Chapter 15
COVID-19: Neurology Perspective
Kiandokht Keyhanian,
Raffaella Pizzolato Umeton,
Babak Mohit,
Brooke McNeilly,
Mehdi Ghasemi,
Kiandokht Keyhanian
Department of Neurology, University of Massachusetts Medical School, Worcester, MA, USA
Search for more papers by this authorRaffaella Pizzolato Umeton
Department of Neurology, University of Massachusetts Medical School, Worcester, MA, USA
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Search for more papers by this authorBabak Mohit
Sleep Disorders Center, Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
Search for more papers by this authorBrooke McNeilly
Department of Neurology, University of Massachusetts Medical School, Worcester, MA, USA
Search for more papers by this authorMehdi Ghasemi
Department of Neurology, University of Massachusetts Medical School, Worcester, MA, USA
Search for more papers by this author
Kiandokht Keyhanian,
Raffaella Pizzolato Umeton,
Babak Mohit,
Brooke McNeilly,
Mehdi Ghasemi,
Kiandokht Keyhanian
Department of Neurology, University of Massachusetts Medical School, Worcester, MA, USA
Search for more papers by this authorRaffaella Pizzolato Umeton
Department of Neurology, University of Massachusetts Medical School, Worcester, MA, USA
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Search for more papers by this authorBabak Mohit
Sleep Disorders Center, Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
Search for more papers by this authorBrooke McNeilly
Department of Neurology, University of Massachusetts Medical School, Worcester, MA, USA
Search for more papers by this authorMehdi Ghasemi
Department of Neurology, University of Massachusetts Medical School, Worcester, MA, USA
Search for more papers by this author
Book Editor(s):Ali Gholamrezanezhad MD,
Michael P. Dube MD,
Ali Gholamrezanezhad MD
Keck School of Medicine, University of Southern California (USC), Los Angeles, California, USA
Search for more papers by this authorMichael P. Dube MD
Keck School of Medicine, University of Southern California (USC), Los Angeles, California, USA
Search for more papers by this author
First published: 30 December 2022
Summary
COVID-19 is known to involve the nervous system, for which three pathways have been suggested: (i) retrograde through neurons, (ii) angiotensin-converting enzyme 2 (ACE-2) expression in neurons, and (iii) hematogenous dissemination. In addition, damage to the central nervous system is mediated by an indirect effect of the virus causing a cytokine storm. In this chapter, the pathophysiologic mechanism of the involvement of nervous system in COVID-19 and also its clinical manifestations and the diagnostic and therapeutic approach to the neurologic complications is reviewed.
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