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A Comparison of Senescence in Mouse and Human Cells

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Cellular Senescence and Tumor Suppression

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Abstract

Senescence is observed in both human and mouse cells, however, there are fundamental differences in how senescence is controlled between the two species. Human fibroblasts undergo replicative senescence as a result of telomere shortening. In contrast, mouse fibroblasts do not senesce when grown at a physiological oxygen concentration. In atmospheric oxygen, mouse cells enter a state that resembles senescence, but is independent of telomere shortening. In this chapter, we will discuss the characteristics of both human and mouse cellular senescence, and the differences in the signaling pathways that mediate senescence in these species. We will also discuss the studies of senescence in species beyond human and mouse. It is important to note that mice are not representative of all rodents, as some rodent species display telomere-mediated senescence. We will also discuss the evolution of replicative senescence and the data suggesting that telomere-mediated senescence evolves in large-bodied species to mitigate an increased risk of cancer conferred by the greater number of cells.

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Acknowledgments

We thank Michael Bozzella for comments on the manuscript. The work in authors’ laboratory is supported by grants from US National Institute of Aging, and the Ellison Medical Foundation.

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Authors and Affiliations

  1. Department of Biology, University of Rochester, 213 Hutchison Hall, River Campus, 270211, Rochester, NY, 14627-0211, USA

    Vera Gorbunova & Andrei Seluanov

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  1. Vera Gorbunova
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  2. Andrei Seluanov
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Correspondence to Vera Gorbunova .

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Editors and Affiliations

  1. Cancer Research UK, University of Glasgow, Switchback Road, Glasgow, G61 1BD, United Kingdom

    Peter D. Adams

  2. Dept. Molecular & Cell Biology &, Brown University, Ship Street 70, Providence, 02912, U.S.A.

    John M. Sedivy

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Gorbunova, V., Seluanov, A. (2010). A Comparison of Senescence in Mouse and Human Cells. In: Adams, P., Sedivy, J. (eds) Cellular Senescence and Tumor Suppression. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1075-2_7

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