Customizing Morphology, Size, and Response Kinetics of Matrix Metalloproteinase-Responsive Nanostructures by Systematic Peptide Design
- Jiye Son
Jiye SonAdvanced Science Research Center at The Graduate Center of the City University of New York, 85 Saint Nicholas Terrace, New York, New York 10031, United StatesDepartment of Chemistry, Brooklyn College, City University of New York, 2900 Bedford Avenue, Brooklyn, New York 11210, United StatesChemistryPh.D. Programs in , The Graduate Center of the City University of New York, 365 Fifth Avenue, New York, New York 10016, United StatesMore by Jiye Son
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- Daniela Kalafatovic
Daniela KalafatovicAdvanced Science Research Center at The Graduate Center of the City University of New York, 85 Saint Nicholas Terrace, New York, New York 10031, United StatesMore by Daniela Kalafatovic
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- Mohit Kumar
Mohit KumarAdvanced Science Research Center at The Graduate Center of the City University of New York, 85 Saint Nicholas Terrace, New York, New York 10031, United StatesMore by Mohit Kumar
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- Barney Yoo
Barney YooDepartment of Chemistry, Hunter College, City University of New York, 695 Park Avenue, New York, New York 10065, United StatesMore by Barney Yoo
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- Mike A. Cornejo
Mike A. CornejoDepartment of Chemistry, Brooklyn College, City University of New York, 2900 Bedford Avenue, Brooklyn, New York 11210, United StatesMore by Mike A. Cornejo
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- María Contel
María ContelDepartment of Chemistry, Brooklyn College, City University of New York, 2900 Bedford Avenue, Brooklyn, New York 11210, United StatesChemistry, Biochemistry and BiologyPh.D. Programs in , The Graduate Center of the City University of New York, 365 Fifth Avenue, New York, New York 10016, United StatesMore by María Contel
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- Rein V. Ulijn*
Rein V. Ulijn*E-mail: [email protected]Advanced Science Research Center at The Graduate Center of the City University of New York, 85 Saint Nicholas Terrace, New York, New York 10031, United StatesChemistryPh.D. Programs in , The Graduate Center of the City University of New York, 365 Fifth Avenue, New York, New York 10016, United StatesDepartment of Chemistry, Hunter College, City University of New York, 695 Park Avenue, New York, New York 10065, United StatesMore by Rein V. Ulijn
Abstract
Overexpression and activation of matrix metalloproteinase-9 (MMP-9) is associated with multiple diseases and can serve as a stimulus to activate nanomaterials for sensing and controlled release. In order to achieve autonomous therapeutics with improved space-time targeting capabilities, several features need to be considered beyond the introduction of an enzyme-cleavable linker into a nanostructure. We introduce guiding principles for a customizable platform using supramolecular peptide nanostructures with three modular components to achieve tunable kinetics and morphology changes upon MMP-9 exposure. This approach enables (1) fine-tuning of kinetics through introduction of ordered/disordered structures, (2) a 12-fold variation in hydrolysis rates achieved by electrostatic (mis)matching of particle and enzyme charge, and (3) selection of enzymatic reaction products that are either cell-killing nanofibers or disintegrate. These guiding principles, which can be rationalized and involve exchange of just a few amino acids, enable systematic customization of enzyme-responsive peptide nanostructures for general use in performance optimization of enzyme-responsive materials.
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