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Abstract

Background:

Anomalous aortic origin of a coronary artery (AAOCA) encompasses a wide morphologic spectrum, which has impeded consensus regarding indications for the diverse repair strategies. We constructed a profile of current surgical techniques and explore their application to morphologic variants.

Methods:

Patients <30 years old (n = 113) with isolated AAOCA who underwent operations at 29 Congenital Heart Surgeons Society (CHSS) institutions from 1998 to 2012 were identified from the CHSS AAOCA Registry. Operative findings were related to surgical techniques at index repairs by cross-tabulation.

Results:

Anomalous origin of the left main or left anterior descending coronary artery was present in 33 (29%) patients and of the right coronary artery in 78 (69%) patients; 2 arteries originated directly above the commissure between the left and right sinuses. There were 101 (89%) interarterial and intramural (IA/IM) arteries, 10 (9%) were interarterial but not intramural (IA/NIM) and 2 (2%) were neither interarterial nor intramural. Intramural arteries were unroofed in 100 (88%) operations, usually with intimal tacking after incision (n = 47) or excision (n = 25) of the common wall. Coronary reimplantation (n = 11), pulmonary artery relocation (n = 7; 5 for IA/NIM), simple ostioplasty (without unroofing; n = 3), coronary artery bypass grafting (n = 2), and ostial window (n = 1) were less common. In 37 (33%) operations, a valvar commissure was taken down; 33 were resuspended.

Conclusion:

Current surgical repair of AAOCA is individualized to morphology, particularly the presence of intramural and/or interarterial segments. This report is foundational for future planned CHSS studies that will examine interventional and noninterventional outcomes and ultimately guide management of AAOCA.

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References

1. Topaz O, DeMarchena EJ, Perin E, Sommer LS, Mallon SM, Chahine RA. Anomalous coronary arteries: angiographic findings in 80 patients. Int J Cardiol. 1992;34(2):129–138.
2. Yamanaka O, Hobbs RE. Coronary artery anomalies in 126,595 patients undergoing coronary arteriography. Cathet Cardiovasc Diagn. 1990;21(1):28–40.
3. Gersony WM. Management of anomalous coronary artery from the contralateral coronary sinus. J Am Coll Cardiol. 2007;50(21):2083–2084.
4. Angelini P. Coronary artery anomalies: an entity in search of an identity. Circulation. 2007;115(10):1296–1305.
5. Girzadas M, Varga P, Dajani K. A single-center experience of detecting coronary anomalies on 64-slice computed tomography. J Cardiovasc Med (Hagerstown). 2009;10(11):842–847.
6. Miller JA, Anavekar NS, El Yaman MM, Burkhart HM, Miller AJ, Julsrud PR. Computed tomographic angiography identification of intramural segments in anomalous coronary arteries with interarterial course. Int J Cardiovasc Imaging. 2012;28(6):1525–1532.
7. Davies JE, Burkhart HM, Dearani JA, et al. Surgical management of anomalous aortic origin of a coronary artery. Ann Thorac Surg. 2009;88(3):844–847; discussion 847–848.
8. Frommelt PC, Frommelt MA, Tweddell JS, Jaquiss RD. Prospective echocardiographic diagnosis and surgical repair of anomalous origin of a coronary artery from the opposite sinus with an interarterial course. J Am Coll Cardiol. 2003;42(1):148–154.
9. Reul RM, Cooley DA, Hallman GL, Reul GJ. Surgical treatment of coronary artery anomalies: report of a 37 1/2-year experience at the Texas heart institute. Tex Heart Inst J. 2002;29(4):299–307.
10. Brothers JA, Gaynor JW, Jacobs JP, Caldarone C, Jegatheeswaran A, Jacobs ML. The registry of anomalous aortic origin of the coronary artery of the Congenital Heart Surgeons' Society. Cardiol Young. 2010;20(suppl 3):50–58.
11. Poynter JA, Williams WG, McIntyre S, Brothers JA, Jacobs ML. Anomalous aortic origin of a coronary artery: a report from the Congenital Heart Surgeons’ Society registry. World J Pediatr Congenit Heart Surg. 2014;5(1):22–30.
12. Basso C, Maron BJ, Corrado D, Thiene G. Clinical profile of congenital coronary artery anomalies with origin from the wrong aortic sinus leading to sudden death in young competitive athletes. J Am Coll Cardiol. 2000;35(6):1493–1501.
13. Frommelt PC, Sheridan DC, Berger S, Frommelt MA, Tweddell JS. Ten-year experience with surgical unroofing of anomalous aortic origin of a coronary artery from the opposite sinus with an interarterial course. J Thorac Cardiovasc Surg. 2011;142(5):1046–1051.
14. Mavroudis C, Backer CL. Technical tips for three congenital heart operations: modified Ross-Konno procedure, optimal ventricular septal defect exposure by tricuspid valve incision, coronary unroofing, and endarterectomy for anomalous aortic origin of the coronary artery. Oper Tech Thorac Cardiovasc Surg. 2010;15(1):18–40.
15. Mumtaz MA, Lorber RE, Arruda J, Pettersson GB, Mavroudis C. Surgery for anomalous aortic origin of the coronary artery. Ann Thorac Surg. 2011;91(3):811–814; discussion 814–815.
16. Mavroudis C, Dodge-Khatami A, Stewart RD, Jacobs ML, Backer CL, Lorber RE. An overview of surgery options for congenital coronary artery anomalies. Fut Cardiol. 2010;6(5):627–645.
17. Mainwaring RD, Reddy VM, Reinhartz O, et al. Anomalous aortic origin of a coronary artery: medium-term results after surgical repair in 50 patients. Ann Thorac Surg. 2011;92(2):691–697.
18. Gulati R, Reddy VM, Culbertson C, et al. Surgical management of coronary artery arising from the wrong coronary sinus, using standard and novel approaches. J Thorac Cardiovasc Surg. 2007;134(5):1171–1178.
19. Backer CL, Stout MJ, Zales VR, et al. Anomalous origin of the left coronary artery. A twenty-year review of surgical management. J Thorac Cardiovasc Surg. 1992;103(6):1049–1057; discussion 1057–1048.
20. Rodefeld MD, Culbertson CB, Rosenfeld HM, Hanley FL, Thompson LD. Pulmonary artery translocation: a surgical option for complex anomalous coronary artery anatomy. Ann Thorac Surg. 2001;72(6):2150–2152.
21. Brothers JA, McBride MG, Seliem MA, et al. Evaluation of myocardial ischemia after surgical repair of anomalous aortic origin of a coronary artery in a series of pediatric patients. J Am Coll Cardiol. 2007;50(21):2078–2082.
22. Brothers J, Gaynor JW, Paridon S, Lorber R, Jacobs M. Anomalous aortic origin of a coronary artery with an interarterial course: understanding current management strategies in children and young adults. Pediatr Cardiol. 2009;30(7):911–921.
23. Turner II, Turek JW, Jaggers J, Herlong JR, Lawson DS, Lodge AJ. Anomalous aortic origin of a coronary artery: Preoperative diagnosis and surgical planning. World J Pediatr Congenit Heart Surg. 2011;2(3):340–345.
24. Guerra VC, Recto MR, Goldman C, Yeh T Jr. Anomalous aortic origin of the coronary artery: does pulmonary artery translocation affect coronary artery course? J Thorac Cardiovasc Surg. 2013;146(6):1549–1551.
25. Kaushal S, Backer CL, Popescu AR, et al. Intramural coronary length correlates with symptoms in patients with anomalous aortic origin of the coronary artery. Ann Thorac Surg. 2011;92(3):986–991; discussion 991–982.
26. Congenital Heart Surgeons Society Data Center. Available at www.chssdc.org/studies. Accessed June 24, 2014.

