Lipid Rafts and Caveolae and Their Role in Compartmentation of Redox Signaling
Publication: Antioxidants & Redox Signaling
Volume 11, Issue Number 6
Abstract
Membrane (lipid) rafts and caveolae, a subset of rafts, are cellular domains that concentrate plasma membrane proteins and lipids involved in the regulation of cell function. In addition to providing signaling platforms for G-protein-coupled receptors and certain tyrosine kinase receptors, rafts/caveolae can influence redox signaling. This review discusses molecular characteristics of and methods to study rafts/caveolae, determinants that contribute to the localization of molecules in these entities, an overview of signaling molecules that show such localization, and the contribution of rafts/caveolae to redox signaling. Of particular note is the evidence that endothelial nitric oxide synthase (eNOS), NADPH oxygenase, and heme oxygenase, along with other less well-studied redox systems, localize in rafts and caveolae. The precise basis for this localization and the contribution of raft/caveolae-localized redox components to physiology and disease are important issues for future studies. Antioxid. Redox Signal. 11, 1357–1372.
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Published In
Antioxidants & Redox Signaling
Volume 11 • Issue Number 6 • June 2009
Pages: 1357 - 1372
PubMed: 19061440
Copyright
Copyright 2009, Mary Ann Liebert, Inc.
History
Published in print: June 2009
Published online: 21 April 2009
Published ahead of print: 18 March 2009
Published ahead of production: 8 December 2008
Accepted: 6 December 2008
Received: 19 November 2008
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