Population Dynamics of Immune Responses to Persistent Viruses
Abstract
Mathematical models, which are based on a firm understanding of biological interactions, can provide nonintuitive insights into the dynamics of host responses to infectious agents and can suggest new avenues for experimentation. Here, a simple mathematical approach is developed to explore the relation between antiviral immune responses, virus load, and virus diversity. The model results are compared to data on cytotoxic T cell responses and viral diversity in infections with the human T cell leukemia virus (HTLV-1) and the human immunodeficiency virus (HIV-1).
- Publication:
-
Science
- Pub Date:
- April 1996
- DOI:
- 10.1126/science.272.5258.74
- Bibcode:
- 1996Sci...272...74N