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First published online October 5, 2012

Cannabidiol inhibits THC-elicited paranoid symptoms and hippocampal-dependent memory impairment

Amir Englund, Paul D Morrison, Judith Nottage, Dominic Hague, Fergus Kane, Stefania Bonaccorso, James M Stone, Avi Reichenberg, Rudolf Brenneisen, David Holt, Amanda Feilding, Lucy Walker, Robin M Murray, and Shitij KapurView all authors and affiliations
Volume 27, Issue 1
https://doi.org/10.1177/0269881112460109

Abstract

Community-based studies suggest that cannabis products that are high in Δ9-tetrahydrocannabinol (THC) but low in cannabidiol (CBD) are particularly hazardous for mental health. Laboratory-based studies are ideal for clarifying this issue because THC and CBD can be administered in pure form, under controlled conditions. In a between-subjects design, we tested the hypothesis that pre-treatment with CBD inhibited THC-elicited psychosis and cognitive impairment. Healthy participants were randomised to receive oral CBD 600mg (n=22) or placebo (n=26), 210 min ahead of intravenous (IV) THC (1.5 mg). Post-THC, there were lower PANSS positive scores in the CBD group, but this did not reach statistical significance. However, clinically significant positive psychotic symptoms (defined a priori as increases ≥3 points) were less likely in the CBD group compared with the placebo group, odds ratio (OR)=0.22 (χ2=4.74, p<0.05). In agreement, post-THC paranoia, as rated with the State Social Paranoia Scale (SSPS), was less in the CBD group compared with the placebo group (t=2.28, p<0.05). Episodic memory, indexed by scores on the Hopkins Verbal Learning Task-revised (HVLT-R), was poorer, relative to baseline, in the placebo pre-treated group (-10.6±18.9%) compared with the CBD group (-0.4%±9.7 %) (t=2.39, p<0.05). These findings support the idea that high-THC/low-CBD cannabis products are associated with increased risks for mental health.

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Published In

Volume 27, Issue 1
Pages: 19 - 27
Article first published online: October 5, 2012
Issue published: January 2013

Keywords

  1. Delta-9-tetrahydrocannabinol
  2. cannabidiol
  3. THC
  4. CBD
  5. psychosis

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© The Author(s) 2013.
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PubMed: 23042808

Authors

Affiliations

Amir Englund
The Biomedical Research Centre, Institute of Psychiatry, King’s College London, London, UK
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Paul D Morrison
The Biomedical Research Centre, Institute of Psychiatry, King’s College London, London, UK
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Judith Nottage
The Biomedical Research Centre, Institute of Psychiatry, King’s College London, London, UK
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Dominic Hague
The Biomedical Research Centre, Institute of Psychiatry, King’s College London, London, UK
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Fergus Kane
The Biomedical Research Centre, Institute of Psychiatry, King’s College London, London, UK
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Stefania Bonaccorso
The Biomedical Research Centre, Institute of Psychiatry, King’s College London, London, UK
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James M Stone
Department of Experimental Medicine, Imperial College London, London, UK
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Avi Reichenberg
The Biomedical Research Centre, Institute of Psychiatry, King’s College London, London, UK
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Rudolf Brenneisen
Department of Clinical Research, University of Bern, Bern, Switzerland
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David Holt
Division of Clinical Sciences, The Analytic Unit, St George’s, University of London, London, UK
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Amanda Feilding
The Beckley Foundation, Oxford, UK
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Lucy Walker
The Biomedical Research Centre, Institute of Psychiatry, King’s College London, London, UK
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Robin M Murray
The Biomedical Research Centre, Institute of Psychiatry, King’s College London, London, UK
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Shitij Kapur
The Biomedical Research Centre, Institute of Psychiatry, King’s College London, London, UK
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Notes

Paul D Morrison, The Biomedical Research Centre, Institute of Psychiatry, King’s College London, De Crespigny Park, Denmark Hill, London, SE5 8AF, UK. Email: [email protected]

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