ACS Publications. Most Trusted. Most Cited. Most Read

OR SEARCH CITATIONS

My Activity
Publications
CONTENT TYPES

Figure 1Loading Img
Download Hi-Res ImageDownload to MS-PowerPointCite This:ACS Nano 2017, 11, 7, 7164-7176
RETURN TO ISSUEPREVArticleNEXT

Polyoxometalate-Based Radiosensitization Platform for Treating Hypoxic Tumors by Attenuating Radioresistance and Enhancing Radiation Response

View Author Information
† CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics and National Center for Nanoscience Technology of China, Chinese Academy of Sciences, Beijing 100049, People’s Republic of China
‡ College of Materials Science and Optoelectronic Technology, University of Chinese Academy of Sciences, Beijing 100049, People’s Republic of China
§ Key Laboratory of Green Process and Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, People’s Republic of China
∥ College of Chemistry and Environment Protection Engineering, Southwest Minzu University, Chengdu 610041, People’s Republic of China
*E-mail: [email protected]
*E-mail: [email protected]
*E-mail: [email protected]
*E-mail: [email protected]
Cite this: ACS Nano 2017, 11, 7, 7164–7176
Publication Date (Web):June 22, 2017
https://doi.org/10.1021/acsnano.7b03037
Copyright © 2017 American Chemical Society
Request reuse permissions

    Article Views

    5678

    Altmetric

    -

    Citations

    165
    LEARN ABOUT THESE METRICS
    Other access options
    Get e-Alerts
    Supporting Info (1)»
    SUBJECTS:

    Abstract

    Abstract Image

    Radioresistance is one of the undesirable impediments in hypoxic tumors, which sharply diminishes the therapeutic effectiveness of radiotherapy and eventually results in the failure of their treatments. An attractive strategy for attenuating radioresistance is developing an ideal radiosensitization system with appreciable radiosensitization capacity to attenuate tumor hypoxia and reinforce radiotherapy response in hypoxic tumors. Therefore, we describe the development of Gd-containing polyoxometalates-conjugated chitosan (GdW10@CS nanosphere) as a radiosensitization system for simultaneous extrinsic and intrinsic radiosensitization, by generating an overabundance of cytotoxic reactive oxygen species (ROS) using high-energy X-ray stimulation and mediating the hypoxia-inducible factor-1a (HIF-1a) siRNA to down-regulate HIF-1α expression and suppress broken double-stranded DNA self-healing. Most importantly, the GdW10@CS nanospheres have the capacity to promote the exhaustion of intracellular glutathione (reduced GSH) by synergy W6+-triggered GSH oxidation for sufficient ROS generation, thereby facilitating the therapeutic efficiency of radiotherapy. As a result, the as-synthesized GdW10@CS nanosphere can overcome radioresistance of hypoxic tumors through a simultaneous extrinsic and intrinsic strategy to improve radiosensitivity. We have demonstrated GdW10@CS nanospheres with special radiosensitization behavior, which provides a versatile approach to solve the critical radioresistance issue of hypoxic tumors.

    KEYWORDS:

    Read this article

    To access this article, please review the available access options below.

    Get instant access

    Purchase Access

    Read this article for 48 hours. Check out below using your ACS ID or as a guest.

    Recommended

    Access through Your Institution

    You may have access to this article through your institution.

    Your institution does not have access to this content. You can change your affiliated institution below.

    Supporting Information

    ARTICLE SECTIONS
    Jump To

    The Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acsnano.7b03037.

    • EDS spectra of GdW10@CS nanospheres, DLS assessments of GdW10@CS nanospheres dispersed in DMEM, H&E-stained images of main organs, blood chemistry analysis and hematological parameters of mice as a function of time, hematological parameters of mice after various administrations, in vitro cytotoxicity assay of GdW10@CSsiRNA and CoCl2 under hypoxia, sensitizer enhancement ratio of GdW10@CS and GdW10@CSsiRNA, in vitro colony formation assay of GdW10@CS nanospheres in HeLa cells under hypoxia, tumor images of different mice, biodistribution of GdW10@CS nanospheres in vivo, H&E-stained images of main organs under different treatments, MR and CT imaging in vitro, MR and CT imaging in vivo (PDF)

    Terms & Conditions

    Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses). Permission may be obtained from ACS for other uses through requests via the RightsLink permission system: http://pubs.acs.org/page/copyright/permissions.html.

    Cited By

    This article is cited by 165 publications.

