Loneliness predicts physical and mental health-related quality of life over 9 months among patients with coronary heart disease
Yunge Fan
Psychology Programme, School of Social Sciences, Nanyang Technological University, Singapore
Search for more papers by this authorCorresponding Author
Moon-Ho Ringo Ho
Psychology Programme, School of Social Sciences, Nanyang Technological University, Singapore
Correspondence
Ho Moon-Ho Ringo, Psychology Programme, School of Social Sciences, Nanyang Technological University, 48 Nanyang Avenue. Singapore 639818.
Email: [email protected]
Search for more papers by this authorBiing-Jiun Shen
The Wright Institute, Berkeley, California, USA
Search for more papers by this authorYunge Fan
Psychology Programme, School of Social Sciences, Nanyang Technological University, Singapore
Search for more papers by this authorCorresponding Author
Moon-Ho Ringo Ho
Psychology Programme, School of Social Sciences, Nanyang Technological University, Singapore
Correspondence
Ho Moon-Ho Ringo, Psychology Programme, School of Social Sciences, Nanyang Technological University, 48 Nanyang Avenue. Singapore 639818.
Email: [email protected]
Search for more papers by this authorBiing-Jiun Shen
The Wright Institute, Berkeley, California, USA
Search for more papers by this authorFunding information:
This study was supported by the Singapore Ministry of Education Academic Research Fund Tier 1 Grant (RG60/14) and a STAUG award from Nanyang Technological University.
Abstract
This study investigated whether loneliness would predict physical and mental health-related quality of life (HRQoL) over 9 months and examined whether medical adherence would mediate their associations in patients with coronary heart disease (CHD). The overall design is a three-wave longitudinal study. A sample of 255 outpatients with CHD was recruited from a community-based cardiac rehabilitation programme. Participants, with a mean age of 63 years, completed measures assessing loneliness, depression and physical and mental HRQoL at baseline. Medical adherence was assessed at 3 months, and physical and mental HRQoL were reassessed at 9 months. A total of 88% of participants reported moderate or high loneliness. Baseline loneliness predicted physical and mental HRQoL at 9 months after adjusting for baseline physical and mental HRQoL, respectively. The effects remained significant when depression was also adjusted. Medical adherence at 3 months partially mediated the associations of baseline loneliness with 9-month physical and mental HRQoL. Findings underline the necessity of assessing loneliness for CHD patients to promote long-term medical adherence and further improve physical and mental HRQoL.
Supporting Information
Filename | Description |
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aphw12403-sup-0001-3 Revision Supplementary material.docxWord 2007 document , 146 KB | Supplementary Table S1. Bivariate correlations for relevant demographic, medical, and study variables Figure S1. Numbers of participants who returned for follow-ups and those who did not with reasons for attrition at 3 and 9 months |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
REFERENCES
- American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (DSM-5®). American psychiatric pub.
10.1176/appi.books.9780890425596 Google Scholar
- Aylaz, R., Akturk, U., Erci, B., Ozturk, H., & Aslan, H. (2012). Relationship between depression and loneliness in elderly and examination of influential factors. Archives of Gerontology and Geriatrics, 55(3), 548–554. https://doi.org/10.1016/j.archger.2012.03.006
- Bandari, R., Khankeh, H. R., Shahboulaghi, F. M., Ebadi, A., Keshtkar, A. A., & Montazeri, A. (2019). Defining loneliness in older adults: Protocol for a systematic review. Systematic Reviews, 8(1), 26. https://doi.org/10.1186/s13643-018-0935-y
- Beller, J. (2022). Loneliness and mortality: The moderating effect of positive affect. Applied Psychology. Health and Well-Being. https://doi.org/10.1111/aphw.12354
- Berkman, L. F., Kawachi, I., & Glymour, M. M. (2014). Social epidemiology. Oxford University Press. https://doi.org/10.1093/med/9780195377903.001.0001
10.1093/med/9780195377903.001.0001 Google Scholar
- Cacioppo, J. T., & Hawkley, L. C. (2009). Perceived social isolation and cognition. Trends in Cognitive Sciences, 13(10), 447–454. https://doi.org/10.1016/j.tics.2009.06.005
- Cacioppo, J. T., & Patrick, W. (2008). Loneliness: Human nature and the need for social connection. WW Norton & Company.
