Resveratrol metabolite profiling in clinical nutrition research—from diet to uncovering disease risk biomarkers: epidemiological evidence
Montserrat Rabassa
Nutrition and Food Science Department, Biomarkers and Nutrimetabolomics Lab., XaRTA, INSA, Faculty of Pharmacy and Food Sciences, University of Barcelona, Barcelona, Spain
These authors contributed equally to the manuscript.
Search for more papers by this authorRaul Zamora-Ros
Nutrition and Metabolism Section (NME), Biomarkers Group (BMA), International Agency for Research on Cancer (IARC), Lyon, France
These authors contributed equally to the manuscript.
Search for more papers by this authorMireia Urpi-Sarda
Nutrition and Food Science Department, Biomarkers and Nutrimetabolomics Lab., XaRTA, INSA, Faculty of Pharmacy and Food Sciences, University of Barcelona, Barcelona, Spain
Search for more papers by this authorCorresponding Author
Cristina Andres-Lacueva
Nutrition and Food Science Department, Biomarkers and Nutrimetabolomics Lab., XaRTA, INSA, Faculty of Pharmacy and Food Sciences, University of Barcelona, Barcelona, Spain
Address for correspondence: Cristina Andres-Lacueva, Nutrition and Food Science Department, Biomarkeys and Nutrimetabolomic Lab., XaRTA, INSA, Faculty of Pharmacy and Food Sciences, University of Barcelona, Av. Joan XXIII s/n, 08028 Barcelona, Spain. [email protected]Search for more papers by this authorMontserrat Rabassa
Nutrition and Food Science Department, Biomarkers and Nutrimetabolomics Lab., XaRTA, INSA, Faculty of Pharmacy and Food Sciences, University of Barcelona, Barcelona, Spain
These authors contributed equally to the manuscript.
Search for more papers by this authorRaul Zamora-Ros
Nutrition and Metabolism Section (NME), Biomarkers Group (BMA), International Agency for Research on Cancer (IARC), Lyon, France
These authors contributed equally to the manuscript.
Search for more papers by this authorMireia Urpi-Sarda
Nutrition and Food Science Department, Biomarkers and Nutrimetabolomics Lab., XaRTA, INSA, Faculty of Pharmacy and Food Sciences, University of Barcelona, Barcelona, Spain
Search for more papers by this authorCorresponding Author
Cristina Andres-Lacueva
Nutrition and Food Science Department, Biomarkers and Nutrimetabolomics Lab., XaRTA, INSA, Faculty of Pharmacy and Food Sciences, University of Barcelona, Barcelona, Spain
Address for correspondence: Cristina Andres-Lacueva, Nutrition and Food Science Department, Biomarkeys and Nutrimetabolomic Lab., XaRTA, INSA, Faculty of Pharmacy and Food Sciences, University of Barcelona, Av. Joan XXIII s/n, 08028 Barcelona, Spain. [email protected]Search for more papers by this authorAbstract
Resveratrol is a bioactive plant compound that has drawn scientific and media attention owing to its protective effects against a wide variety of illnesses, including cardiovascular diseases and cancer. In the last two decades, a plethora of preclinical studies have shown these beneficial effects, and some of them have been supported by clinical trials. However, there are few epidemiological studies assessing these relationships, showing mostly inconsistent results among them. This could be partially due to the difficulty of accurately estimating dietary resveratrol exposure. The development of Phenol-Explorer, a database containing resveratrol food-composition data, will facilitate the estimation of resveratrol intake. Moreover, the discovery and validation of a nutritional biomarker of this exposure, urinary resveratrol metabolite profile, will allow a more accurate assessment of dietary resveratrol exposure. Few epidemiological studies have assessed the potential health effects of resveratrol. Resveratrol was not associated with total mortality, cancer, or cardiovascular events, but it was associated with an improvement of serum glucose and triglyceride levels and a decrease in heart rate. Together, these findings suggest a potential cardioprotective effect of resveratrol in epidemiological studies, although the evidence is still scarce.
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