    1. Yang Chen, Yong Deng, Yiran Li, Yulin Qin, Zhiguo Zhou, Hong Yang, Yun Sun. Oxygen-Independent Radiodynamic Therapy: Radiation-Boosted Chemodynamics for Reprogramming the Tumor Immune Environment and Enhancing Antitumor Immune Response. ACS Applied Materials & Interfaces 2024, 16 (17) , 21546-21556. https://doi.org/10.1021/acsami.4c00793
    2. Lihua Shao, Xueyuan Wang, Xiao Du, Shaoping Yin, Yun Qian, Yawen Yao, Lin Yang. Application of Multifunctional Nanozymes in Tumor Therapy. ACS Omega 2024, 9 (14) , 15753-15767. https://doi.org/10.1021/acsomega.4c00258
    3. Hongwei Liao, Shengfei Yang, Zeyu Liang, Lin Xiao, Shangzhi Xie, Peihua Lin, Fan Xia, Chunyan Fang, Qian Chen, Daishun Ling, Fangyuan Li. A Cancer Cell Selective Replication Stress Nano Amplifier Promotes Replication Fork Catastrophe to Overcome Radioresistance. ACS Nano 2023, 17 (18) , 18548-18561. https://doi.org/10.1021/acsnano.3c06774
    4. Guoyuan Ren, Mingju Lu, Zhiqiang Zhao, Fengjuan Qin, Kai Li, Wenxing Chen, Yuqing Lin. Cobalt Single-Atom Nanozyme Co-Administration with Ascorbic Acid Enables Redox Imbalance for Tumor Catalytic Ablation. ACS Biomaterials Science & Engineering 2023, 9 (2) , 1066-1076. https://doi.org/10.1021/acsbiomaterials.2c01301
    5. Shaodian Zhang, Yanxian Wu, Jiangkun Yu, Chunjie Ma, Yangyun Wang, Yong Wang, Liubing Li, Leshuai W. Zhang. Gadolinium-Bisphosphonate Nanoparticle-Based Low-Dose Radioimmunotherapy for Osteosarcoma. ACS Biomaterials Science & Engineering 2022, 8 (12) , 5329-5337. https://doi.org/10.1021/acsbiomaterials.2c00880
    6. Yu Wang, Xueping Kong, Fei Li, Bao Li, Lixin Wu, Kai Chen, Yuqing Wu. Mo154 Synergistically Enhanced Antibiofilm and Antibacterial Effects of Spermine via Coassembly. ACS Applied Bio Materials 2022, 5 (11) , 5281-5288. https://doi.org/10.1021/acsabm.2c00692
    7. Yin Wang, Weiwei Zeng, Huazhen Liang, Xixi Wu, Hanyue Li, Ting Chen, Mi Yang, Xiaoqing Wang, Wen Li, Fan Zhang, Qianqian Li, Feng Ye, Jian Guan, Lin Mei. Targeted Wolfram-Doped Polypyrrole for Photonic Hyperthermia-Synergized Radiotherapy. ACS Applied Materials & Interfaces 2022, 14 (45) , 50557-50568. https://doi.org/10.1021/acsami.2c15015
    8. Bin Liu, Xiaolei Zhang, Jinkai Li, Shu Yao, Yizhong Lu, Bingqiang Cao, Zongming Liu. X-ray-Triggered CO Release Based on GdW10/MnBr(CO)5 Nanomicelles for Synergistic Radiotherapy and Gas Therapy. ACS Applied Materials & Interfaces 2022, 14 (6) , 7636-7645. https://doi.org/10.1021/acsami.1c22575
    9. Maryam Ramezani-Aliakbari, Jaleh Varshosaz, Hojjat Sadeghi-aliabadi, Farshid Hassanzadeh, Mahboubeh Rostami. Biotin-Targeted Nanomicellar Formulation of an Anderson-Type Polyoxomolybdate: Synthesis and In Vitro Cytotoxicity Evaluations. Langmuir 2021, 37 (21) , 6475-6489. https://doi.org/10.1021/acs.langmuir.1c00623
    10. Xiaotong Cheng, Hai-Dong Xu, Huan-Huan Ran, Gaolin Liang, Fu-Gen Wu. Glutathione-Depleting Nanomedicines for Synergistic Cancer Therapy. ACS Nano 2021, 15 (5) , 8039-8068. https://doi.org/10.1021/acsnano.1c00498
    11. Qiang Liu, Ying Shi, Yu Chong, Cuicui Ge. Pharmacological Ascorbate Promotes the Tumor Radiosensitization of Au@Pd Nanoparticles with Simultaneous Protection of Normal Tissues. ACS Applied Bio Materials 2021, 4 (2) , 1843-1851. https://doi.org/10.1021/acsabm.0c01537
    12. Yuanyuan Yang, Yingjie Yu, Hao Chen, Xiangxi Meng, Wen Ma, Meng Yu, Ziyuan Li, Changhui Li, Haile Liu, Xiaodong Zhang, Haihua Xiao, Zhiqiang Yu. Illuminating Platinum Transportation while Maximizing Therapeutic Efficacy by Gold Nanoclusters via Simultaneous Near-Infrared-I/II Imaging and Glutathione Scavenging. ACS Nano 2020, 14 (10) , 13536-13547. https://doi.org/10.1021/acsnano.0c05541
    13. Hongjun Zhuang, Mengyao Zhao, Shenglong Ding, Lingyan Liu, Wei Yuan, Liping Jiang, Xuemin Han, Libo Jiang, Tao Yi. Multifunctional Smart Yolk–Shell Nanostructure with Mesoporous MnO2 Shell for Enhanced Cancer Therapy. ACS Applied Materials & Interfaces 2020, 12 (35) , 38906-38917. https://doi.org/10.1021/acsami.0c08389