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Published In

Article first published online: October 16, 2014
Issue published: October 2014

Keywords

  1. congenital heart disease
  2. congenital heart surgery
  3. coronary artery anomaly
  4. myocardial morphology

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© The Author(s) 2014.
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PubMed: 25324246

Authors

Affiliations

Jeffrey A. Poynter, MD, MSc
Congenital Heart Surgeons Society Data Center, The Hospital for Sick Children, Toronto, Ontario, Canada
Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA
Igor Bondarenko, MD, PhD
Department of Cardiovascular Surgery, Children’s Hospital of Michigan, Detroit, MI, USA
Erle H. Austin, MD
Kosair Children’s Hospital, University of Louisville, Louisville, KY, USA
William M. DeCampli, MD, PhD
Department of Cardiothoracic Surgery, Arnold Palmer Hospital for Children, Orlando, FL, USA
Jeffrey P. Jacobs, MD
Johns Hopkins All Children's Heart Institute, Johns Hopkins University, All Children's Hospital, St Petersburg, FL, USA
Gerhard Ziemer, MD, PhD
Department of Surgery, University of Chicago, Chicago, IL, USA
Paul M. Kirshbom, MD
Cardiothoracic Surgery, Yale University, New Haven, CT, USA
Christo I. Tchervenkov, MD
Montreal Children’s Hospital, Montreal, PQ, Canada
Tara Karamlou, MD
Department of Pediatric Cardiac Surgery, University of California-San Francisco Benioff Children's Hospital, San Francisco, CA, USA
Eugene H. Blackstone, MD
Cleveland Clinic, Cleveland, OH, USA
Henry L. Walters, III, MD
Department of Cardiovascular Surgery, Children’s Hospital of Michigan, Detroit, MI, USA
J. William Gaynor, MD
Pediatric Cardiac Surgery, The Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA
Carlos M. Mery, MD, MPH
Division of Congenital Heart Surgery, Texas Children’s Hospital, Houston, TX, USA
Jeffrey M. Pearl, MD
Glendale Department of Childhealth, University of Arizona College of Medicine, Phoenix, AZ, USA
Julie A. Brothers, MD
Pediatric Cardiac Surgery, The Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA
Christopher A. Caldarone, MD
Division of Cardiac Surgery, University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada
William G. Williams, MD
Congenital Heart Surgeons Society Data Center, The Hospital for Sick Children, Toronto, Ontario, Canada
Marshall L. Jacobs, MD
Department of Surgery, Johns Hopkins School of Medicine, Baltimore, MD, USA
Constantine Mavroudis, MD
Johns Hopkins University, Florida Hospital for Children, Orlando, FL, USA
The Congenital Heart Surgeons’ Society AAOCA Working Group

Notes

Constantine Mavroudis, Johns Hopkins University, Florida Hospital for Children, 2501N. Orange Avenue, Suite 540, Orlando, FL 32804, USA. Email: [email protected]

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