Abstract
COVID-19 has affected over 280 million people globally, with over 240 million survivors. While the acute effects of COVID-19 are well understood, we are just beginning to understand the long-term effects of COVID-19, particularly as they relate to lung function and recovery. Persistent symptoms have been described as the post-acute sequelae of COVID-19 (PASC) and include short-term and long-term sequelae. Post-COVID-19 conditions can occur in patients who have had varying severity of illness during their acute infection. These include people who have had mild or even asymptomatic infections [1]. Post-COVID-19 conditions are referred to by a wide range of names, including long COVID, post-acute COVID-19, long-term effects of COVID-19, post-acute COVID syndrome, chronic COVID, long-haul COVID, and late sequelae, among others. Although standardized case definitions are still being developed, post-COVID-19 conditions can be considered a lack of return to a usual state of health following acute COVID-19 illness. The time frame for a post-COVID-19 condition is generally considered as 2–4 weeks following acute COVID-19 infection with incomplete resolution of symptoms or the emergence of new symptoms. Post-acute COVID-19 can be a multisystem condition. Around 10–35% of patients who have acute COVID-19 infection go on to develop long COVID symptoms [2]. The most common non-resolving symptoms are dyspnea, fatigue, malaise, cognitive impairment, cough, chest pain, palpitations, arthralgias, diarrhea, sleep difficulties, fever, light-headedness, continued anosmia, and mood changes. For hospitalized patients, the incidence of the post-COVID-19 syndrome may reach as high as 85% [2]. Post-COVID-19 sequelae can be highly debilitating and seriously impact occupational and social activities. It also will add significantly to the healthcare burden in addition to its consequences on mental health.
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References
Havervall S, Rosell A, Phillipson M, et al. Symptoms and functional impairment assessed 8 months after mild COVID-19 among health care workers. JAMA. 2021;325(19):2015–6. https://doi.org/10.1001/jama.2021.5612.
Pavli A, Theodoridou M, Maltezou HC. Post-COVID syndrome: incidence, clinical Spectrum, and challenges for primary healthcare professionals. Arch Med Res. 2021;6(52):575–81. SSN 0188-4409. https://doi.org/10.1016/j.arcmed.2021.03.010.
Marvisi M, Ferrozzi F, Balzarini L, et al. First report on clinical and radiological features of COVID-19 pneumonitis in a Caucasian population: factors predicting fibrotic evolution. Int J Infect Dis. 2020;99:485–8.
Karlsson AC, Humbert M, Buggert M. The known unknowns of T cell immunity to COVID. Sci Immunol. 2020;5(53):19.
Ehrenfeld M, Tincani A, Andreoli L, et al. Covid-19 and autoimmunity. Autoimmun Rev. 2020;19(8):102597.
Zuo Y, Estes SK, Ali RA, et al. Prothrombotic autoantibodies in serum from patients hospitalized with COVID-19. Sci Transl Med. 2020;12:eabd3876.
Soriano JB, Murthy S, Marshall JC, Relan P, Diaz JV, WHO Clinical Case Definition Working Group on Post-COVID-19 Condition. A clinical case definition of post-COVID-19 condition by a Delphi consensus. Lancet. Infectious diseases. 2021;S1473-3099(21):00703–9. https://doi.org/10.1016/S1473-3099(21)00703-9.
Halpin SJ, McIvor C, Whyatt G, Adams A, Harvey O, McLean L, Walshaw C, Kemp S, Corrado J, Singh R, Collins T, O'Connor RJ, Sivan M. Postdischarge symptoms and rehabilitation needs in survivors of COVID-19 infection: a cross-sectional evaluation. J Med Virol. 2021;93(2):1013–22. https://doi.org/10.1002/jmv.26368.
Writing Committee for the COMEBAC Study Group, Morin L, Savale L, Pham T, Colle R, Figueiredo S, Harrois A, Gasnier M, Lecoq AL, Meyrignac O, Noel N, Baudry E, Bellin MF, Beurnier A, Choucha W, Corruble E, Dortet L, Hardy-Leger I, Radiguer F, Sportouch S, et al. Four-month clinical status of a cohort of patients after hospitalization for COVID-19. JAMA. 2021;325(15):1525–34. https://doi.org/10.1001/jama.2021.3331.
