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Elicitation of Pharmacologically Active Substances in an Intact Medical Plant

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† Department of Agroecology, Faculty of Agriculture, University of South Bohemia, Studentska 13, 370 05 Ceske Budejovice, Czech Republic
‡ Institute of System Biology and Ecology, Academy of Sciences of the Czech Republic, v.v.i., Branisovska 31, 370 05 Ceske Budejovice, Czech Republic
§ Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, v.v.i., Heyrovsky Sq. 2, 162 06 Prague 6, Czech Republic
*Address correspondence to this author at The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 [telephone (858) 784-2091; fax (858) 784-2139; e-mail [email protected]].
Cite this: J. Agric. Food Chem. 2009, 57, 17, 7907–7911
Publication Date (Web):August 7, 2009
https://doi.org/10.1021/jf9011246
Copyright © 2009 American Chemical Society
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    The quality of medical plants used for the production of galenics or pharmacologically useful compounds is usually assessed by the content of biologically active compounds. Because most of these plants are grown in fields, this study focused on stimulation of active compounds by in vivo elicitation. Foliar application of elicitors on the immunostimulating medical plant purple coneflower (Echinacea purpurea L. Moench.) grown on soil was used to increase the content of biologically active phenolics. Natural plant stress mediators and their derivatives (acetylsalicylic acid, salicylic acid, and methyl salicylate) as well as newly introduced biocompatible metal elicitor [titanium(IV) ascorbate] were chosen as active components of foliar sprays. A tremendous increase of phenolics (up to 10 times compared to control) and stimulation of the biomass yield were achieved. Tuning of organ specificity by modulation of the concentration of elicitor was also observed. This methodology represents a convenient alternative to cell suspension or hydroponic cultures being applicable in wide agricultural practice.

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