    14. Huimin Wang, Yuqi Chen, Jinhua Shang, Hong Wang, Min Pan, Xiaoqing Liu, Xiang Zhou, Fuan Wang. Multifunctional Hypoxia-Involved Gene Silencing Nanoplatform for Sensitizing Photochemotherapy. ACS Applied Materials & Interfaces 2020, 12 (31) , 34588-34598. https://doi.org/10.1021/acsami.0c08315
    15. Zheng Wang, Zhi-min Chang, Dan Shao, Fan Zhang, Fangman Chen, Li Li, Ming-feng Ge, Rui Hu, Xiao Zheng, Yingshuai Wang, Wen-fei Dong. Janus Gold Triangle-Mesoporous Silica Nanoplatforms for Hypoxia-Activated Radio-Chemo-Photothermal Therapy of Liver Cancer. ACS Applied Materials & Interfaces 2019, 11 (38) , 34755-34765. https://doi.org/10.1021/acsami.9b12879
    16. Yinchu Ma, Yangyang Zhao, Naveen Kumar Bejjanki, Xinfeng Tang, Wei Jiang, Jiaxiang Dou, Malik Ihsanullah Khan, Qin Wang, Jinxing Xia, Hang Liu, Ye-Zi You, Guoqing Zhang, Yucai Wang, Jun Wang. Nanoclustered Cascaded Enzymes for Targeted Tumor Starvation and Deoxygenation-Activated Chemotherapy without Systemic Toxicity. ACS Nano 2019, 13 (8) , 8890-8902. https://doi.org/10.1021/acsnano.9b02466
    17. Guangxu Lan, Kaiyuan Ni, Samuel S. Veroneau, Taokun Luo, Eric You, Wenbin Lin. Nanoscale Metal–Organic Framework Hierarchically Combines High-Z Components for Multifarious Radio-Enhancement. Journal of the American Chemical Society 2019, 141 (17) , 6859-6863. https://doi.org/10.1021/jacs.9b03029
    18. Bowen Yang, Yu Chen, Jianlin Shi. Reactive Oxygen Species (ROS)-Based Nanomedicine. Chemical Reviews 2019, 119 (8) , 4881-4985. https://doi.org/10.1021/acs.chemrev.8b00626
    19. Jing Ruan, Ying Wang, Fang Li, Renbing Jia, Guangming Zhou, Chunlin Shao, Liqi Zhu, Malin Cui, Da-Peng Yang, Shengfang Ge. Graphene Quantum Dots for Radiotherapy. ACS Applied Materials & Interfaces 2018, 10 (17) , 14342-14355. https://doi.org/10.1021/acsami.7b18975
    20. Piao Zhu, Yu Chen, Jianlin Shi. Nanoenzyme-Augmented Cancer Sonodynamic Therapy by Catalytic Tumor Oxygenation. ACS Nano 2018, 12 (4) , 3780-3795. https://doi.org/10.1021/acsnano.8b00999
    21. Zichao Luo, Duo Mao, Xinchao Li, Jing Luo, Changyang Gong, Xiaogang Liu. Lanthanide-based nanoparticles for cancer phototherapy. Coordination Chemistry Reviews 2024, 508 , 215773. https://doi.org/10.1016/j.ccr.2024.215773
    22. Mohamed J. Saadh, Mohammed Ahmed Mustafa, Laith Yassen Qassem, Ghadir Kamil Ghadir, Mohd Alaraj, Mahmood Hasen Shuhata Alubiady, Salah Hassan Zain Al-Abdeen, Hussein Ghafel Shakier, Mohammad Y. Alshahrani, Ahmed Hussein Zwamel. Targeting hypoxic and acidic tumor microenvironment by nanoparticles: A review. Journal of Drug Delivery Science and Technology 2024, 96 , 105660. https://doi.org/10.1016/j.jddst.2024.105660
    23. Minle Chen, Qianru Zhu, Zhenzhen Zhang, Qiushui Chen, Huanghao Yang. Recent Advances in Photosensitizer Materials for Light‐Mediated Tumor Therapy. Chemistry – An Asian Journal 2024, 49 https://doi.org/10.1002/asia.202400268
    24. Jinyan Lin, Yueyang He, Yang Li, Jianwu Chen, Xiaolong Liu. Oxygen‐Evolving Radiotherapy‐Radiodynamic Therapy Synergized with NO Gas Therapy by Cerium‐Based Rare‐Earth Metal‐Porphyrin Framework. Small 2024, 33 https://doi.org/10.1002/smll.202310957
    25. Kheibar Dashtian, Samaneh Shahsavarifar, Muhammad Usman, Yvonne Joseph, Mohammad Reza Ganjali, Zongyou Yin, Mehdi Rahimi-Nasrabadi. A comprehensive review on advances in polyoxometalate based materials for electrochemical water splitting. Coordination Chemistry Reviews 2024, 504 , 215644. https://doi.org/10.1016/j.ccr.2023.215644
    26. Qilan Xu, Li Zhang, Yuhui Liu, Ling Cai, Liuzhu Zhou, Huijun Jiang, Jin Chen. Encapsulating MoS2-nanoflowers conjugated with chitosan oligosaccharide into electrospun nanofibrous scaffolds for photothermal inactivation of bacteria. Journal of Nanostructure in Chemistry 2024, 14 (2) , 137-151. https://doi.org/10.1007/s40097-022-00494-1
    27. Zhengya Yue, Jialun Li, Minglu Tang, Tiedong Sun, Chunxia Chen, Zhiguang Wu. Nanozyme‐based Clusterphene for Enhanced Electrically Catalytic Cancer Therapy. Advanced Healthcare Materials 2024, 13 (9) https://doi.org/10.1002/adhm.202303222
    28. Rui Luo, Hao Le, Qinjie Wu, Changyang Gong. Nanoplatform‐Based In Vivo Gene Delivery Systems for Cancer Therapy. Small 2024, 18 https://doi.org/10.1002/smll.202312153
