Mediterranean and Low-Fat Diets Improve Endothelial Function in Hypercholesterolemic Men
Publication: Annals of Internal Medicine
Volume 134, Number 12
Abstract
Background:
The regulatory function of the endothelium is altered in hypercholesterolemia, and the subsequent endothelial dysfunction plays a central role in the development of atherosclerosis.
Objective:
To determine whether endothelial function in hypercholesterolemic patients is affected by replacing a saturated fat–enriched diet with a low-fat, low–saturated fat diet (the U.S. National Cholesterol Education Program stage 1 [NCEP-1] diet) or a diet rich in monounsaturated fat (such as that common in Mediterranean countries).
Design:
Intervention dietary study with a baseline phase and two randomized crossover dietary periods.
Setting:
Hospital Universitario Reina Sofía, Córdoba, Spain.
Patients:
22 hypercholesterolemic men.
Intervention:
Patients followed a diet high in saturated fat, then were assigned in a crossover design to the NCEP-1 diet or a Mediterranean diet. Each dietary period lasted 28 days.
Measurements:
Plasma P-selectin levels, lipid concentrations, and endothelial function.
Results:
Compared with the saturated fat diet, flow-mediated dilatation increased during the Mediterranean diet but not during the NCEP-1 diet. In addition, levels of plasma cholesterol, low-density lipoprotein cholesterol, apolipoprotein B, and P-selectin decreased during the NCEP-1 and Mediterranean diets.
Conclusion:
In hypercholesterolemic men, diets low in fat (especially saturated fat) and diets rich in monounsaturated fats improve endothelial function.
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Information & Authors
Information
Published In
Annals of Internal Medicine
Volume 134 • Number 12 • 19 June 2001
Pages: 1115 - 1119
History
Published online: 19 June 2001
Published in issue: 19 June 2001
Keywords
- Apolipoproteins
- Arteries
- Biochemistry
- Blood
- Blood plasma
- Blood vessels
- Body fluids
- Cardiology and cardiovascular diseases
- Cardiovascular anatomy
- Cholesterol
- Diet
- Lipids
- Lipoproteins
- Nutrition
- Pathology and laboratory medicine
- Prevention, policy, and public health
- Proteins
- Research and reporting methods
- Vascular diseases
- Vascular medicine
Copyright
© 2001 American College of Physicians.
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Mediterranean and Low-Fat Diets Improve Endothelial Function in Hypercholesterolemic Men. Ann Intern Med.2001;134:1115-1119. [Epub 19 June 2001]. doi:10.7326/0003-4819-134-12-200106190-00011
Mediterranean and Low-Fat Diets Improve Endothelial Function in Hypercholesterolemic Men. Ann Intern Med.2001;134:1115-1119. [Epub 19 June 2001]. doi:10.7326/0003-4819-134-12-200106190-00011
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