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JAMA Network Open Original Investigation Public Health
February 13, 2024
Dennis Muñoz-Vergara, DVM, MPH; Peter M. Wayne, PhD; Eunjung Kim, MS; I-Min Lee, MBBS, ScD; Julie E. Buring, ScD; JoAnn E. Manson, MD, DrPH; Howard D. Sesso, ScD, MPH
open access
JAMA Netw Open. 2024; 7(2):e2355808. 10.1001/jamanetworkopen.2023.55808
This cohort study uses pooled data from 3 randomized clinical trials to assess the association between physical activity levels before the COVID-19 pandemic and subsequent odds of COVID-19 diagnosis and hospitalization.
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JAMA Network Open Original Investigation Nutrition, Obesity, and Exercise
January 17, 2023
Deirdre K. Tobias, ScD; Heike Luttmann-Gibson, PhD; Samia Mora, MD, MHS; Jacqueline Danik, MD, DrPH; Vadim Bubes, PhD; Trisha Copeland, MS, RD; Meryl S. LeBoff, MD; Nancy R. Cook, ScD; I-Min Lee, MD, ScD; Julie E. Buring, ScD; JoAnn E. Manson, MD, DrPH
open access
JAMA Netw Open. 2023; 6(1):e2250681. 10.1001/jamanetworkopen.2022.50681
This cohort study examines the metabolism of and response to vitamin D supplementation in individuals by levels of vitamin D–related serum biomarkers in association with adiposity.
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JAMA Cardiology Original Investigation
November 23, 2022
Mark A. Hlatky, MD; Pedro Engel Gonzalez, MD; JoAnn E. Manson, MD, DrPH; Julie E. Buring, ScD; I-Min Lee, MBBS, ScD; Nancy R. Cook, ScD; Samia Mora, MD, MHS; Vadim Bubes, PhD; Neil J. Stone, MD
free access
JAMA Cardiol. 2022; 8(1):74-80. 10.1001/jamacardio.2022.4250
This study assesses whether vitamin D supplementation prevents statin-associated muscle symptoms and reduces statin discontinuation.
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JAMA Network Open Original Investigation Geriatrics
September 13, 2022
Ariela R. Orkaby, MD, MPH; Rimma Dushkes, PhD; Rachel Ward, PhD; Luc Djousse, MD, ScD; Julie E. Buring, ScD; I-Min Lee, MBBS, ScD; Nancy R. Cook, ScD; Meryl S. LeBoff, MD; Olivia I. Okereke, MD, SM; Trisha Copeland, MS, RD; JoAnn E. Manson, MD, DrPH
open access
JAMA Netw Open. 2022; 5(9):e2231206. 10.1001/jamanetworkopen.2022.31206
This ancillary study of a randomized clinical trial investigates the effects of vitamin D3 with omega-3 fatty acid supplementation on frailty in older adults.
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JAMA Ophthalmology Original Investigation
June 9, 2022
William G. Christen, ScD; Nancy R. Cook, ScD; JoAnn E. Manson, MD, DrPH; Julie E. Buring, ScD; I-Min Lee, MBBS, ScD; Vadim Bubes, PhD; Georgina Friedenberg, MPH; Rimma Dushkes, PhD; Douglas Smith, BS; Debra A. Schaumberg, ScD, OD, MPH; VITAL Research Group
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JAMA Ophthalmol. 2022; 140(7):707-714. 10.1001/jamaophthalmol.2022.1818
This randomized clinical trial evaluates the impact of daily ω-3 supplementation on the development of incident dry eye disease.