    29. Bo Zhao, Xiuli Hu, Lu Chen, Xin Wu, Donghui Wang, Hongshui Wang, Chunyong Liang. Fe3O4@TiO2 Microspheres: Harnessing O2 Release and ROS Generation for Combination CDT/PDT/PTT/Chemotherapy in Tumours. Nanomaterials 2024, 14 (6) , 498. https://doi.org/10.3390/nano14060498
    30. Xianzhou Huang, Tao He, Xiuqi Liang, Zhongzheng Xiang, Chao Liu, Shiyao Zhou, Rui Luo, Liping Bai, Xiaorong Kou, Xinchao Li, Rui Wu, Xinyu Gou, Xinyue Wu, Dongxue Huang, Wangxian Fu, Yingjie Li, Ruhan Chen, Ningyue Xu, Yixi Wang, Hao Le, Tao Chen, Yangsong Xu, Yuting Tang, Changyang Gong. Advances and applications of nanoparticles in cancer therapy. MedComm – Oncology 2024, 3 (1) https://doi.org/10.1002/mog2.67
    31. Vamangi M. Pandya, Dweipayan Goswami, Sachin A. Joshi. Biopolymer hydrogel matrices for the stabilization and in-vitro delivery of anti-cancer polyoxometalate [CoW 11 O 39 (CpTi)] 7−. Journal of Macromolecular Science, Part A 2024, 6 , 1-12. https://doi.org/10.1080/10601325.2024.2308547
    32. Ling-Cheng Meng, Quan-Ping Zhang, Fu-Han Mai, Rui Wang, Deng-Chao Hu, Gui-Lin Li, Yong Jiang, Lei Guo, Jia-Le Li, Peng-Qing Liu, Yuan-Lin Zhou. Synergistic effects of polymaleic acid and di(dioctylpyrophosphato) ethylene titanate on B4C modification in highly filled polymer fibers for improved neutron protection safety and wear comfort of articles. Applied Materials Today 2024, 36 , 102040. https://doi.org/10.1016/j.apmt.2023.102040
    33. Bole Li, Xiaotong Xu, Yanfei Lv, Zhaohui Wu, Lei He, Yu‐Fei Song. Polyoxometalates as Potential Artificial Enzymes toward Biological Applications. Small 2024, 20 (3) https://doi.org/10.1002/smll.202305539
    34. Wenjing Xiao, Lin Zhao, Yang Sun, Xiao Yang, Qinrui Fu. Stimuli‐Responsive Nanoradiosensitizers for Enhanced Cancer Radiotherapy. Small Methods 2024, 8 (1) https://doi.org/10.1002/smtd.202301131
    35. Dandan Sun, Wenjia Tan, Jianan Zhao, Yafei Tian, Siqi Li, Zhiqi Zhang, Xinzhe Dong, Xiaonan Liu, Na Liu, Ping Jiao, Jie Ma. Delivery of Nucleic Acid Drugs for Tumor Therapy: Opportunities and Challenges. Fundamental Research 2024, 24 https://doi.org/10.1016/j.fmre.2023.11.020
    36. Fahimeh Aminolroayaei, Ali Mehri, Daryoush Shahbazi-Gahrouei, Mahboubeh Rostami. Polyoxometalates as next-generation of theragnostic gadgets in cancer. Reviews in Inorganic Chemistry 2023, Article ASAP.
    37. Hongbo Gao, Li Sun, Dalong Ni, Libo Zhang, Han Wang, Wenbo Bu, Jinjin Li, Qianwen Shen, Ya Wang, Yanyan Liu, Xiangpeng Zheng. Regulating electron transportation by tungsten oxide nanocapacitors for enhanced radiation therapy. Journal of Nanobiotechnology 2023, 21 (1) https://doi.org/10.1186/s12951-023-01962-8
    38. Zhengya Yue, Runjie Wang, Jialun Li, Minglu Tang, Li Yang, Hao Gu, Xijin Wang, Tiedong Sun. Recent Advances in Polyoxometalate Based Nanoplatforms Mediated Reactive Oxygen Species Cancer Therapy. Chemistry – An Asian Journal 2023, 18 (22) https://doi.org/10.1002/asia.202300749
    39. Ryan Blanchard, Isaac Adjei. Engineering the glioblastoma microenvironment with bioactive nanoparticles for effective immunotherapy. RSC Advances 2023, 13 (45) , 31411-31425. https://doi.org/10.1039/D3RA01153D
    40. Jiaojiao Hao, Zhuo Song, Jiayi Su, Longjie Li, Lijian Zou, Kun Zou. The PRX-1/TLR4 axis promotes hypoxia-induced radiotherapy resistance in non-small cell lung cancer by targeting the NF-κB/p65 pathway. Cellular Signalling 2023, 110 , 110806. https://doi.org/10.1016/j.cellsig.2023.110806
    41. Shahrzad Mahvash, Vajihe Azimian Zavareh, Somayeh Taymouri, Mina Mirian, Maryam Ramezani-Aliakbari, Fatemeh Dousti, Mahboubeh Rostami. Anderson-type manganese polyoxomolybdate hybrid nanocomposite for boosting drug delivery against breast cancer. Journal of Drug Delivery Science and Technology 2023, 87 , 104778. https://doi.org/10.1016/j.jddst.2023.104778
    42. Shan Lei, Han Yang, Jiaxin Li, Yao Li, Li Wang, Bingnian Chen, Jian Li. A study of the antioxidant properties of Keggin-type polyoxometalates. Dalton Transactions 2023, 52 (28) , 9673-9683. https://doi.org/10.1039/D3DT01361H
