ACS Publications. Most Trusted. Most Cited. Most Read
My Activity
CONTENT TYPES

Graphene Biodevices for Early Disease Diagnosis Based on Biomarker Detection

  • Qingfang Han
    Qingfang Han
    Collaborative Innovation Center of Technology and Equipment for Biological Diagnosis and Therapy in Universities of Shandong, Institute for Advanced Interdisciplinary Research (iAIR), University of Jinan, Jinan 250022, Shandong, China
    School of Biological Science and Technology, University of Jinan, 336 West Road of Nan Xinzhuang, Jinan 250022, Shandong, China
    More by Qingfang Han
  • Jinbo Pang*
    Jinbo Pang
    Collaborative Innovation Center of Technology and Equipment for Biological Diagnosis and Therapy in Universities of Shandong, Institute for Advanced Interdisciplinary Research (iAIR), University of Jinan, Jinan 250022, Shandong, China
    *Email: [email protected]
    More by Jinbo Pang
  • Yufen Li
    Yufen Li
    Collaborative Innovation Center of Technology and Equipment for Biological Diagnosis and Therapy in Universities of Shandong, Institute for Advanced Interdisciplinary Research (iAIR), University of Jinan, Jinan 250022, Shandong, China
    More by Yufen Li
  • Baojun Sun
    Baojun Sun
    Collaborative Innovation Center of Technology and Equipment for Biological Diagnosis and Therapy in Universities of Shandong, Institute for Advanced Interdisciplinary Research (iAIR), University of Jinan, Jinan 250022, Shandong, China
    School of Biological Science and Technology, University of Jinan, 336 West Road of Nan Xinzhuang, Jinan 250022, Shandong, China
    More by Baojun Sun
  • Bergoi Ibarlucea
    Bergoi Ibarlucea
    Dresden Center for Computational Materials Science, Technische Universität Dresden, Dresden 01062, Germany
    Dresden Center for Intelligent Materials (GCL DCIM), Technische Universität Dresden, Dresden 01062, Germany
  • Xiaoyan Liu
    Xiaoyan Liu
    Collaborative Innovation Center of Technology and Equipment for Biological Diagnosis and Therapy in Universities of Shandong, Institute for Advanced Interdisciplinary Research (iAIR), University of Jinan, Jinan 250022, Shandong, China
    More by Xiaoyan Liu
  • Thomas Gemming
    Thomas Gemming
    Leibniz Institute for Solid State and Materials Research Dresden, Dresden D-01171, Germany
    More by Thomas Gemming
  • Qilin Cheng
    Qilin Cheng
    Collaborative Innovation Center of Technology and Equipment for Biological Diagnosis and Therapy in Universities of Shandong, Institute for Advanced Interdisciplinary Research (iAIR), University of Jinan, Jinan 250022, Shandong, China
    More by Qilin Cheng
  • Shu Zhang
    Shu Zhang
    Collaborative Innovation Center of Technology and Equipment for Biological Diagnosis and Therapy in Universities of Shandong, Institute for Advanced Interdisciplinary Research (iAIR), University of Jinan, Jinan 250022, Shandong, China
    More by Shu Zhang
  • Hong Liu*
    Hong Liu
    Collaborative Innovation Center of Technology and Equipment for Biological Diagnosis and Therapy in Universities of Shandong, Institute for Advanced Interdisciplinary Research (iAIR), University of Jinan, Jinan 250022, Shandong, China
    State Key Laboratory of Crystal Materials, Center of Bio & Micro/Nano Functional Materials, Shandong University, 27 Shandanan Road, Jinan 250100, China
    *Email: [email protected]
    More by Hong Liu
  • Jingang Wang
    Jingang Wang
    Collaborative Innovation Center of Technology and Equipment for Biological Diagnosis and Therapy in Universities of Shandong, Institute for Advanced Interdisciplinary Research (iAIR), University of Jinan, Jinan 250022, Shandong, China
    More by Jingang Wang
  • Weijia Zhou
    Weijia Zhou
    Collaborative Innovation Center of Technology and Equipment for Biological Diagnosis and Therapy in Universities of Shandong, Institute for Advanced Interdisciplinary Research (iAIR), University of Jinan, Jinan 250022, Shandong, China
    More by Weijia Zhou
  • Gianaurelio Cuniberti*
    Gianaurelio Cuniberti
    Dresden Center for Computational Materials Science, Technische Universität Dresden, Dresden 01062, Germany
    Dresden Center for Intelligent Materials (GCL DCIM), Technische Universität Dresden, Dresden 01062, Germany
    Institute for Materials Science and Max Bergmann Center of Biomaterials, Technische Universität Dresden, Dresden 01069, Germany
    Center for Advancing Electronics Dresden, Technische Universität Dresden, Dresden 01069, Germany
    *Email: [email protected]
  • , and 
  • Mark H. Rümmeli*
    Mark H. Rümmeli
    Leibniz Institute for Solid State and Materials Research Dresden, Dresden D-01171, Germany
    College of Energy, Soochow, Institute for Energy and Materials Innovations, Soochow University, Suzhou 215006, China
    Key Laboratory of Advanced Carbon Materials and Wearable Energy Technologies of Jiangsu Province, Soochow University, Suzhou 215006, China
    Centre of Polymer and Carbon Materials, Polish Academy of Sciences, M. Curie Sklodowskiej 34, Zabrze 41-819, Poland
    Institute of Environmental Technology (CEET), VŠB-Technical University of Ostrava, 17. Listopadu 15, Ostrava 708 33, Czech Republic
    *Email: [email protected]
Cite this: ACS Sens. 2021, 6, 11, 3841–3881
Publication Date (Web):October 25, 2021
https://doi.org/10.1021/acssensors.1c01172
Copyright © 2021 American Chemical Society

