Adsorption Kinetics of Oppositely Charged Hard and Soft Nanoparticles with Phospholipid Membranes
- Marek Bekir*
Marek Bekir*Email: [email protected]. Phone: +49 331 977 5599.Stranski Laboratorium für Physikalische Chemie, Technische Universität Berlin, Straße des 17. Juni 124, 10623 Berlin, GermanyMore by Marek Bekir
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- Anja Hörmann
Anja HörmannStranski Laboratorium für Physikalische Chemie, Technische Universität Berlin, Straße des 17. Juni 124, 10623 Berlin, GermanyMore by Anja Hörmann
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- Christoph Brückner
Christoph BrücknerStranski Laboratorium für Physikalische Chemie, Technische Universität Berlin, Straße des 17. Juni 124, 10623 Berlin, GermanyMore by Christoph Brückner
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- Ingo Hoffmann
Ingo HoffmannStranski Laboratorium für Physikalische Chemie, Technische Universität Berlin, Straße des 17. Juni 124, 10623 Berlin, GermanyMore by Ingo Hoffmann
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- Sylvain Prévost
Sylvain PrévostStranski Laboratorium für Physikalische Chemie, Technische Universität Berlin, Straße des 17. Juni 124, 10623 Berlin, GermanyEuropean Synchrotron Radiation Facility (ESRF), avenue des Martyrs, CS 40220, 38043 Grenoble, Cedex 9, FranceMore by Sylvain Prévost
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- Michael Gradzielski*
Michael Gradzielski*Email: [email protected]. Phone: +49 30 314 24934. Fax: +49 30 314 26602.Stranski Laboratorium für Physikalische Chemie, Technische Universität Berlin, Straße des 17. Juni 124, 10623 Berlin, GermanyMore by Michael Gradzielski
Abstract
Nanoparticles (NPs) have great potential for biological applications as typically they exhibit strongly size-dependent properties. Specifically, the interaction of NPs with phospholipid membranes is significantly relevant to nanomedicine and the related field of nanotoxicology. Therefore, the investigation of interactions of NPs with model membranes is not only fundamentally important but also practically valuable to understand interactions of NPs with more complex cell membranes. Here, we report on the interaction of anionic vesicles of different charge densities and cationic SiO2 NPs, either covered by a bare surface functionalized with amino moieties (-NH2) or covered by poly[2-(dimethylamino) ethyl methacrylate]. We studied the kinetics of binding of NPs to the vesicle surface by time-resolved scattering experiments. A key result of the study is that binding is favored in the presence of electrostatic attraction, but the polymer layer decreases the binding rate drastically.
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