- Chowdhury, R., Khan, H., Heydon, E., Shroufi, A., Fahimi, S., Moore, C., Stricker, B., Mendis, S., Hofman, A., Mant, J., & Franco, O. H. (2013). Adherence to cardiovascular therapy: A meta-analysis of prevalence and clinical consequences. European Heart Journal, 34(38), 2940–2948. https://doi.org/10.1093/eurheartj/eht295
- Christensen, A. V., Juel, K., Ekholm, O., Thrysoe, L., Thorup, C. B., Borregaard, B., Mols, R. E., Rasmussen, T. B., & Berg, S. K. (2020). Significantly increased risk of all-cause mortality among cardiac patients feeling lonely. Heart, 106(2), 140–146. https://doi.org/10.1136/heartjnl-2019-315460
- Dickens, C., Cherrington, A., & McGowan, L. (2012). Depression and health-related quality of life in people with coronary heart disease: A systematic review. European Journal of Cardiovascular Nursing, 11(3), 265–275. https://doi.org/10.1177/1474515111430928
- DiMatteo, M. R., Sherbourne, C. D., Hays, R. D., Ordway, L., Kravitz, R. L., McGlynn, E. A., Kaplan, S., & Rogers, W. H. (1993). Physicians' characteristics influence patients' adherence to medical treatment: Results from the medical outcomes study. Health Psychology, 12(2), 93–102. https://www.ncbi.nlm.nih.gov/pubmed/8500445, https://doi.org/10.1037/0278-6133.12.2.93
- Fayed, A., AlRadini, F., Alzuhairi, R. M., Aljuhani, A. E., Alrashid, H. R., Alwazae, M. M., & Alghamdi, N. R. (2022). Relation between diabetes related distress and glycemic control: The mediating effect of adherence to treatment. Primary Care Diabetes, 16(2), 293–300. https://doi.org/10.1016/j.pcd.2021.12.004
- Franco, D. W., Alessi, J., Becker, A. S., do Amaral, B. B., de Oliveira, G. B., Schaan, B. D., & Telo, G. H. (2021). Medical adherence in the time of social distancing: A brief report on the impact of the COVID-19 pandemic on adherence to treatment in patients with diabetes. Archives of Endocrinology and Metabolism, 65(4), 517–521. https://doi.org/10.20945/2359-3997000000362
- Global Health Estimates 2016. (2018). Deaths by cause, Age, Sex, by Country and by Region, 2000–2016. http://www.who.int/healthinfo/global_burden_disease/estimates/en/index1.html
- Hawkley, L. C., & Cacioppo, J. T. (2010). Loneliness matters: A theoretical and empirical review of consequences and mechanisms. Annals of Behavioral Medicine, 40(2), 218–227. https://doi.org/10.1007/s12160-010-9210-8
- Hayes, A. F. (2009). Beyond Baron and Kenny: Statistical mediation analysis in the new millennium. Communication Monographs, 76(4), 408–420. https://doi.org/10.1080/03637750903310360
- Hiller, A., Helvik, A. S., Kaasa, S., & Slordahl, S. A. (2010). Psychometric properties of the Norwegian MacNew heart disease health-related quality of life inventory. European Journal of Cardiovascular Nursing, 9(3), 146–152. https://doi.org/10.1016/j.ejcnurse.2010.01.002
- Holmes, E. A., O'Connor, R. C., Perry, V. H., Tracey, I., Wessely, S., Arseneault, L., Ballard, C., Christensen, H., Cohen Silver, R., Everall, I., Ford, T., John, A., Kabir, T., King, K., Madan, I., Michie, S., Przybylski, A. K., Shafran, R., Sweeney, A., … Bullmore, E. (2020). Multidisciplinary research priorities for the COVID-19 pandemic: A call for action for mental health science. Lancet Psychiatry, 7(6), 547–560. https://doi.org/10.1016/S2215-0366(20)30168-1
- Holt-Lunstad, J., Smith, T. B., Baker, M., Harris, T., & Stephenson, D. (2015). Loneliness and social isolation as risk factors for mortality: A meta-analytic review. Perspectives on Psychological Science, 10(2), 227–237. https://doi.org/10.1177/1745691614568352
