Abstract
Nonsteroidal antiinflammatory drugs (NSAIDs) are widely prescribed drugs that can result in gastroduodenal ulceration. Adverse effects upon the small and large intestine are now more often recognized. Small intestinal obstruction secondary to both mucosal diaphragms and broad-based stenoses is reported, but colonic strictures appear to be less common. A case of NSAID-induced colonic stricture leading to large bowel obstruction and secondary cecal perforation (previously unreported) is presented. Twelve additional cases of NSAID-induced colonic stricture are reviewed from the literature and its possible pathogenesis is discussed.
MeSH terms
- Acetaminophen / adverse effects
- Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
- Aspirin / adverse effects
- Colon / drug effects
- Colon / pathology
- Colon / surgery
- Colonic Diseases / chemically induced*
- Colonic Diseases / pathology
- Colonic Diseases / surgery
- Delayed-Action Preparations
- Dextropropoxyphene / adverse effects
- Diclofenac / adverse effects
- Drug Combinations
- Drug Therapy, Combination
- Emergencies
- Female
- Humans
- Intestinal Obstruction / chemically induced*
- Intestinal Obstruction / pathology
- Intestinal Obstruction / surgery
- Intestinal Perforation / chemically induced*
- Intestinal Perforation / pathology
- Intestinal Perforation / surgery
- Middle Aged
- Ranitidine / adverse effects
Substances
- Anti-Inflammatory Agents, Non-Steroidal
- Delayed-Action Preparations
- Drug Combinations
- Diclofenac
- Acetaminophen
- acetaminophen, dextropropoxyphene, drug combination
- Ranitidine
- Aspirin
- Dextropropoxyphene