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JAMA Network Open Original Investigation Nutrition, Obesity, and Exercise
January 17, 2023
Deirdre K. Tobias, ScD; Heike Luttmann-Gibson, PhD; Samia Mora, MD, MHS; Jacqueline Danik, MD, DrPH; Vadim Bubes, PhD; Trisha Copeland, MS, RD; Meryl S. LeBoff, MD; Nancy R. Cook, ScD; I-Min Lee, MD, ScD; Julie E. Buring, ScD; JoAnn E. Manson, MD, DrPH
open access
JAMA Netw Open. 2023; 6(1):e2250681. 10.1001/jamanetworkopen.2022.50681
This cohort study examines the metabolism of and response to vitamin D supplementation in individuals by levels of vitamin D–related serum biomarkers in association with adiposity.
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JAMA Network Open Original Investigation Oncology
November 18, 2020
Paulette D. Chandler, MD, MPH; Wendy Y. Chen, MD, MPH; Oluremi N. Ajala, MD, MPH; Aditi Hazra, PhD, MPH; Nancy Cook, ScD; Vadim Bubes, PhD; I-Min Lee, MBBS, ScD; Edward L. Giovannucci, MD, ScD; Walter Willett, MD, DrPH; Julie E. Buring, ScD; JoAnn E. Manson, MD, DrPH; VITAL Research Group
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JAMA Netw Open. 2020; 3(11):e2025850. 10.1001/jamanetworkopen.2020.25850
This secondary analysis of a randomized clinical trial evaluates the effect vitamin D on the incidence of advanced (metastatic or fatal) cancer among adults without cancer at baseline and examines possible effect modification by body mass index.
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JAMA Cardiology Original Investigation
November 23, 2022
Mark A. Hlatky, MD; Pedro Engel Gonzalez, MD; JoAnn E. Manson, MD, DrPH; Julie E. Buring, ScD; I-Min Lee, MBBS, ScD; Nancy R. Cook, ScD; Samia Mora, MD, MHS; Vadim Bubes, PhD; Neil J. Stone, MD
free access
JAMA Cardiol. 2022; 8(1):74-80. 10.1001/jamacardio.2022.4250
This study assesses whether vitamin D supplementation prevents statin-associated muscle symptoms and reduces statin discontinuation.
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JAMA Network Open Original Investigation Geriatrics
September 13, 2022
Ariela R. Orkaby, MD, MPH; Rimma Dushkes, PhD; Rachel Ward, PhD; Luc Djousse, MD, ScD; Julie E. Buring, ScD; I-Min Lee, MBBS, ScD; Nancy R. Cook, ScD; Meryl S. LeBoff, MD; Olivia I. Okereke, MD, SM; Trisha Copeland, MS, RD; JoAnn E. Manson, MD, DrPH
open access
JAMA Netw Open. 2022; 5(9):e2231206. 10.1001/jamanetworkopen.2022.31206
This ancillary study of a randomized clinical trial investigates the effects of vitamin D3 with omega-3 fatty acid supplementation on frailty in older adults.
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JAMA Cardiology Original Investigation
August 31, 2022
Hasan K. Siddiqi, MD, MSCR; Manickavasagar Vinayagamoorthy, PhD; Baris Gencer, MD; Chee Ng, MD; Julie Pester, BA; Nancy R. Cook, ScD; I-Min Lee, MBBS, ScD; Julie Buring, ScD; JoAnn E. Manson, MD, DrPH; Christine M. Albert, MD, MPH
free access
JAMA Cardiol. 2022; 7(10):1027-1035. 10.1001/jamacardio.2022.2825
This cohort study investigates the association between risk factors for atrial fibrillation and patient sex.
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JAMA Ophthalmology Original Investigation
June 9, 2022
William G. Christen, ScD; Nancy R. Cook, ScD; JoAnn E. Manson, MD, DrPH; Julie E. Buring, ScD; I-Min Lee, MBBS, ScD; Vadim Bubes, PhD; Georgina Friedenberg, MPH; Rimma Dushkes, PhD; Douglas Smith, BS; Debra A. Schaumberg, ScD, OD, MPH; VITAL Research Group
free access
JAMA Ophthalmol. 2022; 140(7):707-714. 10.1001/jamaophthalmol.2022.1818
This randomized clinical trial evaluates the impact of daily ω-3 supplementation on the development of incident dry eye disease.