- Keles, H., Ekici, A., Ekici, M., Bulcun, E., & Altinkaya, V. (2007). Effect of chronic diseases and associated psychological distress on health-related quality of life. Internal Medicine Journal, 37(1), 6–11. https://doi.org/10.1111/j.1445-5994.2006.01215.x
- Le, J., Dorstyn, D. S., Mpofu, E., Prior, E., & Tully, P. J. (2018). Health-related quality of life in coronary heart disease: A systematic review and meta-analysis mapped against the international classification of functioning, disability and health. Quality of Life Research, 27(10), 2491–2503. https://doi.org/10.1007/s11136-018-1885-5
- Lee, E. E., Depp, C., Palmer, B. W., Glorioso, D., Daly, R., Liu, J., Tu, X. M., Kim, H. C., Tarr, P., Yamada, Y., & Jeste, D. V. (2019). High prevalence and adverse health effects of loneliness in community-dwelling adults across the lifespan: Role of wisdom as a protective factor. International Psychogeriatrics, 31(10), 1447–1462. https://doi.org/10.1017/S1041610218002120
- Lippke, S., Fischer, M. A., & Ratz, T. (2021). Physical activity, loneliness, and meaning of friendship in young individuals - a mixed-methods investigation Prior to and during the COVID-19 pandemic with three cross-sectional studies. Frontiers in Psychology, 12, 617267. https://doi.org/10.3389/fpsyg.2021.617267
- Lu, J., Zhang, N., Mao, D., Wang, Y., & Wang, X. (2020). How social isolation and loneliness effect medication adherence among elderly with chronic diseases: An integrated theory and validated cross-sectional study. Archives of Gerontology and Geriatrics, 90, 104154. https://doi.org/10.1016/j.archger.2020.104154
- Maeda, U., Shen, B. J., Schwarz, E. R., Farrell, K. A., & Mallon, S. (2013). Self-efficacy mediates the associations of social support and depression with treatment adherence in heart failure patients. International Journal of Behavioral Medicine, 20(1), 88–96. https://doi.org/10.1007/s12529-011-9215-0
- Martin-Maria, N., Caballero, F. F., Lara, E., Domenech-Abella, J., Haro, J. M., Olaya, B., Ayuso-Mateos, J. L., & Miret, M. (2020). Effects of transient and chronic loneliness on major depression in older adults: A longitudinal study. International Journal of Geriatric Psychiatry, 36(1), 76–85. https://doi.org/10.1002/gps.5397
- Oksuz, E., Cinar, F. I., Cinar, M., Tekgoz, E., & Yilmaz, S. (2020). Assessment of the effects of loneliness, perceived social support, and depression on medication adherence in patients with ankylosing spondylitis. Perspectives in Psychiatric Care, 52(2), 517–523. https://doi.org/10.1111/ppc.12570
- Paul, C., Ayis, S., & Ebrahim, S. (2006). Psychological distress, loneliness and disability in old age. Psychology, Health & Medicine, 11(2), 221–232. https://doi.org/10.1080/13548500500262945
- Pragodpol, P., & Ryan, C. (2013). Critical review of factors predicting health-related quality of life in newly diagnosed coronary artery disease patients. Journal of Cardiovascular Nursing, 28(3), 277–284. https://doi.org/10.1097/JCN.0b013e31824af56e
- Preacher, K. J., & Hayes, A. F. (2008). Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models. Behavior Research Methods, 40(3), 879–891. https://doi.org/10.3758/brm.40.3.879
- Radloff, L. S. (1977). The CES-D scale: A self-report depression scale for research in the general population. Applied Psychological Measurement, 1(3), 385–401. https://doi.org/10.1177/014662167700100306
10.1177/014662167700100306 Google Scholar
- Radloff, L. S., & Locke, B. Z. (1986). The community mental health assessment survey and the CES-D scale. Community Surveys of Psychiatric Disorders, 4, 177–188.