    43. Marketa Kolarikova, Barbora Hosikova, Hanna Dilenko, Katerina Barton‐Tomankova, Lucie Valkova, Robert Bajgar, Lukas Malina, Hana Kolarova. Photodynamic therapy: Innovative approaches for antibacterial and anticancer treatments. Medicinal Research Reviews 2023, 43 (4) , 717-774. https://doi.org/10.1002/med.21935
    44. Xiangyu Jin, Yinchu Ma, Didi Liu, Yi Huang. Role of pyroptosis in the pathogenesis and treatment of diseases. MedComm 2023, 4 (3) https://doi.org/10.1002/mco2.249
    45. Dongzhi Xue, Yue Cao, Yinghui Wang, Zhijia Lv, Longhai Jin, Songtao Zhang, Wanying Li, Junduo Wu, Jianhua Liu, Shuyan Song, Xiaogang Liu, Hongjie Zhang. An efficient reactive oxygen species/reactive nitrogen species generator for dual imaging-guided orthotopic glioblastoma therapy through intrathecal delivery. Nano Today 2023, 50 , 101886. https://doi.org/10.1016/j.nantod.2023.101886
    46. Li Wang, Liang Xiao, Zhengyang Zhao, Kai Zhong, Weiliang Zhu, Hao Liu, Xiaoqiu Li. Hybrid transcytosis nanopomegranates for sensitizing breast cancer radiotherapy in deep tumor tissue. Nano Research 2023, 16 (5) , 7260-7268. https://doi.org/10.1007/s12274-023-5375-2
    47. Wenyao Zhen, Ralph R. Weichselbaum, Wenbin Lin. Nanoparticle‐Mediated Radiotherapy Remodels the Tumor Microenvironment to Enhance Antitumor Efficacy. Advanced Materials 2023, 35 (21) https://doi.org/10.1002/adma.202206370
    48. Munima Haque, Md Salman Shakil, Kazi Mustafa Mahmud. The Promise of Nanoparticles-Based Radiotherapy in Cancer Treatment. Cancers 2023, 15 (6) , 1892. https://doi.org/10.3390/cancers15061892
    49. Da-Gui Zhang, Biao-Qi Chen, Yu-Jing Pan, Hao Liu, Yu-Hong Shi, Lin-Fei Chen, Ranjith Kumar Kankala, Shi-Bin Wang, Ai-Zheng Chen. Albumin-based smart nanoplatform for ultrasound-mediated enhanced chemo‐sonodynamic combination therapy. Materials & Design 2023, 227 , 111794. https://doi.org/10.1016/j.matdes.2023.111794
    50. Mohammad Varzandeh, Leila Sabouri, Vahid Mansouri, Maliheh Gharibshahian, Nima Beheshtizadeh, Michael R. Hamblin, Nima Rezaei. Application of nano‐radiosensitizers in combination cancer therapy. Bioengineering & Translational Medicine 2023, 7 https://doi.org/10.1002/btm2.10498
    51. Meijuan He, Tingting Xiao, Yihui Wang, Hongwei Yu, Zilin Wang, Xiangyang Shi, Han Wang. Multifunctional PVCL nanogels enable magnetic resonance imaging and immunostimulated radiotherapy of orthotopic glioblastoma. Chemical Engineering Journal 2023, 453 , 139634. https://doi.org/10.1016/j.cej.2022.139634
    52. Cheng Wang, Lingyun Wu, Huili Yuan, Hao Yu, Jiaqi Xu, Si Chen, Senxiang Yan, Xu Wang. A powerful antitumor “trident”: the combination of radio-, immuno- and anti-angiogenesis therapy based on mesoporous silica single coated gold nanoparticles. Journal of Materials Chemistry B 2023, 11 (4) , 879-889. https://doi.org/10.1039/D2TB02046G
    53. Yihan Wang, Yizhen Wei, Yichun Wu, Yue Zong, Yingying Song, Shengyan Pu, Wenwen Wu, Yun Zhou, Jun Xie, Haitao Yin. Multifunctional Nano-Realgar Hydrogel for Enhanced Glioblastoma Synergistic Chemotherapy and Radiotherapy: A New Paradigm of an Old Drug. International Journal of Nanomedicine 2023, Volume 18 , 743-763. https://doi.org/10.2147/IJN.S394377
    54. Sneha Dutta, Sanjeeb Kumar Sahoo. Hypoxic Tumor Microenvironment: Driver for Cancer Progression. 2023, 65-88. https://doi.org/10.1007/978-981-99-0313-9_4
    55. Chenglu Gu, Zhiqiang Wang, Yawen Pan, Shuang Zhu, Zhanjun Gu. Tungsten‐based Nanomaterials in the Biomedical Field: A Bibliometric Analysis of Research Progress and Prospects. Advanced Materials 2023, 35 (1) https://doi.org/10.1002/adma.202204397
    56. Aashna Srivastava, Dharmendra Prajapati, Sachidanand Singh, Tanvi Jain. Novel Strategies in Radiotherapy to Reduce Hypoxia Using Nanomaterials. 2023, 115-129. https://doi.org/10.1007/978-981-99-1718-1_7
    57. Hu Liu, Han Wang, Dalong Ni, Youjia Xu. Lactic acid modified rare earth-based nanomaterials for enhanced radiation therapy by disturbing the glycolysis. Journal of Nanobiotechnology 2022, 20 (1) https://doi.org/10.1186/s12951-022-01694-1
    58. Jiale Liu, Mengyao Huang, Xinyu Zhang, Zhongyu Hua, Zeran Feng, Yi Dong, Tiedong Sun, Xiao Sun, Chunxia Chen. Polyoxometalate nanomaterials for enhanced reactive oxygen species theranostics. Coordination Chemistry Reviews 2022, 472 , 214785. https://doi.org/10.1016/j.ccr.2022.214785
