AVINASH YADAV

Background: Inguinal hernia is one of the diseases that has haunted humanity from its very beginning to the modern times. Groin hernias are the most common conditions referred to surgeons all over the world and over five lakh hernia repairs are performed annually. The lifetime risk for men is 27.0% and for women is 3.0%. Approximately 75.0% of all abdominal wall hernias occur in the groin. Inguinal hernias are more common on the right than on the left and are seven times more likely in males than in females. Aims and Objectives: Aim and objective of the study is to compare extended total extra peritoneal (e-TEP) and total extra peritoneal (TEP) repair in terms of complications and recurrence. To evaluate ease of operability of e-TEP and TEP for inguinal hernia repair. Materials and Methods: Patients with inguinal hernia who were hospitalized to the Department of General Surgery at GSVM Medical College, Kanpur, and who were over the age of 18 years of both sexes were studied from Dec...

One-dimensional heat conduction in a longitudinal rectangular fin for different fin materials (AISI 316, Aluminium, Copper) have been numerically investigated. In the present study laminar, one-dimensional, steady state thermal conduction, convection is considered for the analysis. The heat energy balance equation for the concerned longitudinal rectangular fin is formulated and further solved in MATLAB R2014a for evaluating total heat transfer rate, fin efficiency and fin effectiveness. The same longitudinal rectangular fin is modelled and simulated in FLUENT solver of ANSYS R16. Obtained simulated results are validated with exact solutions found from MATLAB R2014a and these results show a good agreement between with both of results with some error. It is observed from the result that the thermal conductivity widely affects the heat transfer rate, fin efficiency and fin effectiveness. The result shows that heat transfer rate increases with the increase in thermal conductivity of mat...

Abstract EDM is one of the advanced machining process which is used to machine any electrically conductive material. Dielectric fluid is an unavoidable component in this process. Dielectric fluid plays a significant role on the characteristics of machining process such as tool wear rate (TWR), material removal rate (MRR) and more. Conventional dielectric fluid having disadvantages like they emit carbon die oxide, carbon mono oxide gases in the environment. Vegetable based bio-oil/ biodiesels are biodegradable, environment friendly and they emit less harmful gases. In this paper study of various waste vegetable oils used as dielectric fluid are considered and the overall effect on the EDM are analysed. The various properties of biodiesel/bio-oil such flash point, viscosity index, and surface roughness etc. are compared with the traditionally dielectric fluid. The study shows that the vegetable based biodiesel could be an alternate of traditional based oil. The High MRR, good surface area and effective TWR are observed from the study. The comparative study of Jatropha curcas oil and Kerosene oil shows that the jatropha curcas oil highly effective over kerosene.

Abstract The pollution has been increased around the globe due to the usage of petroleum products. In providing lubrication, synthetic lubricants are in use but their degradation is harmful due to their high toxicity. In order to reduce their application, non-edible vegetable oils are suitable alternatives. In this study, Schlichera oleosa was used as bio based lubricant. In this process, different loads were applied at constant sliding speed. At higher loads, more amount of friction and wear was observed. The reduction in friction and wear was obtained during the application of Schlichera oleosa bio based lubricant in comparison to the Schlichera oleosa oil. Also, minimum wear scar was formed during utilization of bio based lubricant.

Abstract The degradation of the environment showed interest in searching for an alternative possibilities of the conventional lubricants. Michelia Champaca oil was suitable in this direction due to its high viscosity and flash point. The oil was chemically modified before its usage as bio based lubricant. The different load was applied on the machine. The load was varied from 20 N to 50 N with a successive gap of 10 N. The sliding speed was considered 300 rpm and 3000 m sliding distance was taken during the analysis. The less friction was obtained at lower loads and it increases with respect to loads. The Michelia Champaca Showed less friction and wear at all the loads and also it showed less worn surface for all the conditions applied.

A systematic review on the heat transfer in microchannel heat exchangers with different geometries is presented. The slip and No-slip flow are accounted in this study. The two dimensional, three dimensional studies considered with single phase convective heat transfer microchannel with different geometries. Both theoretical and experimental studies are considered and comparison made between them. From the available experimental literature friction factor, Nusselt number is measured and they compared with the conventional theory and results shows that inequality between experiment and conventional theory results. The compressibility effect, roughness effect, viscous dissipation effect, variation in properties is also considered for find out the pressure drop. The results show that the pressure drop is the function of roughness. By paralleling the experimental data on single-phase convective heat transfer through microchannels, it is manifest that additional methodical studies are ess...

The absence of efficient mass spectrometry-based approaches for the large-scale analysis of protein arginine methylation has hindered the understanding of its biological role, beyond the transcriptional regulation occurring through histone modification. In the last decade, however, several technological advances of both the biochemical methods for methylated polypeptide enrichment and the computational pipelines for MS data analysis have considerably boosted this research field, generating novel insights about the extent and role of this post-translational modification. Here, we offer an overview of state-of-the-art approaches for the high-confidence identification and accurate quantification of protein arginine methylation by high-resolution mass spectrometry methods, which comprise the development of both biochemical and bioinformatics methods. The further optimization and systematic application of these analytical solutions will lead to ground-breaking discoveries on the role of ...

ABSTRACTProtein Arginine (R) methylation is a post-translational modification involved in various biological processes, such as RNA splicing, DNA repair, immune response, signal transduction, and tumour development. Although several advancements were made in the study of this modification by mass spectrometry, researchers still face the problem of a high false discovery rate. We present a dataset of high-quality methylations obtained from several different heavy methyl SILAC (hmSILAC) experiments analysed with a machine learning-based tool doublets and show that this model allows for improved high-confidence identification of real methyl-peptides. Overall, our results are consistent with the notion that protein R methylation modulates protein:RNA interactions and suggest a role in rewiring protein:protein interactions, for which we provide experimental evidence for a representative case (i.e. NONO:PSPC1). Upon intersecting our R-methyl-sites dataset with a phosphosites dataset, we o...