    Article Views

    4101

    Altmetric

    -

    Citations

    29
    LEARN ABOUT THESE METRICS
    Other access options

    Abstract

    Abstract Image

    The early diagnosis of diseases plays a vital role in healthcare and the extension of human life. Graphene-based biosensors have boosted the early diagnosis of diseases by detecting and monitoring related biomarkers, providing a better understanding of various physiological and pathological processes. They have generated tremendous interest, made significant advances, and offered promising application prospects. In this paper, we discuss the background of graphene and biosensors, including the properties and functionalization of graphene and biosensors. Second, the significant technologies adopted by biosensors are discussed, such as field-effect transistors and electrochemical and optical methods. Subsequently, we highlight biosensors for detecting various biomarkers, including ions, small molecules, macromolecules, viruses, bacteria, and living human cells. Finally, the opportunities and challenges of graphene-based biosensors and related broad research interests are discussed.

    Read this article

    To access this article, please review the available access options below.

    Get instant access

    Purchase Access

    Read this article for 48 hours. Check out below using your ACS ID or as a guest.

    Recommended

    Access through Your Institution

    You may have access to this article through your institution.

    Your institution does not have access to this content. You can change your affiliated institution below.

    Cited By

    This article is cited by 29 publications.

    1. Rodrigo G. Ferreira, Abílio P. Silva, João Nunes-Pereira. Current On-Skin Flexible Sensors, Materials, Manufacturing Approaches, and Study Trends for Health Monitoring: A Review. ACS Sensors 2024, 9 (3) , 1104-1133. https://doi.org/10.1021/acssensors.3c02555
    2. Yuechun Li, Zhaowen Cui, Longhua Shi, Jinrui Shan, Wentao Zhang, Yanru Wang, Yanwei Ji, Daohong Zhang, Jianlong Wang. Perovskite Nanocrystals: Superior Luminogens for Food Quality Detection Analysis. Journal of Agricultural and Food Chemistry 2024, 72 (9) , 4493-4517. https://doi.org/10.1021/acs.jafc.3c06660
    3. Nathália M. Galdino, Virgínia S. Souza, Fabiano S. Rodembusch, Roberta Bussamara, Jackson D. Scholten. Biosensors Based on Graphene Oxide Functionalized with Benzothiadiazole-Derived Ligands for the Detection of Cholesterol. ACS Applied Bio Materials 2023, 6 (7) , 2651-2666. https://doi.org/10.1021/acsabm.2c01054
    4. Celia Ferrag, Meissam Noroozifar, Kagan Kerman. Ultralight 3D Graphene Oxide Aerogel Decorated with Pd–Fe Nanoparticles for the Simultaneous Detection of Eight Biomolecules. ACS Applied Materials & Interfaces 2023, 15 (23) , 27502-27514. https://doi.org/10.1021/acsami.3c01600
