This cohort study uses pooled data from 3 randomized clinical trials to assess the association between physical activity levels before the COVID-19 pandemic and subsequent odds of COVID-19 diagnosis and hospitalization.

This cohort study examines the metabolism of and response to vitamin D supplementation in individuals by levels of vitamin D–related serum biomarkers in association with adiposity.

This study assesses whether vitamin D supplementation prevents statin-associated muscle symptoms and reduces statin discontinuation.

This ancillary study of a randomized clinical trial investigates the effects of vitamin D3 with omega-3 fatty acid supplementation on frailty in older adults.

This randomized clinical trial evaluates the impact of daily ω-3 supplementation on the development of incident dry eye disease.

This randomized clinical trial tested the effects of daily omega-3 supplementation vs placebo on depression prevention in older adults without depression.

This 2 × 2 factorial trial compares the effects of omega-3 fatty acids (460 mg/d of EPA and 380 mg/d of DHA) vs placebo, vitamin D₃ vs placebo, both, or neither on risk of incident atrial fibrillation (AF) among adults aged 50 years or older over a median of more than 5 years of treatment.

This secondary analysis of a randomized clinical trial evaluates the effect vitamin D on the incidence of advanced (metastatic or fatal) cancer among adults without cancer at baseline and examines possible effect modification by body mass index.

This prespecified ancillary analysis of the VITAL (Vitamin D and Omega-3 Trial) nationwide randomized clinical trial assesses whether daily supplementation for approximately 4 to 6 years with vitamin D₃, marine ω-3 fatty acids, or both vs placebo prevents the development or progression of age-related macular degeneration in initially healthy US adults.

This randomized clinical trial compares the effects of vitamin D₃ supplementation vs placebo on depression risk and mood scores in men and women aged 50 years or older.

This cohort study uses Women’s Health Study data to compare the association of migraine with aura vs other major vascular risk factors (diabetes, hypertension, dyslipidemia, smoking, BMI, CVD family history) with incidence of cardiovascular disease.

This 2 × 2 factorial trial compares the effects of vitamin D₃ vs placebo and omega-3 fatty acids vs placebo on change in glomerular filtration rate estimated from serum creatinine and cystatin C (eGFR) over 5 years in adults with type 2 diabetes.

This prespecified ancillary study of a randomized clinical trial compares the effects of daily marine ω-3 fatty acid supplementation vs placebo on risk of colorectal cancer precursors, including conventional adenomas and serrated polyps, in an average-risk US population.

This cohort study of 16 741 older women from the Women’s Health Study examines associations of number of steps per day and stepping intensity with all-cause mortality.

This secondary analysis of the Physicians’ Health Study II randomized clinical trial investigates effect modification by various baseline dietary factors on cardiovascular disease risk.

This study uses data from the Breast and Prostate Cancer Cohort Consortium and the National Health Interview Survey to develop a model predicting the absolute risk of breast cancer for white women in the United States.

This large, long-term prospective cohort study evaluates the associations between atrial fibrillation and cancer.