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Uptake and Accumulation of Polystyrene Microplastics in Zebrafish (Danio rerio) and Toxic Effects in Liver

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† State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, Jiangsu 210023, China
‡ Jiangsu Key Lab Environmental Change & Ecological Construct, School of Geography Science, Nanjing Normal University, Nanjing, Jiangsu 210023, China
*Phone: +86 25 89680160; e-mail: [email protected] (Yan Zhang).
*E-mail: [email protected] (Hongqiang Ren).
Cite this: Environ. Sci. Technol. 2016, 50, 7, 4054–4060
Publication Date (Web):March 7, 2016
https://doi.org/10.1021/acs.est.6b00183
Copyright © 2016 American Chemical Society
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    Abstract

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    Microplastics have become emerging contaminants, causing widespread concern about their potential toxic effects. In this study, the uptake and tissue accumulation of polystyrene microplastics (PS-MPs) in zebrafish were detected, and the toxic effects in liver were investigated. The results showed that after 7 days of exposure, 5 μm diameter MPs accumulated in fish gills, liver, and gut, while 20 μm diameter MPs accumulated only in fish gills and gut. Histopathological analysis showed that both 5 μm and 70 nm PS-MPs caused inflammation and lipid accumulation in fish liver. PS-MPs also induced significantly increased activities of superoxide dismutase and catalase, indicating that oxidative stress was induced after treatment with MPs. In addition, metabolomic analysis suggested that exposure to MPs induced alterations of metabolic profiles in fish liver and disturbed the lipid and energy metabolism. These findings provide new insights into the toxic effects of MPs on fish.

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