    5. Xin Xi, Wei Tang, Dongqing Wu, Chaochao Shen, Wei Ji, Jun Li, Yuezeng Su, Xiaojun Guo, Ruili Liu, Feng Yan. All-Carbon Solution-Gated Transistor with Low Operating Voltages for Highly Selective and Stable Dopamine Sensing. ACS Sensors 2023, 8 (3) , 1211-1219. https://doi.org/10.1021/acssensors.2c02608
    6. Young-Jae Jin, Beom-Min Si, Eonji Kim, Jineun Lee, Heesang Kim, Giseop Kwak, Toshikazu Sakaguchi, Jinhee Lee, In Young Song, Chang-Lyoul Lee, Joon Heon Kim, Kyuyoung Heo, Wang-Eun Lee. Reusable, Ultrasensitive, Patterned Conjugated Polyelectrolyte–Surfactant Complex Film with a Wide Detection Range for Copper Ion Detection. ACS Applied Materials & Interfaces 2023, 15 (9) , 12339-12349. https://doi.org/10.1021/acsami.2c21388
    7. Jinbo Pang, Songang Peng, Chongyang Hou, Hongbin Zhao, Yingju Fan, Chen Ye, Nuo Zhang, Ting Wang, Yu Cao, Weijia Zhou, Ding Sun, Kai Wang, Mark H. Rümmeli, Hong Liu, Gianaurelio Cuniberti. Applications of Graphene in Five Senses, Nervous System, and Artificial Muscles. ACS Sensors 2023, 8 (2) , 482-514. https://doi.org/10.1021/acssensors.2c02790
    8. Katherine A. Mirica (Associate Editor, Dartmouth College). Materials Matter: Advancing Sensor Science through Innovation in Materials Chemistry. ACS Sensors 2022, 7 (12) , 3580-3581. https://doi.org/10.1021/acssensors.2c02675
    9. Deepshikha Shahdeo, Neha Chauhan, Aniket Majumdar, Arindam Ghosh, Sonu Gandhi. Graphene-Based Field-Effect Transistor for Ultrasensitive Immunosensing of SARS-CoV-2 Spike S1 Antigen. ACS Applied Bio Materials 2022, 5 (7) , 3563-3572. https://doi.org/10.1021/acsabm.2c00503
    10. Kugalur Shanmugam Ranjith, Seyed Majid Ghoreishian, Bumjun Park, Hoomin Lee, Nilesh R. Chodankar, Ganji Seeta Rama Raju, Yun Suk Huh, Young-Kyu Han. Fluorescence light-up electrospun membrane incorporated with perovskite nanoclusters as a highly sensitive colorimetric probe for detection of amine vapors during food spoilage. Sensors and Actuators B: Chemical 2023, 384 , 133622. https://doi.org/10.1016/j.snb.2023.133622
    11. Zakir Ullah, Hyun Jee Kim, Y. Sheena Mary, Nasser Belboukhari, Khaled Sekkoum, Aicha Kraimi, Xuan Zhan, Hyung Wook Kwon. Unlocking the potential of ovalene: A dual-purpose sensor and drug enhancer. Journal of Molecular Liquids 2023, 377 , 121540. https://doi.org/10.1016/j.molliq.2023.121540
    12. Yanxin Li, Shuju Zhao, Zhenying Xu, Xiujuan Qiao, Mingxuan Li, Youke Li, Xiliang Luo. Peptide nucleic acid and antifouling peptide based biosensor for the non-fouling detection of COVID-19 nucleic acid in saliva. Biosensors and Bioelectronics 2023, 225 , 115101. https://doi.org/10.1016/j.bios.2023.115101