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JAMA Original Investigation
December 21, 2021
Olivia I. Okereke, MD, SM; Chirag M. Vyas, MBBS, MPH; David Mischoulon, MD, PhD; Grace Chang, MD, MPH; Nancy R. Cook, ScD; Alison Weinberg, MA; Vadim Bubes, PhD; Trisha Copeland, MS, RD; Georgina Friedenberg, MPH; I-Min Lee, MBBS, ScD; Julie E. Buring, ScD; Charles F. Reynolds III, MD; JoAnn E. Manson, MD, DrPH
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JAMA. 2021; 326(23):2385-2394. 10.1001/jama.2021.21187
This randomized clinical trial tested the effects of daily omega-3 supplementation vs placebo on depression prevention in older adults without depression.
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JAMA Original Investigation
March 16, 2021
Christine M. Albert, MD, MPH; Nancy R. Cook, ScD; Julie Pester, BA; M. Vinayaga Moorthy, PhD; Claire Ridge, MPH; Jacqueline S. Danik, MD, DrPH; Baris Gencer, MD; Hasan K. Siddiqi, MD, MSCR; Chee Ng, MD; Heike Gibson, PhD; Samia Mora, MD, MHS; Julie E. Buring, ScD; JoAnn E. Manson, MD, DrPH
free access
JAMA. 2021; 325(11):1061-1073. 10.1001/jama.2021.1489
This 2 × 2 factorial trial compares the effects of omega-3 fatty acids (460 mg/d of EPA and 380 mg/d of DHA) vs placebo, vitamin D₃ vs placebo, both, or neither on risk of incident atrial fibrillation (AF) among adults aged 50 years or older over a median of more than 5 years of treatment.
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JAMA Network Open Original Investigation Oncology
November 18, 2020
Paulette D. Chandler, MD, MPH; Wendy Y. Chen, MD, MPH; Oluremi N. Ajala, MD, MPH; Aditi Hazra, PhD, MPH; Nancy Cook, ScD; Vadim Bubes, PhD; I-Min Lee, MBBS, ScD; Edward L. Giovannucci, MD, ScD; Walter Willett, MD, DrPH; Julie E. Buring, ScD; JoAnn E. Manson, MD, DrPH; VITAL Research Group
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JAMA Netw Open. 2020; 3(11):e2025850. 10.1001/jamanetworkopen.2020.25850
This secondary analysis of a randomized clinical trial evaluates the effect vitamin D on the incidence of advanced (metastatic or fatal) cancer among adults without cancer at baseline and examines possible effect modification by body mass index.
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JAMA Ophthalmology Original Investigation
October 29, 2020
William G. Christen, ScD; Nancy R. Cook, ScD; JoAnn E. Manson, MD, DrPH; Julie E. Buring, ScD; Daniel I. Chasman, PhD; I-Min Lee, MBBS, ScD; Vadim Bubes, PhD; Chunying Li, PhD; Margarette Haubourg; Debra A. Schaumberg, ScD; VITAL Research Group
free access
JAMA Ophthalmol. 2020; 138(12):1280-1289. 10.1001/jamaophthalmol.2020.4409
This prespecified ancillary analysis of the VITAL (Vitamin D and Omega-3 Trial) nationwide randomized clinical trial assesses whether daily supplementation for approximately 4 to 6 years with vitamin D3, marine ω-3 fatty acids, or both vs placebo prevents the development or progression of age-related macular degeneration in initially healthy US adults.
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JAMA Original Investigation
August 4, 2020
Olivia I. Okereke, MD, SM; Charles F. Reynolds III, MD; David Mischoulon, MD, PhD; Grace Chang, MD, MPH; Chirag M. Vyas, MBBS, MPH; Nancy R. Cook, ScD; Alison Weinberg, MA; Vadim Bubes, PhD; Trisha Copeland, MS, RD; Georgina Friedenberg, MPH; I-Min Lee, MBBS, ScD; Julie E. Buring, ScD; JoAnn E. Manson, MD, DrPH
free access
JAMA. 2020; 324(5):471-480. 10.1001/jama.2020.10224
This randomized clinical trial compares the effects of vitamin D₃ supplementation vs placebo on depression risk and mood scores in men and women aged 50 years or older.