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JAMA Original Investigation
December 21, 2021
Olivia I. Okereke, MD, SM; Chirag M. Vyas, MBBS, MPH; David Mischoulon, MD, PhD; Grace Chang, MD, MPH; Nancy R. Cook, ScD; Alison Weinberg, MA; Vadim Bubes, PhD; Trisha Copeland, MS, RD; Georgina Friedenberg, MPH; I-Min Lee, MBBS, ScD; Julie E. Buring, ScD; Charles F. Reynolds III, MD; JoAnn E. Manson, MD, DrPH
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JAMA. 2021; 326(23):2385-2394. 10.1001/jama.2021.21187
This randomized clinical trial tested the effects of daily omega-3 supplementation vs placebo on depression prevention in older adults without depression.
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JAMA Ophthalmology Comment & Response
April 29, 2021
William G. Christen, ScD; Nancy R. Cook, ScD; JoAnn E. Manson, MD, DrPH
JAMA Ophthalmol. 2021; 139(6):677-677. 10.1001/jamaophthalmol.2021.1040
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JAMA Original Investigation
March 16, 2021
Christine M. Albert, MD, MPH; Nancy R. Cook, ScD; Julie Pester, BA; M. Vinayaga Moorthy, PhD; Claire Ridge, MPH; Jacqueline S. Danik, MD, DrPH; Baris Gencer, MD; Hasan K. Siddiqi, MD, MSCR; Chee Ng, MD; Heike Gibson, PhD; Samia Mora, MD, MHS; Julie E. Buring, ScD; JoAnn E. Manson, MD, DrPH
free access
JAMA. 2021; 325(11):1061-1073. 10.1001/jama.2021.1489
This 2 × 2 factorial trial compares the effects of omega-3 fatty acids (460 mg/d of EPA and 380 mg/d of DHA) vs placebo, vitamin D₃ vs placebo, both, or neither on risk of incident atrial fibrillation (AF) among adults aged 50 years or older over a median of more than 5 years of treatment.
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JAMA Ophthalmology Original Investigation
October 29, 2020
William G. Christen, ScD; Nancy R. Cook, ScD; JoAnn E. Manson, MD, DrPH; Julie E. Buring, ScD; Daniel I. Chasman, PhD; I-Min Lee, MBBS, ScD; Vadim Bubes, PhD; Chunying Li, PhD; Margarette Haubourg; Debra A. Schaumberg, ScD; VITAL Research Group
free access
JAMA Ophthalmol. 2020; 138(12):1280-1289. 10.1001/jamaophthalmol.2020.4409
This prespecified ancillary analysis of the VITAL (Vitamin D and Omega-3 Trial) nationwide randomized clinical trial assesses whether daily supplementation for approximately 4 to 6 years with vitamin D3, marine ω-3 fatty acids, or both vs placebo prevents the development or progression of age-related macular degeneration in initially healthy US adults.
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JAMA Network Open Original Investigation Statistics and Research Methods
September 16, 2020
Jan Vollert, PhD; Nancy R. Cook, ScD; Ted J. Kaptchuk; Shiv T. Sehra, MD; Deirdre K. Tobias, PhD; Kathryn T. Hall, PhD
open access
JAMA Netw Open. 2020; 3(9):e2013196. 10.1001/jamanetworkopen.2020.13196
This cross-sectional study examines subjective vs objective responses to placebo administration in clinical trials on patients with rheumatoid arthritis.
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JAMA Original Investigation
August 4, 2020
Olivia I. Okereke, MD, SM; Charles F. Reynolds III, MD; David Mischoulon, MD, PhD; Grace Chang, MD, MPH; Chirag M. Vyas, MBBS, MPH; Nancy R. Cook, ScD; Alison Weinberg, MA; Vadim Bubes, PhD; Trisha Copeland, MS, RD; Georgina Friedenberg, MPH; I-Min Lee, MBBS, ScD; Julie E. Buring, ScD; JoAnn E. Manson, MD, DrPH
free access
JAMA. 2020; 324(5):471-480. 10.1001/jama.2020.10224
This randomized clinical trial compares the effects of vitamin D₃ supplementation vs placebo on depression risk and mood scores in men and women aged 50 years or older.
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JAMA Network Open Original Investigation Psychiatry
March 26, 2020
Chirag M. Vyas, MBBS, MPH; Macarius Donneyong, PhD, MPH; David Mischoulon, MD, PhD; Grace Chang, MD, MPH; Heike Gibson, PhD; Nancy R. Cook, ScD; JoAnn E. Manson, MD, DrPH; Charles F. Reynolds III, MD; Olivia I. Okereke, MD, SM
open access
JAMA Netw Open. 2020; 3(3):e201606. 10.1001/jamanetworkopen.2020.1606
This cross-sectional study examines racial/ethnic differences in depression severity, symptom burden, and care among older community-dwelling adults in the United States.
