Diaminodiacid-Based Solid-Phase Synthesis of Peptide Disulfide Bond Mimics†
Hong-Kui Cui
Bayer-Tsinghua University Joint Research Center for Innovative Drug Discovery, Department of Chemistry, Tsinghua University, Beijing 100084 (China)
These authors contributed equally to this work.
Search for more papers by this authorYe Guo
Bayer-Tsinghua University Joint Research Center for Innovative Drug Discovery, Department of Chemistry, Tsinghua University, Beijing 100084 (China)
These authors contributed equally to this work.
Search for more papers by this authorYao He
School of Life Sciences, University of Science and Technology of China, High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei 230031 (China)
These authors contributed equally to this work.
Search for more papers by this authorFeng-Liang Wang
Bayer-Tsinghua University Joint Research Center for Innovative Drug Discovery, Department of Chemistry, Tsinghua University, Beijing 100084 (China)
Search for more papers by this authorHao-Nan Chang
Bayer-Tsinghua University Joint Research Center for Innovative Drug Discovery, Department of Chemistry, Tsinghua University, Beijing 100084 (China)
Search for more papers by this authorYu-Jia Wang
Bayer-Tsinghua University Joint Research Center for Innovative Drug Discovery, Department of Chemistry, Tsinghua University, Beijing 100084 (China)
Search for more papers by this authorFang-Ming Wu
School of Life Sciences, University of Science and Technology of China, High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei 230031 (China)
Search for more papers by this authorCorresponding Author
Prof. Dr. Chang-Lin Tian
School of Life Sciences, University of Science and Technology of China, High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei 230031 (China)
Chang-Lin Tian, School of Life Sciences, University of Science and Technology of China, High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei 230031 (China)
Lei Liu, Bayer-Tsinghua University Joint Research Center for Innovative Drug Discovery, Department of Chemistry, Tsinghua University, Beijing 100084 (China)
Search for more papers by this authorCorresponding Author
Prof. Dr. Lei Liu
Bayer-Tsinghua University Joint Research Center for Innovative Drug Discovery, Department of Chemistry, Tsinghua University, Beijing 100084 (China)
Chang-Lin Tian, School of Life Sciences, University of Science and Technology of China, High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei 230031 (China)
Lei Liu, Bayer-Tsinghua University Joint Research Center for Innovative Drug Discovery, Department of Chemistry, Tsinghua University, Beijing 100084 (China)
Search for more papers by this authorHong-Kui Cui
Bayer-Tsinghua University Joint Research Center for Innovative Drug Discovery, Department of Chemistry, Tsinghua University, Beijing 100084 (China)
These authors contributed equally to this work.
Search for more papers by this authorYe Guo
Bayer-Tsinghua University Joint Research Center for Innovative Drug Discovery, Department of Chemistry, Tsinghua University, Beijing 100084 (China)
These authors contributed equally to this work.
Search for more papers by this authorYao He
School of Life Sciences, University of Science and Technology of China, High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei 230031 (China)
These authors contributed equally to this work.
Search for more papers by this authorFeng-Liang Wang
Bayer-Tsinghua University Joint Research Center for Innovative Drug Discovery, Department of Chemistry, Tsinghua University, Beijing 100084 (China)
Search for more papers by this authorHao-Nan Chang
Bayer-Tsinghua University Joint Research Center for Innovative Drug Discovery, Department of Chemistry, Tsinghua University, Beijing 100084 (China)
Search for more papers by this authorYu-Jia Wang
Bayer-Tsinghua University Joint Research Center for Innovative Drug Discovery, Department of Chemistry, Tsinghua University, Beijing 100084 (China)
Search for more papers by this authorFang-Ming Wu
School of Life Sciences, University of Science and Technology of China, High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei 230031 (China)
Search for more papers by this authorCorresponding Author
Prof. Dr. Chang-Lin Tian
School of Life Sciences, University of Science and Technology of China, High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei 230031 (China)
Chang-Lin Tian, School of Life Sciences, University of Science and Technology of China, High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei 230031 (China)
Lei Liu, Bayer-Tsinghua University Joint Research Center for Innovative Drug Discovery, Department of Chemistry, Tsinghua University, Beijing 100084 (China)
Search for more papers by this authorCorresponding Author
Prof. Dr. Lei Liu
Bayer-Tsinghua University Joint Research Center for Innovative Drug Discovery, Department of Chemistry, Tsinghua University, Beijing 100084 (China)
Chang-Lin Tian, School of Life Sciences, University of Science and Technology of China, High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei 230031 (China)
Lei Liu, Bayer-Tsinghua University Joint Research Center for Innovative Drug Discovery, Department of Chemistry, Tsinghua University, Beijing 100084 (China)
Search for more papers by this authorThis work was supported by the national “863” and “973” grants from the Ministry of Science and Technology (No. 2012AA02A700, 2011CB965300, 2011CB911104) and NSFC (No. 20932006, 91013007, 31170817). We also thank Bayer Schering Pharma for the financial support. We thank Prof. Jingren Zhang for the help in the bioassays.
Graphical Abstract
Das antimikrobielle Peptid Tachyplesin I wurde als Modell für die Titelstrategie verwendet, die zur Herstellung von peptidischen Makrocyclen mit doppeltem Disulfidersatz entwickelt wurde. Die Faltung und Aktivität der Analogen von Tachyplesin I variierten abhängig von den Disulfidsurrogaten. SPPS=Festphasenpeptidsynthese.
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