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Lipid Membrane Deformation Accompanied by Disk-to-Ring Shape Transition of Cholesterol-Rich Domains

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† ‡ †Departments of Electrical and Computer Engineering and ‡Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota 55455, United States
§ School of Electrical Engineering, Seoul National University, Seoul, Republic of Korea 151-742
∥ Departments of Biomedical Engineering and Chemical Engineering & Materials Science, University of California, Davis, California 95616, United States
*[email protected]
Cite this: J. Am. Chem. Soc. 2015, 137, 27, 8692–8695
Publication Date (Web):June 8, 2015
https://doi.org/10.1021/jacs.5b04559
Copyright © 2015 American Chemical Society
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    Abstract

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    During vesicle budding or endocytosis, biomembranes undergo a series of lipid- and protein-mediated deformations involving cholesterol-enriched lipid rafts. If lipid rafts of high bending rigidities become confined to the incipient curved membrane topology such as a bud-neck interface, they can be expected to reform as ring-shaped rafts. Here, we report on the observation of a disk-to-ring shape morpho-chemical transition of a model membrane in the absence of geometric constraints. The raft shape transition is triggered by lateral compositional heterogeneity and is accompanied by membrane deformation in the vertical direction, which is detected by height-sensitive fluorescence interference contrast microscopy. Our results suggest that a flat membrane can become curved simply by dynamic changes in local chemical composition and shape transformation of cholesterol-rich domains.

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    Details on sample fabrication, lipid membrane preparation, FLIC microscopy, and deformation energy calculation. The Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/jacs.5b04559.

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