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JAMA Network Open Original Investigation Oncology
December 6, 2019
Greg J. Haro, MD; Bonnie Sheu, MD; Nancy R. Cook, ScD; Gavitt A. Woodard, MD; Michael J. Mann, MD; Johannes R. Kratz, MD
open access
JAMA Netw Open. 2019; 2(12):e1917062. 10.1001/jamanetworkopen.2019.17062
This cohort study examines whether incorporation of a molecular prognostic classifier into conventional TNM staging for non–small cell lung cancer improves estimation of disease-free survival.
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JAMA Comment & Response
October 9, 2018
Edward K. Duran, MD; Nancy R. Cook, ScD; Paul M. Ridker, MD
JAMA. 2018; 320(14):1493-1493. 10.1001/jama.2018.11202
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JAMA Internal Medicine Original Investigation
September 1, 2018
Samia Mora, MD, MHS; Nanette K. Wenger, MD; Nancy R. Cook, ScD; Jingmin Liu, MS; Barbara V. Howard, PhD; Marian C. Limacher, MD; Simin Liu, MD, ScD; Karen L. Margolis, MD, MPH; Lisa W. Martin, MD; Nina P. Paynter, PhD; Paul M Ridker, MD, MPH; Jennifer G. Robinson, MD, MPH; Jacques E. Rossouw, MD; Monika M. Safford, MD; JoAnn E. Manson, MD, DrPH
free access
JAMA Intern Med. 2018; 178(9):1231-1240. 10.1001/jamainternmed.2018.2875
This study evaluates the pooled cohort equation’s accuracy for predicting 10-year risk of atherosclerotic cardiovascular disease among participants in the Women’s Health Initiative.
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JAMA Cardiology Original Investigation
July 1, 2018
Neal A. Chatterjee, MD, MSc; M. Vinayaga Moorthy, PhD; Julie Pester, BA; Andi Schaecter, BA; Gopi K. Panicker, BHMS, PGDCR; Dhiraj Narula, MD; Daniel C. Lee, MD, MS; Jeffrey J. Goldberger, MD, MBA; Alan Kadish, MD; Nancy R. Cook, ScD; Christine M. Albert, MD, MPH; for the PRE-DETERMINE Study Group
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JAMA Cardiol. 2018; 3(7):591-600. 10.1001/jamacardio.2018.1049
This cohort study provides contemporary estimates of sudden and/or arrhythmic death vs other competing causes of death in patients with coronary heart disease without severe systolic dysfunction to search for high-risk subgroups that might be targeted in future trials of prevention of sudden and/or arrhythmic death.
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JAMA Internal Medicine Original Investigation
September 27, 2010
Chun Chao, PhD; Yiqing Song, MD, ScD; Nancy Cook, ScD; Chi-Hong Tseng, PhD; JoAnn E. Manson, MD, DrPH; Charles Eaton, MD; Karen L. Margolis, MD; Beatriz Rodriguez, MD, PhD; Lawrence S. Phillips, MD; Lesley F. Tinker, PhD, RD; Simin Liu, MD, ScD
free access
Arch Intern Med. 2010; 170(17):1557-1565. 10.1001/archinternmed.2010.312
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JAMA Cardiology Original Investigation
July 1, 2016
David Conen, MD, MPH; Jorge A. Wong, MD, MPH; Roopinder K. Sandhu, MD, MPH; Nancy R. Cook, ScD; I-Min Lee, MD, ScD; Julie E. Buring, ScD; Christine M. Albert, MD, MPH
free access
JAMA Cardiol. 2016; 1(4):389-396. 10.1001/jamacardio.2016.0280
This large, long-term prospective cohort study evaluates the associations between atrial fibrillation and cancer.
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JAMA Internal Medicine Original Investigation
December 1, 2014
Nancy R. Cook, ScD; Paul M Ridker, MD
free access
JAMA Intern Med. 2014; 174(12):1964-1971. 10.1001/jamainternmed.2014.5336
The Women’s Health Study is a nationwide cohort of US women free of cardiovascular disease, cancer, or other major illness at baseline from 1992 to 1995. A total of 27 542 women aged 45 to 79 years with complete ascertainment of plasma lipids and other risk factors were followed for a median of 10 years.