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Nanoplastic-Induced Genotoxicity and Intestinal Damage in Freshwater Benthic Clams (Corbicula fluminea): Comparison with Microplastics

  • Zhenling Li
    Zhenling Li
    State Key Laboratory of Water Environment Simulation, School of Environment, Beijing Normal University, Beijing 100875, P.R. China
    More by Zhenling Li
  • , 
  • Chenghong Feng*
    Chenghong Feng
    State Key Laboratory of Water Environment Simulation, School of Environment, Beijing Normal University, Beijing 100875, P.R. China
    The Key Laboratory of Water and Sediment Sciences, Ministry of Education, School of Environment, Beijing Normal University, Beijing 100875, P.R. China
    *Tel: +86 10 58804573. Email: [email protected]
    More by Chenghong Feng
    Orcidhttps://orcid.org/0000-0002-2130-8851
  • , 
  • Wen Pang
    Wen Pang
    State Key Laboratory of Water Environment Simulation, School of Environment, Beijing Normal University, Beijing 100875, P.R. China
    More by Wen Pang
  • , 
  • Chenhao Tian
    Chenhao Tian
    The Key Laboratory of Water and Sediment Sciences, Ministry of Education, School of Environment, Beijing Normal University, Beijing 100875, P.R. China
    More by Chenhao Tian
  • , and 
  • Yue Zhao
    Yue Zhao
    The Key Laboratory of Water and Sediment Sciences, Ministry of Education, School of Environment, Beijing Normal University, Beijing 100875, P.R. China
    More by Yue Zhao
Cite this: ACS Nano 2021, 15, 6, 9469–9481
Publication Date (Web):May 14, 2021
https://doi.org/10.1021/acsnano.1c02407
Copyright © 2021 American Chemical Society
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    Abstract

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    With the wide application of plastics in daily life, nanoplastics (NPs) are ubiquitous in freshwater environments. However, to date, few studies have focused on the mechanism underlying the toxicity of NPs, and the differences between this mechanism and that governing the toxicity of MPs have also not been thoroughly characterized. In this study, the genotoxicity, intestinal damage, and intestinal flora in Corbicula fluminea exposed to micro/nanoplastics were investigated through RNA sequencing, histopathology, and 16S rRNA sequencing, respectively. Significant differences in differentially expressed genes (DEGs) were observed between MP and NP exposure groups. It was observed that NPs preferentially elicited the process related to cellular components and triggered the apoptosis through the mitochondrial pathway in various tissues, especially in indirectly contacted tissues, while MPs induced the innate immune response and activated the complement and coagulation cascades (complement system) pathway. Both MPs and NPs can induce an inflammatory response and cause epithelial damage in the intestines, and they can notably change the gut microbial community structure. However, the abundance of pathogenic bacteria (e.g., Mycoplasma) was observed to increase only in the MP-treated group, which exacerbated intestinal damage. Unlike MPs, the effect of NPs on the intestinal microflora was highly limited, while NPs elicited more severe damage to the intestinal mucosal barrier. The results of this study may help to elucidate the toxicity mechanisms governing the responses of bivalves to MPs and NPs and to evaluate the detriment of MPs and NPs to the benthic ecosystem.

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    The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acsnano.1c02407.

    • Venn diagram (Figure S1), network analysis (Figure S2), immunohistochemistry (Figure S3), activity changes (Figure S4), characterization of MPs and NPs (Figure S5), standard curve (Figure S6) (PDF)

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