    59. Qinghe Wu, Mengfei Hou, Pengli Zhang, Yifei Jiang, Meirong Liu, Liqin Xiong, Wangxi Hai, Min Zhang, Xiao Li, Biao Li, Chunfu Zhang. Self-cascade nanohybrids boost cell ferroptosis stress for tumor radiosensitization therapy. Applied Materials Today 2022, 29 , 101558. https://doi.org/10.1016/j.apmt.2022.101558
    60. Guanghong Luo, Zihuang Li, Jiezhou Zheng, Hongli Yang, Xianming Li, Xiao Guishan, Yanhong Duo. Recent progresses on radiotherapeutics-based treatment of cancer with two-dimensional nanomaterials. Applied Materials Today 2022, 29 , 101584. https://doi.org/10.1016/j.apmt.2022.101584
    61. Yuanbo Pan, Wei Tang, Wenpei Fan, Jianmin Zhang, Xiaoyuan Chen. Development of nanotechnology-mediated precision radiotherapy for anti-metastasis and radioprotection. Chemical Society Reviews 2022, 51 (23) , 9759-9830. https://doi.org/10.1039/D1CS01145F
    62. Juan Pablo González-Castillo, Esdras Alfredo Zamora-Morán, Lourdes Rodriguez-Fragoso. Advances in Graphene Platforms for Drug Delivery in Cancer and Its Biocompatibility. 2022https://doi.org/10.5772/intechopen.103688
    63. Xiaohui Xiao, Yupeng Wang, Jieyao Chen, Peng Qin, Peiyao Chen, Dongfang Zhou, Yue Pan. Self-targeting platinum(IV) amphiphilic prodrug nano-assembly as radiosensitizer for synergistic and safe chemoradiotherapy of hepatocellular carcinoma. Biomaterials 2022, 289 , 121793. https://doi.org/10.1016/j.biomaterials.2022.121793
    64. Haili Yan, Long Gao, You Liao, Dongmei Wang, Duiping Feng, Jianguo Li, Jiangfeng Du, Zhanjun Gu, Hui Zhang. Hexagonal NaxWO3 nanocrystals with reversible valence states for microwave thermal and chemodynamic combined cancer therapy. Chemical Engineering Journal 2022, 446 , 136869. https://doi.org/10.1016/j.cej.2022.136869
    65. Dnyaneshwar Kalyane, Devendra Choudhary, Suryanarayana Polaka, Hanmant Goykar, Tukaram Karanwad, Kuldeep Rajpoot, Rakesh Kumar Tekade. Reactive oxygen nano-generators for cancer therapy. Progress in Materials Science 2022, 130 , 100974. https://doi.org/10.1016/j.pmatsci.2022.100974
    66. Jinfeng Lin, Mingming Yin, Xiaoming Liu, Fanling Meng, Liang Luo. Nanomaterials Based on Functional Polymers for Sensitizing Cancer Radiotherapy. Macromolecular Rapid Communications 2022, 43 (18) https://doi.org/10.1002/marc.202200194
    67. Mohsen Doust Mohammadi, Faheem Abbas, Hitler Louis, Gideon E. Mathias, Tomsmith O. Unimuke. Trapping of CO, CO2, H2S, NH3, NO, NO2, and SO2 by polyoxometalate compound. Computational and Theoretical Chemistry 2022, 1215 , 113826. https://doi.org/10.1016/j.comptc.2022.113826
    68. Jinxing Huang, Kai Xiao. Nanoparticles-Based Strategies to Improve the Delivery of Therapeutic Small Interfering RNA in Precision Oncology. Pharmaceutics 2022, 14 (8) , 1586. https://doi.org/10.3390/pharmaceutics14081586
    69. Peng Lin, Junpeng Shi, Liyan Ming, Yangyang Sheng, Liang Song, Maochun Hong, Yun Zhang. An intelligent persistent luminescence nanoplatform with high-efficiency O2 utilization for continuous hypoxic tumors treatment. Chemical Engineering Journal 2022, 442 , 135638. https://doi.org/10.1016/j.cej.2022.135638
    70. Lanqiong Zhang, Xiaomeng Du, Qian Li, Lili Qian, Jiawei Chen, Chaoyong Liu, Qingsong Yu, Zhihua Gan. A Multimodal Therapeutic Nanoplatform Overcoming Tumor Hypoxia Heterogeneity for Improved Tumor Chemoradiotherapy. Advanced Functional Materials 2022, 32 (34) , 2204629. https://doi.org/10.1002/adfm.202204629
    71. Yan Yan, Houli Li, Hongping Yao, Xiaoliang Cheng. Nanodelivery Systems Delivering Hypoxia-Inducible Factor-1 Alpha Short Interfering RNA and Antisense Oligonucleotide for Cancer Treatment. Frontiers in Nanotechnology 2022, 4 https://doi.org/10.3389/fnano.2022.932976
    72. Xiaofeng Fan, Wei Pang, Hao Feng, Ruiyi Zhang, Wentao Zhu, Qiushi Wang, Jun Miao, Yiwen Li, Yanjun Liu, Xiaoqian Xu. Light-guided tumor diagnosis and therapeutics: From nanoclusters to polyoxometalates. Chinese Chemical Letters 2022, 33 (6) , 2783-2798. https://doi.org/10.1016/j.cclet.2021.12.057
