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Cyanidin-3-O-glucoside Protects Lens Epithelial Cells against High Glucose-Induced Apoptosis and Prevents Cataract Formation via Suppressing NF-κB Activation and Cox-2 Expression
- Xi-Ling Song
Xi-Ling SongDepartment of Public Health and Preventive Medicine, Jinan University, Guangzhou 510632, ChinaMore by Xi-Ling Song
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- Mei-Jun Li
Mei-Jun LiDepartment of Ophthalmology, the First Affiliated Hospital, Jinan University, Guangzhou 510632, ChinaMore by Mei-Jun Li
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- Qun Liu
Qun LiuDepartment of Histology and Embryology, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou 511436, ChinaMore by Qun Liu
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- Zi-Xuan Hu
Zi-Xuan HuDepartment of Public Health and Preventive Medicine, Jinan University, Guangzhou 510632, ChinaWest Campus, University of Chinese Acadamy of Sciences Shenzhen Hospital, Shenzhen 518107, ChinaMore by Zi-Xuan Hu
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- Zhi-Yi Xu
Zhi-Yi XuDepartment of Ophthalmology, the First Affiliated Hospital, Jinan University, Guangzhou 510632, ChinaMore by Zhi-Yi Xu
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- Jia-Hui Li
Jia-Hui LiDepartment of Public Health and Preventive Medicine, Jinan University, Guangzhou 510632, ChinaMore by Jia-Hui Li
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- Wen-Lin Zheng
Wen-Lin ZhengDepartment of Public Health and Preventive Medicine, Jinan University, Guangzhou 510632, ChinaMore by Wen-Lin Zheng
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- Xiao-Mei Huang
Xiao-Mei HuangDepartment of Ophthalmology, the First Affiliated Hospital, Jinan University, Guangzhou 510632, ChinaMore by Xiao-Mei Huang
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- Fan Xiao
Fan XiaoDepartment of Public Health and Preventive Medicine, Jinan University, Guangzhou 510632, ChinaMore by Fan Xiao
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- Yu-Hong Cui
Yu-Hong CuiDepartment of Histology and Embryology, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou 511436, ChinaGuangzhou Institute of Cardiovascular Disease, The Second Affiliated Hospital, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou 510260, ChinaMore by Yu-Hong Cui
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- Hong-Wei Pan*
Hong-Wei Pan*Email: [email protected]Department of Ophthalmology, the First Affiliated Hospital, Jinan University, Guangzhou 510632, ChinaInstitute of Ophthalmology, School of Medicine, Jinan University, 601 West Huangpu Avenue, Guangzhou 510632, ChinaMore by Hong-Wei Pan
Abstract
Diabetic cataract is one of the most important causes of blindness worldwide. Cyanidin-3-O-glucoside (C3G) is found to exert beneficial effects on many diabetic complications. However, its effect on diabetic cataract is not well known. Herein, we investigated the effect of C3G on high glucose-induced lens epithelial cell (SRA01/04) apoptosis and cataract formation as well as the involved mechanisms. We found C3G (20 μM) could preserve cell viability in SRA01/04 cells exposed to high glucose (100 μM). Meanwhile, C3G inhibited SRA01/04 cell apoptosis and regulated the Bcl-2/Bax ratio. Additionally, C3G suppressed NF-κB activation and subsequent cyclooxygenases-2 (Cox-2) expression, which are associated with the protection against apoptosis. Moreover, C3G attenuated lens opacity and protein aggregation in lens culture exposed to high glucose. In conclusion, C3G protected against high glucose-induced SRA01/04 cell apoptosis and cataract formation, which indicated the potential protection of anthocyanins on diabetic cataract.
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