Journal of Medical Virology

Volume 45, Issue 1 p. 43-49

Article

Lack of augmenting effect of interferon-γ on dengue virus multiplication in human peripheral blood monocytes

Dr. Nopporn Sittisombut,

Corresponding Author

Dr. Nopporn Sittisombut

Department of Microbiology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand

Department of Microbiology, Faculty of Medicine, Chiang Mai University, 110 Suthep Street, Chiang Mai 50200, Thailand===Search for more papers by this author

Niwat Maneekarn,

Niwat Maneekarn

Department of Microbiology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand

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Kwanjai Viputtikul,

Kwanjai Viputtikul

Department of Microbiology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand

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Jiraporn Supawadee,

Jiraporn Supawadee

Department of Microbiology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand

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Amornrat Kanjanahaluethai,

Amornrat Kanjanahaluethai

Department of Medicine, Faculty of Medicine, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand

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Watchara Kasinrerk,

Watchara Kasinrerk

Department of Clinical Immunology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand

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Dr. Nopporn Sittisombut,

Corresponding Author

Dr. Nopporn Sittisombut

Department of Microbiology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand

Department of Microbiology, Faculty of Medicine, Chiang Mai University, 110 Suthep Street, Chiang Mai 50200, Thailand===Search for more papers by this author

Niwat Maneekarn,

Niwat Maneekarn

Department of Microbiology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand

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Kwanjai Viputtikul,

Kwanjai Viputtikul

Department of Microbiology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand

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Jiraporn Supawadee,

Jiraporn Supawadee

Department of Microbiology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand

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Amornrat Kanjanahaluethai,

Amornrat Kanjanahaluethai

Department of Medicine, Faculty of Medicine, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand

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Watchara Kasinrerk,

Watchara Kasinrerk

Department of Clinical Immunology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand

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First published: January 1995

https://doi.org/10.1002/jmv.1890450109

Citations: 20

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Abstract

The effect of interferon—γ (IFN-γ) on dengue virus multiplication in human peripheral blood mono-cytes was investigated. Enriched monocytes were treated with IFN-γ and then infected with dengue virus type 2 either directly or in the presence of optimal infection-enhancing levels of antibodies. Pretreatment of monocytes from dengue-immune donors with 100 IU/ml of IFN-γ caused 12- to 97-fold and 13- to 137-fold reduction of virus yields at 24 hr after infection in the absence and presence of an anti-flavivirus monoclonal antibody, respectively. IFN-γ also diminished virus yields when infection of monocytes from a donor who lacked anti-dengue antibody was enhanced 40-fold. The percentage of infected monocytes in IFN-γ-pretreated cultures was similarly reduced. Dominance of the antiviral effect of IFN-γ in monocytes is in contrast to an augmenting effect previously observed in the promonocytic cell line U937. © 1995 Wiley-Liss, Inc.

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Volume45, Issue1

January 1995

Pages 43-49

Lack of augmenting effect of interferon-γ on dengue virus multiplication in human peripheral blood monocytes

Abstract

References

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Lack of augmenting effect of interferon-γ on dengue virus multiplication in human peripheral blood monocytes

Abstract

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