    73. Fanny Delille, Yuzhou Pu, Nicolas Lequeux, Thomas Pons. Designing the Surface Chemistry of Inorganic Nanocrystals for Cancer Imaging and Therapy. Cancers 2022, 14 (10) , 2456. https://doi.org/10.3390/cancers14102456
    74. Weiyong Tao, Zhan Tuo, Feige Wu, Ketao Mu, Cunjing Xu, Yuxiao Shi, Zeyu Sun, Yifan Wang, Yan Li, Zhenyu Zhong, Lei Zhou, Jianglin Wang, Jie Liu, Yingying Du, Shengmin Zhang. Albumin-assembled copper-bismuth bimetallic sulfide bioactive nanosphere as an amplifier of oxidative stress for enhanced radio-chemodynamic combination therapy. Regenerative Biomaterials 2022, 9 https://doi.org/10.1093/rb/rbac045
    75. Xiaojuan Zhang, Chuanchuan He, Guangya Xiang. Engineering nanomedicines to inhibit hypoxia-inducible Factor-1 for cancer therapy. Cancer Letters 2022, 530 , 110-127. https://doi.org/10.1016/j.canlet.2022.01.012
    76. Qinyanqiu Xiang, Chao Yang, Yuanli Luo, Fan Liu, Jun Zheng, Weiwei Liu, Haitao Ran, Yang Sun, Jianli Ren, Zhigang Wang. Near‐Infrared II Nanoadjuvant‐Mediated Chemodynamic, Photodynamic, and Photothermal Therapy Combines Immunogenic Cell Death with PD‐L1 Blockade to Enhance Antitumor Immunity. Small 2022, 18 (13) https://doi.org/10.1002/smll.202107809
    77. Jieyao Chen, Haiyue Dong, Lu Bai, Linrong Li, Sijie Chen, Xin Tian, Yue Pan. Multifunctional high- Z nanoradiosensitizers for multimodal synergistic cancer therapy. Journal of Materials Chemistry B 2022, 10 (9) , 1328-1342. https://doi.org/10.1039/D1TB02524D
    78. Manuel Aureliano. The Future Is Bright for Polyoxometalates. BioChem 2022, 2 (1) , 8-26. https://doi.org/10.3390/biochem2010002
    79. Hamid Taghiyar, Bahram Yadollahi, Seyed Jamal Moshtaghian, Ardeshir Talebi, Abolghasem Abbasi Kajani. PMMA nanofibers containing Keplerate-type polyoxometalate and metronidazole: Preparation and wound-healing effect in a rat model. Journal of Drug Delivery Science and Technology 2022, 69 , 103140. https://doi.org/10.1016/j.jddst.2022.103140
    80. Yelin Wu, Yanli Li, Guanglei Lv, Wenbo Bu. Redox dyshomeostasis strategy for tumor therapy based on nanomaterials chemistry. Chemical Science 2022, 13 (8) , 2202-2217. https://doi.org/10.1039/D1SC06315D
    81. Lixia Chen, Yang Zhang, Xinming Zhang, Ruijuan Lv, Rongtian Sheng, Ruimeng Sun, Ting Du, Yuhan Li, Yanfei Qi. A GdW10@PDA-CAT Sensitizer with High-Z Effect and Self-Supplied Oxygen for Hypoxic-Tumor Radiotherapy. Molecules 2022, 27 (1) , 128. https://doi.org/10.3390/molecules27010128
    82. Neha Suyog Potnis, Akbar Ali, Suchetan Pal. Recent Developments in ROS-Based Nanotherapeutic Modalities in Preclinical Cancer Treatment. 2022, 1-18. https://doi.org/10.1007/978-981-16-1247-3_261-1
    83. Faezeh Mozafari, Hamid Rashidzadeh, Mohammadreza Ghaffarlou, Marziyeh Salehiabar, Yavuz Nuri Ertas, Ali Ramazani, Morteza Abazari, Mohammad-Amin Rahmati, Yasir Javed, Surender K. Sharma, Hossein Danafar. ROS-Based Cancer Radiotherapy. 2022, 265-309. https://doi.org/10.1007/978-3-031-04071-9_10
    84. Qianqian Sun, Zhao Wang, Bin Liu, Fei He, Shili Gai, Piaoping Yang, Dan Yang, Chunxia Li, Jun Lin. Recent advances on endogenous/exogenous stimuli-triggered nanoplatforms for enhanced chemodynamic therapy. Coordination Chemistry Reviews 2022, 451 , 214267. https://doi.org/10.1016/j.ccr.2021.214267
    85. Neha Suyog Potnis, Akbar Ali, Suchetan Pal. Recent Developments in ROS-Based Nanotherapeutic Modalities in Preclinical Cancer Treatment. 2022, 3059-3076. https://doi.org/10.1007/978-981-16-5422-0_261
    86. Noor Essa, Fiona O'Connell, Adriele Prina-Mello, Jacintha O'Sullivan, Simone Marcone. Gold nanoparticles and obese adipose tissue microenvironment in cancer treatment. Cancer Letters 2022, 525 , 1-8. https://doi.org/10.1016/j.canlet.2021.10.017
    87. Zhanjun Gu, Haili Yan, Long Gao, You Liao, Dongmei Wang, Duiping Feng, Jianguo Li, Jiangfeng Du, Hui Zhang. Hexagonal Na xWO 3 Nanocrystals with Reversible Valence States for Microwave Thermal and Chemodynamic Combined Cancer Therapy. SSRN Electronic Journal 2022, 300 https://doi.org/10.2139/ssrn.4053271
    88. Kun Chen, Yuan Liu, Mu Li, Lu Liu, Qiang Yu, Long Wu. Amelioration of enteric dysbiosis by polyoxotungstates in mice gut. Journal of Inorganic Biochemistry 2022, 226 , 111654. https://doi.org/10.1016/j.jinorgbio.2021.111654
