From the ^∗D'Or Institute for Research and Education, Rio de Janeiro, Brazil

^†Department of Radiology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil

^‡Laboratory of Pulmonary Engineering, Biomedical Engineering Program, Alberto Luiz Coimbra Institute of Post-Graduation and Research in Engineering, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil

^§Laboratory of Respiration Physiology, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro

^∥Laboratory of Immunopharmacology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro

^¶Laboratory of Immunothrombosis, Department of Biochemistry, Federal University of Juiz de Fora (UFJF), Juiz de Fora, Minas Gerais

^∗∗National Institute of Infectious Disease Evandro Chagas, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil

^††Cardiovascular R&D Centre (UnIC), Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Porto, Portugal.

Received for publication May 5, 2022; revision accepted July 1, 2022.

Conflicts of interest and sources of funding: The authors declare that they have no conflicts of interest. This work was supported by grants from the D'Or Institute for Research and Education, Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (numbers E-26/202.751/2018, E-26/202.785/2017, E-26/203.001/2018, E-26/203.279/2017, and E-26/211.867/2016), and Conselho Nacional de Desenvolvimento Científico e Tecnológico (numbers 02839/2017-8, 302702/2017-2, and 312410/2017-4).

Author Contributions: R.S.R., P.H.R.d.C., G.M.R., F.A.B., and M.M.B. wrote the manuscript; J.d.T.-M. and P.A.G.M. contributed to patient recruitment and management; R.M.-G. and E.D.H. performed sample processing, flow cytometry, and enzyme-linked immunosorbent assays; G.M.R., A.R.C, and R.B. performed the computational imaging and statistical analyses; M.M.B. performed the visual CT analysis; S.A.d.A. contributed to PET/CT acquisition and analysis; R.S.R., P.H.R.d.C., F.A.B., W.A.Z., and P.T.B. are responsible for the experimental design, manuscript review, and study supervision. All authors reviewed the final manuscript.

Correspondence to: Rosana Souza Rodrigues, MD, PhD, D'Or Institute for Research and Education. Rua Diniz Cordeiro 30, Botafogo, Rio de Janeiro/RJ, Brazil 22281-100. E-mail: [email protected].