Mitochondrial targeting sequences may form amphiphilic helices.
The EMBO Journal
(1986)
5: 1335 - 1342
Twenty three mitochondrial targeting sequences have been analysed with regard to their potential for forming amphiphilic helices. It is shown that most if not all of these sequences can be expected to form helices with high hydrophobic moments in a suitable environment. In the few cases studied so far, the segments of maximal hydrophobic moment coincide closely with ‘critical’ regions defined by deletions and point mutations.
Formats available
You can view the full content in the following formats:
Information & Authors
Information
Published In
Submission history
Published online: 1 June 1986
Published in issue: June 1986
Copyright
© 1986 European Molecular Biology Organization.
Authors
Metrics & Citations
Metrics
Citations
Download Citations
If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Select your manager software from the list below and click Download.
Citing Literature
- Yury S Bykov, Tamara Flohr, Felix Boos, Naama Zung, Johannes M Herrmann, Maya Schuldiner, Widespread use of unconventional targeting signals in mitochondrial ribosome proteins, The EMBO Journal, 10.15252/embj.2021109519, 41, 1, (2022).
- Jingjing Zhang, Qian Wang, Mingsong Wang, Manxi Jiang, Yongsheng Wang, Yun Sun, Junpeng Wang, Taorong Xie, Chao Tang, Nannan Tang, Huili Song, Di Cui, Ruihua Chao, Shuzhe Ding, Bing Ni, Xuejin Chen, Yuan Wang, GASZ and mitofusin‐mediated mitochondrial functions are crucial for spermatogenesis, EMBO reports, 10.15252/embr.201540846, 17, 2, (220-234), (2015).
- Takashi Saitoh, Mayumi Igura, Takayuki Obita, Toyoyuki Ose, Rieko Kojima, Katsumi Maenaka, Toshiya Endo, Daisuke Kohda, Tom20 recognizes mitochondrial presequences through dynamic equilibrium among multiple bound states, The EMBO Journal, 10.1038/sj.emboj.7601888, 26, 22, (4777-4787), (2007).
- Tincuta Stan, Uwe Ahting, Markus Dembowski, Klaus‐Peter Künkele, Stephan Nussberger, Walter Neupert, Doron Rapaport, Recognition of preproteins by the isolated TOM complex of mitochondria, The EMBO Journal, 10.1093/emboj/19.18.4895, 19, 18, (4895-4902), (2000).
- Heike Fölsch, Brigitte Gaume, Michael Brunner, Walter Neupert, Rosemary A. Stuart, C‐ to N‐terminal translocation of preproteins into mitochondria, The EMBO Journal, 10.1093/emboj/17.22.6508, 17, 22, (6508-6515), (1998).
- Fabrice Rébeillé, David Macherel, Jean‐Marie Mouillon, Jérome Garin, Roland Douce, Folate biosynthesis in higher plants: purification and molecular cloning of a bifunctional 6‐hydroxymethyl‐7,8‐dihydropterin pyrophosphokinase/7,8‐dihydropteroate synthase localized in mitochondria, The EMBO Journal, 10.1093/emboj/16.5.947, 16, 5, (947-957), (1997).
- Peter J. Bradley, Carol J. Lahti, Evelyn Plümper, Patricia J. Johnson, Targeting and translocation of proteins into the hydrogenosome of the protist Trichomonas: similarities with mitochondrial protein import, The EMBO Journal, 10.1093/emboj/16.12.3484, 16, 12, (3484-3493), (1997).