- Rico-Uribe, L. A., Caballero, F. F., Martin-Maria, N., Cabello, M., Ayuso-Mateos, J. L., & Miret, M. (2018). Association of loneliness with all-cause mortality: A meta-analysis. PLoS ONE, 13(1), e0190033. https://doi.org/10.1371/journal.pone.0190033
- Russell, D. W. (1996). UCLA loneliness scale (version 3): Reliability, validity, and factor structure. Journal of Personality Assessment, 66(1), 20–40. https://doi.org/10.1207/s15327752jpa6601_2
- Sajobi, T. T., Wang, M., Awosoga, O., Santana, M., Southern, D., Liang, Z., Galbraith, D., Wilton, S. B., Quan, H., Graham, M. M., James, M. T., Ghali, W. A., Knudtson, M. L., Norris, C., & Investigators, A. (2018). Trajectories of health-related quality of life in coronary artery disease. Circulation. Cardiovascular Quality and Outcomes, 11(3), e003661. https://doi.org/10.1161/CIRCOUTCOMES.117.003661
- Savikko, N., Routasalo, P., Tilvis, R. S., Strandberg, T. E., & Pitkala, K. H. (2005). Predictors and subjective causes of loneliness in an aged population. Archives of Gerontology and Geriatrics, 41(3), 223–233. https://doi.org/10.1016/j.archger.2005.03.002
- Shen, B. J., Fan, Y., Lim, K. S. C., & Tay, H. Y. (2019). Depression, anxiety, perceived stress, and their changes predict greater decline in physical health functioning over 12 months among patients with coronary heart disease. International Journal of Behavioral Medicine, 26(4), 352–364. https://doi.org/10.1007/s12529-019-09794-3
- Sherbourne, C. D., Hays, R. D., Ordway, L., DiMatteo, M. R., & Kravitz, R. L. (1992). Antecedents of adherence to medical recommendations: Results from the medical outcomes study. Journal of Behavioral Medicine, 15(5), 447–468. https://www.ncbi.nlm.nih.gov/pubmed/1447757, https://doi.org/10.1007/BF00844941
- Smith, S. C. Jr., Benjamin, E. J., Bonow, R. O., Braun, L. T., Creager, M. A., Franklin, B. A., Gibbons, R. J., Grundy, S. M., Hiratzka, L. F., Jones, D. W., Lloyd-Jones, D. M., Minissian, M., Mosca, L., Peterson, E. D., Sacco, R. L., Spertus, J., Stein, J. H., Taubert, K. A., World Heart, F, & the Preventive Cardiovascular Nurses, A. (2011). AHA/ACCF secondary prevention and risk reduction therapy for patients with coronary and other atherosclerotic vascular disease: 2011 update: A guideline from the American Heart Association and American College of Cardiology Foundation. Circulation, 124(22), 2458–2473. https://doi.org/10.1161/CIR.0b013e318235eb4d
- Sun, P., Xing, L., Wu, J., & Kou, Y. (2022). Receiving feedback after posting status updates on social networking sites predicts lower loneliness: A mediated moderation model. Applied Psychology. Health and Well-Being. https://doi.org/10.1111/aphw.12378
- Tabue Teguo, M., Simo-Tabue, N., Stoykova, R., Meillon, C., Cogne, M., Amieva, H., & Dartigues, J. F. (2016). Feelings of loneliness and living alone as predictors of mortality in the elderly: The PAQUID study. Psychosomatic Medicine, 78(8), 904–909. https://doi.org/10.1097/PSY.0000000000000386
- Tan, S. S., Fierloos, I. N., Zhang, X., Koppelaar, E., Alhambra-Borras, T., Rentoumis, T., Williams, G., Rukavina, T., van Staveren, R., Garces-Ferrer, J., Franse, C. B., & Raat, H. (2020). The association between loneliness and health related quality of life (HR-QoL) among community-dwelling older citizens. International Journal of Environmental Research and Public Health, 17(2), 600. https://doi.org/10.3390/ijerph17020600
- Valenti, L., Lim, L., Heller, R. F., & Knapp, J. (1996). An improved questionnaire for assessing quality of life after acute myocardial infarction. Quality of Life Research, 5(1), 151–161. https://doi.org/10.1007/BF00435980
- Valtorta, N. K., Kanaan, M., Gilbody, S., & Hanratty, B. (2018). Loneliness, social isolation and risk of cardiovascular disease in the English longitudinal study of ageing. European Journal of Preventive Cardiology, 25(13), 1387–1396. https://doi.org/10.1177/2047487318792696
- Valtorta, N. K., Kanaan, M., Gilbody, S., Ronzi, S., & Hanratty, B. (2016). Loneliness and social isolation as risk factors for coronary heart disease and stroke: Systematic review and meta-analysis of longitudinal observational studies. Heart, 102(13), 1009–1016. https://doi.org/10.1136/heartjnl-2015-308790
- Victor, C. R., & Yang, K. (2012). The prevalence of loneliness among adults: A case study of the United Kingdom. Journal of Psychology, 146(1–2), 85–104. https://doi.org/10.1080/00223980.2011.613875
- Whooley, M. A., de Jonge, P., Vittinghoff, E., Otte, C., Moos, R., Carney, R. M., Ali, S., Dowray, S., Na, B., Feldman, M. D., Schiller, N. B., & Browner, W. S. (2008). Depressive symptoms, health behaviors, and risk of cardiovascular events in patients with coronary heart disease. JAMA, 300(20), 2379–2388. https://doi.org/10.1001/jama.2008.711
- Williams, R. B. (2016). Loneliness and social isolation and increased risk of coronary heart disease and stroke: Clinical implications. Heart, 102(24), 2016. https://doi.org/10.1136/heartjnl-2016-310073