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JAMA Original Investigation
June 9, 2020
Tobias Kurth, MD, ScD; Pamela M. Rist, ScD; Paul M Ridker, MD, MPH; Gregory Kotler, PhD; Vadim Bubes, PhD; Julie E. Buring, ScD
free access
JAMA. 2020; 323(22):2281-2289. 10.1001/jama.2020.7172
This cohort study uses Women’s Health Study data to compare the association of migraine with aura vs other major vascular risk factors (diabetes, hypertension, dyslipidemia, smoking, BMI, CVD family history) with incidence of cardiovascular disease.
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JAMA Original Investigation
November 8, 2019
Ian H. de Boer, MD, MS; Leila R. Zelnick, PhD; John Ruzinski, BS; Georgina Friedenberg, MPH; Julie Duszlak, BS; Vadim Y. Bubes, PhD; Andrew N. Hoofnagle, MD, PhD; Ravi Thadhani, MD, MPH; Robert J. Glynn, PhD, ScD; Julie E. Buring, ScD; Howard D. Sesso, ScD, MPH; JoAnn E. Manson, MD, DrPH
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JAMA. 2019; 322(19):1899-1909. 10.1001/jama.2019.17380
This 2 × 2 factorial trial compares the effects of vitamin D3 vs placebo and omega-3 fatty acids vs placebo on change in glomerular filtration rate estimated from serum creatinine and cystatin C (eGFR) over 5 years in adults with type 2 diabetes.
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JAMA Oncology Original Investigation
November 21, 2019
Mingyang Song, MD, ScD; I-Min Lee, MD, ScD; JoAnn E. Manson, MD, DrPH; Julie E. Buring, ScD; Rimma Dushkes, MS; David Gordon, MAT; Joseph Walter, BS; Kana Wu, MD, PhD; Andrew T. Chan, MD, MPH; Shuji Ogino, MD, PhD; Charles S. Fuchs, MD, MPH; Jeffrey A. Meyerhardt, MD, MPH; Edward L. Giovannucci, MD, ScD; for the VITAL Research Group
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JAMA Oncol. 2019; 6(1):108-115. 10.1001/jamaoncol.2019.4587
This prespecified ancillary study of a randomized clinical trial compares the effects of daily marine ω-3 fatty acid supplementation vs placebo on risk of colorectal cancer precursors, including conventional adenomas and serrated polyps, in an average-risk US population.
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JAMA Internal Medicine Original Investigation
May 29, 2019
I-Min Lee, MBBS, ScD; Eric J. Shiroma, ScD; Masamitsu Kamada, PhD; David R. Bassett, PhD; Charles E. Matthews, PhD; Julie E. Buring, ScD
free access
JAMA Intern Med. 2019; 179(8):1105-1112. 10.1001/jamainternmed.2019.0899
This cohort study of 16 741 older women from the Women’s Health Study examines associations of number of steps per day and stepping intensity with all-cause mortality.
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JAMA Cardiology Original Investigation
June 1, 2017
Susanne Rautiainen, PhD; J. Michael Gaziano, MD, MPH; William G. Christen, ScD; Vadim Bubes, PhD; Gregory Kotler, PhD; Robert J. Glynn, ScD; JoAnn E. Manson, MD, DrPH; Julie E. Buring, ScD; Howard D. Sesso, ScD, MPH
free access
JAMA Cardiol. 2017; 2(6):617-625. 10.1001/jamacardio.2017.0176
This secondary analysis of the Physicians’ Health Study II randomized clinical trial investigates effect modification by various baseline dietary factors on cardiovascular disease risk.