    13. Ali Mohammadpour-Haratbar, Seyyed Behnam Abdollahi Boraei, Yasser Zare, Kyong Yop Rhee, Soo-Jin Park. Graphene-Based Electrochemical Biosensors for Breast Cancer Detection. Biosensors 2023, 13 (1) , 80. https://doi.org/10.3390/bios13010080
    14. Ilham Alkian, Heri Sutanto, B Hadiyanto, Adi Prasetio, Bella Aprimanti Utami, . Facile synthesized carbon dots for simple and selective detection of cobalt ions in aqueous media. Cogent Engineering 2022, 9 (1) https://doi.org/10.1080/23311916.2022.2033467
    15. Yufen Li, Shirong Huang, Songang Peng, Hao Jia, Jinbo Pang, Bergoi Ibarlucea, Chongyang Hou, Yu Cao, Weijia Zhou, Hong Liu, Gianaurelio Cuniberti. Toward Smart Sensing by MXene. Small 2022, 33 , 2206126. https://doi.org/10.1002/smll.202206126
    16. Rahul Shankar Tade, Pravin Onkar Patil. Fabrication of poly (aspartic) acid functionalized graphene quantum dots based FRET sensor for selective and sensitive detection of MAGE-A11 antigen. Microchemical Journal 2022, 183 , 107971. https://doi.org/10.1016/j.microc.2022.107971
    17. Jinbo Pang, Songang Peng, Chongyang Hou, Xiao Wang, Ting Wang, Yu Cao, Weijia Zhou, Ding Sun, Kai Wang, Mark H. Rümmeli, Gianaurelio Cuniberti, Hong Liu. Applications of MXenes in human-like sensors and actuators. Nano Research 2022, 577 https://doi.org/10.1007/s12274-022-5272-8
    18. Yuhuan Zhang, Chun Xian Guo, Hongfang Du, Xingyu Wang, Liu Liu, Chang Ming Li. Solvent-engineered morphologies of Mn-MOF toward ultrasensitive sensing cell superoxide. Electrochimica Acta 2022, 431 , 141147. https://doi.org/10.1016/j.electacta.2022.141147
    19. Jianhui Xiong, Yuxi Yang, Linyu Wang, Shouhui Chen, Yan Du, Yonghai Song. Electrochemical Sensors Based on Metal-Porous Carbon Nanozymes for Dopamine, Uric Acid and Furazolidone. Chemosensors 2022, 10 (11) , 458. https://doi.org/10.3390/chemosensors10110458
    20. Yu Cao, Chaoying Liu, Tinghe Yang, Yao Zhao, Yanling Na, Chongxv Jiang, Jing Zhou, Jinbo Pang, Hong Liu, Mark H. Rummeli, Weijia Zhou, Gianaurelio Cuniberti. Gradient bandgap modification for highly efficient carrier transport in antimony sulfide-selenide tandem solar cells. Solar Energy Materials and Solar Cells 2022, 246 , 111926. https://doi.org/10.1016/j.solmat.2022.111926
    21. Ayoub Shiravandi, Farzaneh Yari, Nahid Tofigh, Mohammad Kazemi Ashtiani, Koorosh Shahpasand, Mohammad-Hossein Ghanian, Faezeh Shekari, Farnoush Faridbod. Earlier Detection of Alzheimer’s Disease Based on a Novel Biomarker cis P-tau by a Label-Free Electrochemical Immunosensor. Biosensors 2022, 12 (10) , 879. https://doi.org/10.3390/bios12100879
    22. Shahriar Mostufa, Tarik Bin Abdul Akib, Md. Masud Rana, Md. Rabiul Islam. Highly Sensitive TiO2/Au/Graphene Layer-Based Surface Plasmon Resonance Biosensor for Cancer Detection. Biosensors 2022, 12 (8) , 603. https://doi.org/10.3390/bios12080603
