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Abstract
Purpose
Identify subgroups of patients with distinct joint anxiety AND depression profiles and evaluate for differences in demographic and clinical characteristics, as well as stress, resilience, and coping.
Design
Longitudinal study
Participants
Patients (n = 1328) receiving chemotherapy.
Methods
Measures of state anxiety and depression were done six times over two cycles of chemotherapy. All of the other measures were completed prior to second or third cycle of chemotherapy. Latent profile analysis was used to identify the distinct joint anxiety and depression profiles.
Findings
Three classes were identified (i.e. Low Anxiety and Low Depression (57.5%); Moderate Anxiety and Moderate Depression (33.7%), High Anxiety and High Depression (8.8%)). For all of the stress measures, a dose response effect was seen among the profiles. Two worst profiles reported higher occurrence rates for a number of adverse childhood experiences.
Implications for providers
Patients need referrals for stress reduction techniques and mental health and social services.
Authors’ contributions
KC and CM conceptualized and designed the study with contributions from all of the other coauthors. BAC and SMP conducted the statistical analyses. KC and CM wrote the first draft of the manuscript. All of the other coauthors contributed to later draft. All of the authors read and approved the final version of the manuscript.
Disclosure statement
The authors have no conflicts of interest to disclose.
Data availability statement
The data that support the findings from this study are available from the corresponding author following review and completion of a data sharing agreement.