Xiong Q, Xu M, Li J, Liu Y, Zhang J, Xu Y, Dong W. Clinical sequelae of COVID-19 survivors in Wuhan, China: a single-Centre longitudinal study. Clin Microbiol Infect. 2021;27(1):89–95. https://doi.org/10.1016/j.cmi.2020.09.023.
Carfì A, Bernabei R, Landi F, Gemelli Against COVID-19 Post-Acute Care Study Group. Persistent symptoms in patients after acute COVID-19. JAMA. 2020;324(6):603–5. https://doi.org/10.1001/jama.2020.12603.
Cares-Marambio K, Montenegro-Jiménez Y, Torres-Castro R, Vera-Uribe R, Torralba Y, Alsina-Restoy X, Vasconcello-Castillo L, Vilaró J. Prevalence of potential respiratory symptoms in survivors of hospital admission after coronavirus disease 2019 (COVID-19): a systematic review and meta-analysis. Chron Respir Dis. 2021;18:14799731211002240. https://doi.org/10.1177/14799731211002240.
Bellan M, Soddu D, Balbo PE, et al. Respiratory and psychophysical sequelae among patients with COVID-19 four months after hospital discharge. JAMA Netw Open. 2021;4(1):e2036142.
Han X, Fan Y, Alwalid O, et al. Six-month follow-up chest CT findings after severe COVID-19 pneumonia. Radiology. 2021;299(1):E177–86.
Zhao YM, Shang YM, Song WB, et al. Follow-up study of the pulmonary function and related physiological characteristics of COVID-19 survivors three months after recovery. E Clin Med. 2020;25:100463.
van den Borst B, et al. Comprehensive health assessment three months after recovery from acute COVID-19. Clin Infect Dis 2020;ciaa1750.
Huang C, Huang L, Wang Y, et al. 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study. Lancet. 2021;397(10270):220–32.
Swigris JJ, Streiner DL, Brown KK, et al. Assessing exertional dyspnea in patients with idiopathic pulmonary fibrosis. Respir Med. 2014;108(1):181–8.
Sollini M, et al. Vasculitis changes in COVID-19 survivors with persistent symptoms: an [(18)F]FDG-PET/CT study. Eur J Nucl Med Mol Imaging. 2020;48(5):1460–6.
Orme J Jr, Romney JS, Hopkins RO, Pope D, Chan KJ, Thomsen G, Crapo RO, Weaver LK. Pulmonary function and health-related quality of life in survivors of acute respiratory distress syndrome. Am J Respir Crit Care Med. 2003;167(5):690–4.
Marini JJ, Gattinoni L. Management of COVID-19 respiratory distress. JAMA. 2020;323(22):2329–30.
Hsieh MJ, Lee WC, Cho HY, Wu MF, Hu HC, Kao KC, Chen NH, Tsai YH, Huang CC. Recovery of pulmonary functions, exercise capacity, and quality of life after pulmonary rehabilitation in survivors of ARDS due to severe influenza a (H1N1) pneumonitis. Influenza Other Respir Viruses. 2018;12(5):643–8.
Liu W, Peng L, Liu H, Hua S. Pulmonary function and clinical manifestations of patients infected with mild influenza a virus subtype H1N1: a one-year follow-up. PLoS One. 2015;10(7):e0133698.
Ong KC, Ng AW, Lee LS, Kaw G, Kwek SK, Leow MK, Earnest A. 1-year pulmonary function and health status in survivors of severe acute respiratory syndrome. Chest. 2005;128(3):1393–400.
Fumagalli A, Misuraca C, Bianchi A, Borsa N, Limonta S, Maggiolini S, Bonardi DR, Corsonello A, Di Rosa M, Soraci L, Lattanzio F, Colombo D. Pulmonary function in patients surviving to COVID-19 pneumonia. Infection. 2021;49(1):153–7.
Huang Y, Tan C, Wu J, Chen M, Wang Z, Luo L, Zhou X, Liu X, Huang X, Yuan S, Chen C, Gao F, Huang J, Shan H, Liu J. Impact of coronavirus disease 2019 on pulmonary function in early convalescence phase. Respir Res. 2020;21(1):163.