    23. Vladyslav Mishyn, Merve Aslan, Adrien Hugo, Teresa Rodrigues, Henri Happy, Rana Sanyal, Wolfgang Knoll, Florence Baudoux, Vincent Bouchiat, Rostyslav O. Bilyy, Rabah Boukherroub, Amitav Sanyal, Sabine Szunerits. Catch and release strategy of matrix metalloprotease aptamers via thiol–disulfide exchange reaction on a graphene based electrochemical sensor. Sensors & Diagnostics 2022, 1 (4) , 739-749. https://doi.org/10.1039/D2SD00070A
    24. Vivek Chaudhary, P Neugebauer, O Mounkachi, S Lahbabi, A El Fatimy. Phosphorene—an emerging two-dimensional material: recent advances in synthesis, functionalization, and applications. 2D Materials 2022, 9 (3) , 032001. https://doi.org/10.1088/2053-1583/ac6dc2
    25. Bruno Gil, Salzitsa Anastasova, Benny Lo. Graphene field-effect transistors array for detection of liquid conductivities in the physiological range through novel time-multiplexed impedance measurements. Carbon 2022, 193 , 394-403. https://doi.org/10.1016/j.carbon.2022.03.050
    26. Mir Waqas Alam, Jawayria Najeeb, Sumaira Naeem, Sheikh Muhammad Usman, Insha Nahvi, Fai Alismail, Alaaedeen Abuzir, Mohd Farhan, Allah Nawaz. Electrochemical Methodologies for Investigating the Antioxidant Potential of Plant and Fruit Extracts: A Review. Antioxidants 2022, 11 (6) , 1205. https://doi.org/10.3390/antiox11061205
    27. Rijo Rajeev, Ditto Abraham Thadathil, Anitha Varghese. New horizons in surface topography modulation of MXenes for electrochemical sensing toward potential biomarkers of chronic disorders. Critical Reviews in Solid State and Materials Sciences 2022, 30 , 1-43. https://doi.org/10.1080/10408436.2022.2078789
    28. Qing Zhang, Shangshang Ma, Xin Zhuo, Cong Wang, Hongyan Wang, Yuying Xing, Qingyuan Xue, Keying Zhang. An ultrasensitive electrochemical sensing platform based on silver nanoparticle-anchored 3D reduced graphene oxide for rifampicin detection. The Analyst 2022, 147 (10) , 2156-2163. https://doi.org/10.1039/D2AN00452F
    29. Petr Rozhin, Jada Abdel Monem Gamal, Silvia Giordani, Silvia Marchesan. Carbon Nanomaterials (CNMs) and Enzymes: From Nanozymes to CNM-Enzyme Conjugates and Biodegradation. Materials 2022, 15 (3) , 1037. https://doi.org/10.3390/ma15031037

    Pair your accounts.

    Export articles to Mendeley

    Get article recommendations from ACS based on references in your Mendeley library.

    Pair your accounts.

    Export articles to Mendeley

    Get article recommendations from ACS based on references in your Mendeley library.

    You’ve supercharged your research process with ACS and Mendeley!

    STEP 1:
    Click to create an ACS ID

    Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

    Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

    Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

    MENDELEY PAIRING EXPIRED
    Your Mendeley pairing has expired. Please reconnect