    89. Yun Sun, Zhiguo Zhou, Shiping Yang, Hong Yang. Modulating hypoxia inducible factor‐1 by nanomaterials for effective cancer therapy. WIREs Nanomedicine and Nanobiotechnology 2022, 14 (1) https://doi.org/10.1002/wnan.1766
    90. Xiaoqing Sun, Zhenyu He, Ling Guo, Caiqin Wang, Chuyong Lin, Liping Ye, Xiaoqing Wang, Yue Li, Meisongzhu Yang, Sailan Liu, Xin Hua, Wen Wen, Chao Lin, Zhiqing Long, Wenwen Zhang, Han Li, Yunting Jian, Ziyuan Zhu, Xianqiu Wu, Huanxin Lin. ALG3 contributes to stemness and radioresistance through regulating glycosylation of TGF-β receptor II in breast cancer. Journal of Experimental & Clinical Cancer Research 2021, 40 (1) https://doi.org/10.1186/s13046-021-01932-8
    91. An Xie, He Li, Yumei Hao, Yujia Zhang. Tuning the Toxicity of Reactive Oxygen Species into Advanced Tumor Therapy. Nanoscale Research Letters 2021, 16 (1) https://doi.org/10.1186/s11671-021-03599-8
    92. Yunguang Zhang, Si Sun, Haile Liu, Qinjuan Ren, Wenting Hao, Qi Xin, Jiangang Xu, Hao Wang, Xiao-Dong Zhang. Catalytically active gold clusters with atomic precision for noninvasive early intervention of neurotrauma. Journal of Nanobiotechnology 2021, 19 (1) https://doi.org/10.1186/s12951-021-01071-4
    93. Yiming Ding, Yujie Dai, Mengqi Wu, Linlin Li. Glutathione-mediated nanomedicines for cancer diagnosis and therapy. Chemical Engineering Journal 2021, 426 , 128880. https://doi.org/10.1016/j.cej.2021.128880
    94. Zhongzhong Cao, Wen Yang, Xin Min, Jianhua Liu, Xiaohua Cao. Recent advances in synthesis and anti-tumor effect of organism-modified polyoxometalates inorganic organic hybrids. Inorganic Chemistry Communications 2021, 134 , 108904. https://doi.org/10.1016/j.inoche.2021.108904
    95. Liting Zheng, Rong Zhu, Lanlan Chen, Qinrui Fu, Jingying Li, Chen Chen, Jibin Song, Huanghao Yang. X-ray sensitive high-Z metal nanocrystals for cancer imaging and therapy. Nano Research 2021, 14 (11) , 3744-3755. https://doi.org/10.1007/s12274-021-3337-8
    96. Wei Liu, Bo Chen, Haocheng Zheng, Yun Xing, Guiyuan Chen, Peijie Zhou, Liting Qian, Yuanzeng Min. Advances of Nanomedicine in Radiotherapy. Pharmaceutics 2021, 13 (11) , 1757. https://doi.org/10.3390/pharmaceutics13111757
    97. Mengyao Chen, Chunyan Dong, Shuo Shi. Nanoparticle‐Mediated siRNA Delivery and Multifunctional Modification Strategies for Effective Cancer Therapy. Advanced Materials Technologies 2021, 6 (10) https://doi.org/10.1002/admt.202001236
    98. Xue Li, Jiang Li, Chunyin Li, Qi Guo, Menglin Wu, Lin Su, Yan Dou, Xinhong Wu, Zhaoxun Xiao, Xuening Zhang. Aminopeptidase N-targeting nanomolecule-assisted delivery of VEGF siRNA to potentiate antitumour therapy by suppressing tumour revascularization and enhancing radiation response. Journal of Materials Chemistry B 2021, 9 (36) , 7530-7543. https://doi.org/10.1039/D1TB00990G
    99. Jing Liu, Xixi Ai, Horacio Cabral, Jinlu Liu, Yuan Huang, Peng Mi. Tumor hypoxia-activated combinatorial nanomedicine triggers systemic antitumor immunity to effectively eradicate advanced breast cancer. Biomaterials 2021, 273 , 120847. https://doi.org/10.1016/j.biomaterials.2021.120847
    100. Sheng Wang, Rui Tian, Xu Zhang, Guohui Cheng, Peng Yu, Jin Chang, Xiaoyuan Chen. Beyond Photo: Xdynamic Therapies in Fighting Cancer. Advanced Materials 2021, 33 (25) https://doi.org/10.1002/adma.202007488
    Load all citations
    Download PDF

    Pair your accounts.

    Export articles to Mendeley

    Get article recommendations from ACS based on references in your Mendeley library.

    Pair your accounts.

    Export articles to Mendeley

    Get article recommendations from ACS based on references in your Mendeley library.

    You’ve supercharged your research process with ACS and Mendeley!

    STEP 1:
    Click to create an ACS ID

    Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

    Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

    Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

    MENDELEY PAIRING EXPIRED
    Your Mendeley pairing has expired. Please reconnect