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JAMA Editorial
March 28, 2017
JoAnn E. Manson, MD, DrPH; Shari S. Bassuk, ScD; Julie E. Buring, ScD
JAMA. 2017; 317(12):1217-1218. 10.1001/jama.2017.2155
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JAMA Oncology Original Investigation
October 1, 2016
Paige Maas, PhD; Myrto Barrdahl, PhD; Amit D. Joshi, PhD; Paul L. Auer, PhD; Mia M. Gaudet, PhD; Roger L. Milne, PhD; Fredrick R. Schumacher, PhD; William F. Anderson, MD, MPH; David Check, BS; Subham Chattopadhyay, BS; Laura Baglietto, PhD; Christine D. Berg, PhD; Stephen J. Chanock, MD; David G. Cox, PhD; Jonine D. Figueroa, PhD; Mitchell H. Gail, MD, PhD; Barry I. Graubard, PhD; Christopher A. Haiman, ScD; Susan E. Hankinson, ScD; Robert N. Hoover, MD, ScD; Claudine Isaacs, MD; Laurence N. Kolonel, PhD; Loic Le Marchand, MD, PhD; I-Min Lee, ScD; Sara Lindström, PhD; Kim Overvad, PhD; Isabelle Romieu, MD, MPH, ScD; Maria-Jose Sanchez, PhD; Melissa C. Southey, PhD; Daniel O. Stram, PhD; Rosario Tumino, PhD; Tyler J. VanderWeele, PhD; Walter C. Willett, MD, DrPh; Shumin Zhang, PhD; Julie E. Buring, ScD; Federico Canzian, PhD; Susan M. Gapstur, PhD; Brian E. Henderson, MD; David J. Hunter, MBBS, ScD; Graham G Giles, PhD; Ross L. Prentice, PhD; Regina G. Ziegler, PhD, MPH; Peter Kraft, PhD; Montse Garcia-Closas, MPH, DrPH; Nilanjan Chatterjee, PhD
open access
JAMA Oncol. 2016; 2(10):1295-1302. 10.1001/jamaoncol.2016.1025
This study uses data from the Breast and Prostate Cancer Cohort Consortium and the National Health Interview Survey to develop a model predicting the absolute risk of breast cancer for white women in the United States.
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JAMA Cardiology Original Investigation
July 1, 2016
David Conen, MD, MPH; Jorge A. Wong, MD, MPH; Roopinder K. Sandhu, MD, MPH; Nancy R. Cook, ScD; I-Min Lee, MD, ScD; Julie E. Buring, ScD; Christine M. Albert, MD, MPH
free access
JAMA Cardiol. 2016; 1(4):389-396. 10.1001/jamacardio.2016.0280
This large, long-term prospective cohort study evaluates the associations between atrial fibrillation and cancer.
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JAMA Original Contribution ONLINE FIRST
November 14, 2012
J. Michael Gaziano, MD, MPH; Howard D. Sesso, ScD, MPH; William G. Christen, ScD; Vadim Bubes, PhD; Joanne P. Smith, BA; Jean MacFadyen, BA; Miriam Schvartz, MD; JoAnn E. Manson, MD, DrPH; Robert J. Glynn, ScD; Julie E. Buring, ScD
free access
JAMA. 2012; 308(18):1871-1880. 10.1001/jama.2012.14641
To determine whether long-term multivitamin supplementation decreases the risk of total and site-specific cancer events among men, Gaziano and coauthors tested a multivitamin regimen on 14 641 US male physicians. See related Editorial by Bach and Lewis.
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JAMA Original Contribution
November 7, 2012
Howard D. Sesso, ScD, MPH; William G. Christen, ScD; Vadim Bubes, PhD; Joanne P. Smith, BA; Jean MacFadyen, BA; Miriam Schvartz, MD; JoAnn E. Manson, MD, DrPH; Robert J. Glynn, ScD; Julie E. Buring, ScD; J. Michael Gaziano, MD, MPH
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JAMA. 2012; 308(17):1751-1760. 10.1001/jama.2012.14805
To determine whether long-term multivitamin supplementation decreases the risk of major cardiovascular events among men, Sesso and coauthors randomized 14 641 male physicians participating in the Physicians’ Health Study II to receive a multivitamin or placebo. Lonn provides comment in the related Editorial.