https://orcid.org/0000-0002-3688-8545
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Abstract
Objective
This study examined the unique associations of different dimensions of the resilience factor, benefit finding, on concurrent and prospective psychological and biological adjustment outcomes over the first year after a colorectal cancer diagnosis.
Methods and measures
Individuals newly diagnosed with colorectal cancer (n = 133, mean age = 56 years old, 59% female, 46% Hispanic) completed questionnaires assessing the multidimensional aspects of benefit finding around 4 months post-diagnosis (T1). Psychological (depressive symptoms and life satisfaction) and biological [C-reactive protein (CRP) and interleukin-10 (IL-10)] adjustments were assessed at T1 and one-year post-diagnosis (T2).
Results
Structural equation modeling revealed that at T1, greater reprioritization was concurrently related to higher depressive symptoms (p=.020). Lower acceptance, lower empathy, and greater positive self-view predicted higher life satisfaction at T2 (ps<.010). Additionally, lower empathy and greater family valuation predicted higher CRP at T2 (ps<.004), whereas greater positive self-view predicted higher IL-10 at T2 (p=.039). Greater overall benefit finding was associated with lower IL-10 at T1 (p=.013).
Conclusion
Various aspects of benefit finding differentially relate to psychological and inflammatory markers during the first year after diagnosis in persons with colorectal cancer. Interventions designed to specifically enhance positive self-view may promote both the psychological and biological health of individuals with cancer.
Authors’ contributions
TCT contributed to data analysis and writing and reviewing of the manuscript. GGL contributed to writing and reviewing the manuscript. AT contributed to data collection and analysis. MH contributed to reviewing of the manuscript. AM contributed to biological data processing and reviewing of the manuscript. CSC contributed to the conceptualization of the research goals and aims. YK developed the study concept, contributed to the conceptualization of the research goals and aims, acquired funding, data collection and analysis, and writing and reviewing of the manuscript.
Data availability statement
This study and its analysis plan was not formally registered. De-identified data and analytic code used to conduct this study are not available in a public archive but can be provided upon request. Materials used to conduct this study are not publicly available.