Abstract
There is an inconsistent finding about the relationship of catechol-O-methyltransferase (COMT) with dementia susceptibility, as well as with cognitive impairment. To substantiate this, we examined COMT genotype effects in certain cognitive domains in dementia. To evaluate the effects of COMT Val158Met on cognitive performance, we used The Mini-Mental State Examination (MMSE), the cognitive subscale of the Alzheimer’s Disease Assessment Scale-cognitive (ADAS-cog) and the Syndrome Kurz Test (SKT). The results show COMT Val/Met, Val/Val genotype polymorphisms had a significant effect on cognition performance (OR = 1.75 (95 %CI 1.22–2.54) and (OR = 2.76 (95 %CI 1.78–4.26), p < 0.001), and with adjustment for all cognitive test scores together, Val/Val (OR = 4.98 (95 % CI 1.47–16.86) and Val/Met (OR = 3.62 (95 % CI 1.37–9.56) had effect. Our study allows us to understand the role of COMT in cognitive performance in dementia, as well as interaction with other known risk factors for this pathology. This data might help in developing new therapeutic targets for cognitive impairment, main symptom of dementia. Other risk genotypes or haplotypes should be evaluated to determine the association with cognitive decline in dementia.
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Data availability
The data used for this study are available upon request to the corresponding author.
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Acknowledgements
Authors thank Valle Medina Antonio, for his valuable participation in capturing the genetic information used in this study, and Ms. Susan Drier-Jonas for her help with the manuscript.
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This study was funded by grants from SSA/IMSS/ISSSTE-CONACYT (Mexico) SALUD- 233065.
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TJC: main investigator, idea of the study, participated in coordination, and drafted the manuscript. EGF: analyzed and interpreted the cognitive tests the patients and coordinate the study. NMR: participated in the coordination and drafted the manuscript. JMF: participated in its design and coordination and drafted the manuscript. OGA: participated in its design and coordination. GVA: participated in genetic analysis and drafted the manuscript. All authors read and approved the final manuscript.
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Juárez-Cedillo, T., González-Figueroa, E., Martínez-Rodríguez, N. et al. Influence of COMT polymorphism in cognitive performance on dementia in community-dwelling elderly Mexican (SADEM study). Metab Brain Dis 36, 1223–1229 (2021). https://doi.org/10.1007/s11011-021-00740-5
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DOI: https://doi.org/10.1007/s11011-021-00740-5