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First published July 2001

Elevated Systemic Concentrations of Soluble ICAM-1 (sICAM) are Not Reflected in the Gingival Crevicular Fluid of Smokers with Periodontitis

H.S. Fraser, R.M. Palmer, R.F. Wilson, P.Y. Coward, and D.A. ScottView all authors and affiliations
Volume 80, Issue 7
https://doi.org/10.1177/00220345010800070901

Abstract

Raised serum levels of soluble intercellular adhesion molecule-1 (sICAM-1) in smokers could have immunomodulatory effects in periodontitis. The aim of this study was to compare serum and gingival crevicular fluid (GCF) concentrations of sICAM-1 in smokers and non-smokers with periodontal disease. sICAM-1 in serum and GCF collected from age- and gender-matched smokers (n = 14) and non-smokers (n = 14) with periodontitis were measured by ELISA. Mean serum sICAM-1 concentrations were significantly elevated in smokers (331 ng mL-1), compared with non-smokers (238 ng mL-1, p = 0.008). However, the concentration of sICAM-1 in the GCF was significantly lower in the smokers (83 ng mL -1), compared with non-smokers (212 ng mL-1, p = 0.013). The difference between concentrations of sICAM-1 in GCF and serum was significant only in smokers (p < 0.001). Since GCF is a serum-derived tissue exudate, these results suggest that, in smokers, circulating sICAM-1 molecules are affected either in their passage from the periodontal microvasculature or within the periodontal tissues.

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Published In

Volume 80, Issue 7
Pages: 1643 - 1647
Article first published: July 2001
Issue published: July 2001

Keywords

  1. cotinine
  2. human
  3. periodontitis
  4. soluble ICAM-1
  5. smoking.

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PubMed: 11597025

Authors

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H.S. Fraser
Departments of Periodontology and Preventive Dentistry
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R.M. Palmer
Departments of Periodontology and Preventive Dentistry, [email protected]
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R.F. Wilson
Dental Clinical Research, Guy's, King's, and St. Thomas' Dental Institute, Schools of Medicine and Dentistry, Floor 21, Guy's Hospital Tower, King's College London, London, SE1 9RT, UK
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P.Y. Coward
Dental Clinical Research, Guy's, King's, and St. Thomas' Dental Institute, Schools of Medicine and Dentistry, Floor 21, Guy's Hospital Tower, King's College London, London, SE1 9RT, UK
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D.A. Scott
Dental Clinical Research, Guy's, King's, and St. Thomas' Dental Institute, Schools of Medicine and Dentistry, Floor 21, Guy's Hospital Tower, King's College London, London, SE1 9RT, UK
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