Early-Life Blockade of the 5-HT Transporter Alters Emotional Behavior in Adult Mice
Abstract
Reduced serotonin transporter (5-HTT) expression is associated with abnormal affective and anxiety-like symptoms in humans and rodents, but the mechanism of this effect is unknown. Transient inhibition of 5-HTT during early development with fluoxetine, a commonly used serotonin selective reuptake inhibitor, produced abnormal emotional behaviors in adult mice. This effect mimicked the behavioral phenotype of mice genetically deficient in 5-HTT expression. These findings indicate a critical role of serotonin in the maturation of brain systems that modulate emotional function in the adult and suggest a developmental mechanism to explain how low-expressing 5-HTT promoter alleles increase vulnerability to psychiatric disorders.
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We acknowledge the generous gift of fluoxetine from E. Lilly, the analytical work of T. Cooper, and the helpful comments of F. Menzaghi, J. Gordon, M. Myers, and C. Gross.
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Science
Volume 306 | Issue 5697
29 October 2004
29 October 2004
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American Association for the Advancement of Science.
Submission history
Received: 18 June 2004
Accepted: 26 August 2004
Published in print: 29 October 2004
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