Abstract
A series of caffeic acid amides were designed, synthesized and evaluated for anti-inflammatory activity. Most of them exhibited promising anti-inflammatory activity against nitric oxide (NO) generation in murine macrophage RAW264.7 cells. A 3D pharmacophore model was created based on the biological results for further structural optimization. Moreover, predication of the potential targets was also carried out by the PharmMapper server. These amide analogues represent a promising class of anti-inflammatory scaffold for further exploration and target identification.
Publication types
- Research Support, Non-U.S. Gov't
MeSH terms
- Animals
- Anti-Inflammatory Agents / chemical synthesis*
- Anti-Inflammatory Agents / chemistry
- Anti-Inflammatory Agents / metabolism
- Binding Sites
- Caffeic Acids / chemical synthesis
- Caffeic Acids / chemistry*
- Caffeic Acids / metabolism
- Catalytic Domain
- Cell Line
- Mice
- Molecular Docking Simulation
- Nitric Oxide / metabolism
- Orotidine-5'-Phosphate Decarboxylase / chemistry
- Orotidine-5'-Phosphate Decarboxylase / metabolism
- Phosphorus-Oxygen Lyases / genetics
- Phosphorus-Oxygen Lyases / metabolism
- Protein Binding
- Proto-Oncogene Proteins p21(ras) / genetics
- Proto-Oncogene Proteins p21(ras) / metabolism
- Structure-Activity Relationship
Substances
- Anti-Inflammatory Agents
- Caffeic Acids
- Nitric Oxide
- Hras protein, mouse
- Proto-Oncogene Proteins p21(ras)
- Orotidine-5'-Phosphate Decarboxylase
- chorismate synthase
- Phosphorus-Oxygen Lyases
- caffeic acid