26.1%) | 4 (17.4%) | 8 (34.8%) | 5 (21.7%) |
FMT | 8 (40.0%) | 1 (5.0%) | 0 (0.0%) | 11 (55.0%) | 6 (26.1%) | 2 (8.7%) | 2 (8.7%) | 13 (56.5%) |
Discussion
Which Factors Affect an Individual's Decision to Try MBT?
Limitations
Conclusion
Acknowledgements
Declaration of Conflicting Interests
Funding
ORCID iD
References
Supplementary Material
Please find the following supplemental material available below.
For Open Access articles published under a Creative Commons License, all supplemental material carries the same license as the article it is associated with.
For non-Open Access articles published, all supplemental material carries a non-exclusive license, and permission requests for re-use of supplemental material or any part of supplemental material shall be sent directly to the copyright owner as specified in the copyright notice associated with the article.
Cite article
Cite article
Cite article
Download to reference manager
If you have citation software installed, you can download article citation data to the citation manager of your choice
Information, rights and permissions
Information
Published In
Keywords
Mots-clés
Authors
Metrics and citations
Metrics
Journals metrics
This article was published in The Canadian Journal of Psychiatry.
VIEW ALL JOURNAL METRICSArticle usage*
Total views and downloads: 617
*Article usage tracking started in December 2016
Articles citing this one
Receive email alerts when this article is cited
Web of Science: 0
Crossref: 0
There are no citing articles to show.
Figures and tables
Figures & Media
Tables
View Options
View options
PDF/ePub
View PDF/ePubGet access
Access options
If you have access to journal content via a personal subscription, university, library, employer or society, select from the options below:
loading institutional access options
CPA members can access this journal content using society membership credentials.
CPA members can access this journal content using society membership credentials.
Alternatively, view purchase options below:
Purchase 24 hour online access to view and download content.
Access journal content via a DeepDyve subscription or find out more about this option.