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Anthocyanins: From Sources and Bioavailability to Cardiovascular-Health Benefits and Molecular Mechanisms of Action

  • Irena Krga
    Irena Krga
    Centre of Research Excellence in Nutrition and Metabolism, Institute for Medical Research, University of Belgrade, 11000 Belgrade, Serbia
    INRA, UNH, CRNH Auvergne, Université Clermont Auvergne, F-63000 Clermont-Ferrand, France
    More by Irena Krga
  •  and 
  • Dragan Milenkovic*
    Dragan Milenkovic
    INRA, UNH, CRNH Auvergne, Université Clermont Auvergne, F-63000 Clermont-Ferrand, France
    Department of Internal Medicine, Division of Cardiovascular Medicine, School of Medicine, University of California Davis, Davis, California 95616, United States
    *E-mail: [email protected]. Tel.: +33(0)4 73 62 45 79. Fax: +33(0)4 73 62 46 38.
    More by Dragan Milenkovic
    Orcidhttp://orcid.org/0000-0001-6353-0912
Cite this: J. Agric. Food Chem. 2019, 67, 7, 1771–1783
Publication Date (Web):January 30, 2019
https://doi.org/10.1021/acs.jafc.8b06737
Copyright © 2019 American Chemical Society
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    Abstract

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    Anthocyanins are phytochemicals widely found in plant foods, with berries and fruit-derived beverages as the main dietary sources. Accumulating evidence suggests the positive role of anthocyanins in preserving cardiovascular health. Epidemiological data show an association between anthocyanin intake and lower risk of myocardial infarction and cardiovascular-disease-related mortality. Clinical studies report the beneficial effects of the consumption of different anthocyanin-rich sources on surrogate markers of cardiovascular risk. Animal and in vitro evidence suggest the protective role of anthocyanins in dysfunctions related to the development of cardiovascular diseases. Still, the underlying molecular mechanisms of anthocyanin action seem complex and are not entirely clear. This review aims to give a comprehensive update on anthocyanins and their cardioprotective properties. It provides information on their sources; quantities consumed through diet; absorption; bioavailability; cardiovascular properties; and underlying mechanisms of action, including their effects on gene and protein expression and their interactions with cell-signaling pathways and miRNAs.

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    • Summary of anthocyanin concentrations in plasma from selected human-bioavailability studies with anthocyanin-rich sources (PDF)

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