Torres-Castro R, Vasconcello-Castillo L, Alsina-Restoy X, Solis-Navarro L, Burgos F, Puppo H, Vilaró J. Respiratory function in patients post-infection by COVID-19: a systematic review and meta-analysis. Pulmonology. 2021;27(4):328–37.
Groff D, Sun A, Ssentongo AE, Ba DM, Parsons N, Poudel GR, Lekoubou A, Oh JS, Ericson JE, Ssentongo P, Chinchilli VM. Short-term and long-term rates of Postacute sequelae of SARS-CoV-2 infection: a systematic review. JAMA Netw Open. 2021;4(10):e2128568.
Shah AS, Wong AW, Hague CJ, Murphy DT, Johnston JC, Ryerson CJ, Carlsten C. A prospective study of 12-week respiratory outcomes in COVID-19-related hospitalisations. Thorax. 2021;76(4):402–4.
Nalbandian A, Sehgal K, Gupta A, Madhavan MV, McGroder C, Stevens JS, Cook JR, Nordvig AS, Shalev D, Sehrawat TS, Ahluwalia N, Bikdeli B, Dietz D, Der-Nigoghossian C, Liyanage-Don N, Rosner GF, Bernstein EJ, Mohan S, Beckley AA, Seres DS, et al. Post-acute COVID-19 syndrome. Nat Med. 2021;27(4):601–15. https://doi.org/10.1038/s41591-021-01283-z.
Gibson P, Wang G, McGarvey L, et al. Treatment of unexplained chronic cough: CHEST guideline and expert panel report. Chest. 2016;149:27–44.
Ryan NM, Birring SS, Gibson PG. Gabapentin for refractory chronic cough: a randomised, double-blind, placebo-controlled trial. Lancet. 2012;380:1583–9.
Clemency BM, Varughese R, Gonzalez-Rojas Y, et al. Efficacy of inhaled Ciclesonide for outpatient treatment of adolescents and adults with symptomatic COVID-19: a randomized clinical trial. JAMA Intern Med. 2022;182(1):42–9. https://doi.org/10.1001/jamainternmed.2021.6759.
Raghu G, Wilson KC. COVID-19 interstitial pneumonia: monitoring the clinical course in survivors. Lancet Respir Med. 2020;8(9):839–42. https://doi.org/10.1016/S2213-2600(20)30349-0.
Myall KJ, Mukherjee B, Castanheira AM, Lam JL, Benedetti G, Mak SM, Preston R, Thillai M, Dewar A, Molyneaux PL, West AG. Persistent post-COVID-19 interstitial lung disease. An observational study of corticosteroid treatment. Ann Am Thorac Soc. 2021;18(5):799–806.
Dhooria S, Chaudhary S, Sehgal IS, Agarwal R, Arora S, Garg M, Prabhakar N, Puri GD, Bhalla A, Suri V, Yaddanapudi LN, Muthu V, Prasad KT, Aggarwal AN. High-dose versus low-dose prednisolone in symptomatic patients with post-COVID-19 diffuse parenchymal lung abnormalities: an open-label, randomised trial (acronym: COLDSTER). Eur Respir J. 2021;2102930. Advance online publication https://doi.org/10.1183/13993003.02930-2021.
Antonio GE, Wong KT, Hui DS, Wu A, Lee N, Yuen EH, Leung CB, Rainer TH, Cameron P, Chung SS, Sung JJ, Ahuja AT. Thin-section CT in patients with severe acute respiratory syndrome following hospital discharge: preliminary experience. Radiology. 2003;228(3):810–5.
George PM, Wells AU, Jenkins RG. Pulmonary fibrosis and COVID-19: the potential role for antifibrotic therapy. Lancet Respir Med. 2020;8(8):807–15.
Gloeckl R, Leitl D, Jarosch I, Schneeberger T, Nell C, Stenzel N, Vogelmeier CF, Kenn K, Koczulla AR. Benefits of pulmonary rehabilitation in COVID-19: a prospective observational cohort study. ERJ Open Res. 2021;7(2):00108–2021. https://doi.org/10.1183/23120541.00108-2021.
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Hasan, Z., Agrawal, A., Narasimhan, M. (2022). Pulmonary Sequelae of COVID-19. In: Mohan, A., Mittal, S. (eds) Post COVID-19 Complications and Management. Springer, Singapore. https://doi.org/10.1007/978-981-19-4407-9_2
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