Nanomaterials Solutions for Contraception: Concerns, Advances, and Prospects
- Zhenning Su
Zhenning SuNHC Key Laboratory of Reproductive Health Engineering Technology Research, Department of Reproduction Physiology, National Research Institute for Family Planning, Beijing 100081, ChinaGraduate School of Peking Union Medical College, Beijing 100730, ChinaMore by Zhenning Su
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- Tian Diao
Tian DiaoNHC Key Laboratory of Reproductive Health Engineering Technology Research, Department of Reproduction Physiology, National Research Institute for Family Planning, Beijing 100081, ChinaGraduate School of Peking Union Medical College, Beijing 100730, ChinaAcademy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, ChinaMore by Tian Diao
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- Helen McGuire
Helen McGuireSchool of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2006, AustraliaMore by Helen McGuire
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- Cancan Yao
Cancan YaoNHC Key Laboratory of Reproductive Health Engineering Technology Research, Department of Reproduction Physiology, National Research Institute for Family Planning, Beijing 100081, ChinaGraduate School of Peking Union Medical College, Beijing 100730, ChinaMore by Cancan Yao
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- Lijun Yang
Lijun YangNHC Key Laboratory of Reproductive Health Engineering Technology Research, Department of Reproduction Physiology, National Research Institute for Family Planning, Beijing 100081, ChinaGraduate School of Peking Union Medical College, Beijing 100730, ChinaMore by Lijun Yang
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- Guo Bao
Guo BaoNHC Key Laboratory of Reproductive Health Engineering Technology Research, Department of Reproduction Physiology, National Research Institute for Family Planning, Beijing 100081, ChinaMore by Guo Bao
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- Xiaoxue Xu*
Xiaoxue Xu*Email: [email protected]School of Biomedical Engineering, Faculty of Engineering and Information Technology, University of Technology Sydney, Sydney, NSW 2007, AustraliaSchool of Science, Western Sydney University, Kumamoto NSW 2751, AustraliaMore by Xiaoxue Xu
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- Bin He*
Bin He*Email: [email protected]NHC Key Laboratory of Reproductive Health Engineering Technology Research, Department of Reproduction Physiology, National Research Institute for Family Planning, Beijing 100081, ChinaMore by Bin He
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- Yufeng Zheng*
Yufeng Zheng*Email: [email protected]School of Materials Science and Engineering, Peking University, Beijing 100871, ChinaInternational Research Organization for Advanced Science and Technology, Kumamoto University, 2-39-1 Kurokami, Chuo-Ku, Kumamoto 860-8555, JapanMore by Yufeng Zheng
Abstract
Preventing unintentional pregnancy is one of the goals of a global public health policy to minimize effects on individuals, families, and society. Various contraceptive formulations with high effectiveness and acceptance, including intrauterine devices, hormonal patches for females, and condoms and vasectomy for males, have been developed and adopted over the last decades. However, distinct breakthroughs of contraceptive techniques have not yet been achieved, while the associated long-term adverse effects are insurmountable, such as endocrine system disorder along with hormone administration, invasive ligation, and slowly restored fertility after removal of intrauterine devices. Spurred by developments of nanomaterials and bionanotechnologies, advanced contraceptives could be fulfilled via nanomaterial solutions with much safer and more controllable and effective approaches to meet various and specific needs for women and men at different reproductive stages. Nanomedicine techniques have been extended to develop contraceptive methods, such as the targeted drug delivery and controlled release of hormone using nanocarriers for females and physical stimulation assisted vasectomy using functional nanomaterials via photothermal treatment or magnetic hyperthermia for males. Nanomaterial solutions for advanced contraceptives offer significantly improved biosafety, noninvasive administration, and controllable reversibility. This review summarizes the nanomaterial solutions to female and male contraceptives including the working mechanisms, clinical concerns, and their merits and demerits. This work also reviewed the nanomaterials that have been adopted in contraceptive applications. In addition, we further discuss safety considerations and future perspectives of nanomaterials in nanostrategy development for next-generation contraceptives. We expect that nanomaterials would potentially replace conventional materials for contraception in the near future.
Cited By
This article is cited by 1 publications.
- Biswajeet Acharya, Amulyaratna Behera, Suchismeeta Behera, Srikanta Moharana. Recent Advances in Nanotechnology-Based Drug Delivery Systems for the Diagnosis and Treatment of Reproductive Disorders. ACS Applied Bio Materials 2024, 7 (3) , 1336-1361. https://doi.org/10.1021/acsabm.3c01064