Interferons as Inducers of Apoptosis in Malignant Cells
Publication: Journal of Interferon & Cytokine Research
Volume 33, Issue Number 4
Abstract
Discovered as antiviral cytokines, interferons (IFNs) are now also recognized for their capacity to inhibit the growth of malignant cells via activation of programmed cell death, better known as apoptosis. In this review, we will cover recent advances made in this field, as it pertains to the various proposed mechanisms of IFN-induced apoptosis and the characterization of IFN-responsive genes not previously known to have apoptotic function. Also mentioned here is a description of the activation and crosstalk of survival signaling pathways as a mode of IFN resistance that remains a persistent clinical adversary to overcome and the future of IFNs as antitumor agents.
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Published In
Journal of Interferon & Cytokine Research
Volume 33 • Issue Number 4 • April 2013
Pages: 162 - 170
PubMed: 23570382
Copyright
Copyright 2013, Mary Ann Liebert, Inc.
History
Published online: 9 April 2013
Published in print: April 2013
Accepted: 27 November 2012
Received: 18 September 2012
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