Three-tiered EGFr domain risk stratification for individualized NOTCH3-small vessel disease prediction.
Hack RJ, Gravesteijn G, Cerfontaine MN, Santcroos MA, Gatti L, Kopczak A, Bersano A, Duering M, Rutten JW, Lesnik Oberstein SAJ. Hack RJ, et al. Brain. 2023 Jul 3;146(7):2913-2927. doi: 10.1093/brain/awac486. Brain. 2023. PMID: 36535904 Free PMC article.
In the CADASIL genotype-phenotype data set, HR-EGFr domains 8, 11 and 26 patients had a significantly higher risk of stroke (P = 0.002), disability (P = 0.041), nWMHv (P = 1.8 10-8), PSMD (P = 2.6 10-8) and lacune volume (P = 0.006) than MR-EGFr …
In the CADASIL genotype-phenotype data set, HR-EGFr domains 8, 11 and 26 patients had a significantly higher risk of stroke (P = 0.00 …