Are ceramic implants a viable alternative to titanium implants? A systematic literature review
Marina Andreiotelli
Department of Prosthodontics, School of Dentistry, Albert-Ludwigs University, Freiburg, Germany
Search for more papers by this authorHans J. Wenz
Department of Prosthodontics, Propaedeutics and Dental Materials, School of Dentistry, Christian-Albrechts University, Kiel, Germany
Search for more papers by this authorRalf-Joachim Kohal
Department of Prosthodontics, School of Dentistry, Albert-Ludwigs University, Freiburg, Germany
Search for more papers by this authorMarina Andreiotelli
Department of Prosthodontics, School of Dentistry, Albert-Ludwigs University, Freiburg, Germany
Search for more papers by this authorHans J. Wenz
Department of Prosthodontics, Propaedeutics and Dental Materials, School of Dentistry, Christian-Albrechts University, Kiel, Germany
Search for more papers by this authorRalf-Joachim Kohal
Department of Prosthodontics, School of Dentistry, Albert-Ludwigs University, Freiburg, Germany
Search for more papers by this authorRalf-Joachim Kohal
Hugstetter Straße 55
79106 Freiburg
Germany
Tel.: +49(761) 270 4977
Fax: +49(761) 270 4824
e-mail: [email protected]
Conflicts of interest:
The authors declare no conflicts of interest.
Abstract
Aim: The aim of this systematic review was to screen the literature in order to locate animal and clinical data on bone–implant contact (BIC) and clinical survival/success that would help to answer the question ‘Are ceramic implants a viable alternative to titanium implants?’
Material and methods: A literature search was performed in the following databases: (1) the Cochrane Oral Health Group's Trials Register, (2) the Cochrane Central Register of Controlled Trials (CENTRAL), (3) MEDLINE (Ovid), and (4) PubMed. To evaluate biocompatibility, animal investigations were scrutinized regarding the amount of BIC and to assess implant longevity clinical data were evaluated.
Results: The PubMed search yielded 349 titles and the Cochrane/MEDLINE search yielded 881 titles. Based upon abstract screening and discarding duplicates from both searches, 100 full-text articles were obtained and subjected to additional evaluation. A further publication was included based on the manual search. The selection process resulted in the final sample of 25 studies. No (randomized) controlled clinical trials regarding the outcome of zirconia and alumina ceramic implants could be found.
The systematic review identified histological animal studies showing similar BIC between alumina, zirconia and titanium. Clinical investigations using different alumina oral implants up to 10 years showed survival/success rates in the range of 23 to 98% for different indications. The included zirconia implant studies presented a survival rate from 84% after 21 months to 98% after 1 year.
Conclusions: No difference was found in the rate of osseointegration between the different implant materials in animal experiments. Only cohort investigations were located with questionable scientific value. Alumina implants did not perform satisfactorily and therefore, based on this review, are not a viable alternative to titanium implants. Currently, the scientific clinical data for ceramic implants in general and for zirconia implants in particular are not sufficient to recommend ceramic implants for routine clinical use. Zirconia, however, may have the potential to be a successful implant material, although this is as yet unsupported by clinical investigations.
References
- Adell, R., Hansson, B.O., Brånemark, P.I. & Breine, U. (1970) Intra-osseous anchorage of dental prostheses. II. Review of clinical approaches. Scandinavian Journal of Plastic and Reconstructive Surgery 4: 19–34.
- Adell, R., Lekholm, U., Rockler, B. & Brånemark, P.I. (1981) A 15-year study of osseointegrated implants in the treatment of the edentulous jaw. International Journal of Oral Surgery 10: 387–416.
- Akagawa, Y., Hashimoto, M., Kondo, N., Satomi, K., Takata, T. & Tsuru, H. (1986) Initial bone–implant interfaces of submergible and supramergible endosseous single-crystal sapphire implants. Journal of Prosthetic Dentistry 55: 96–100.
- Akagawa, Y., Hosokawa, R., Sato, Y. & Kamayama, K. (1998) Comparison between freestanding and tooth-connected partially stabilized zirconia implants after two years' function in monkeys: a clinical and histologic study. Journal of Prosthetic Dentistry 80: 551–558.
- Akagawa, Y., Ichikawa, Y., Nikai, H. & Tsuru, H. (1993a) Interface histology of unloaded and early loaded partially stabilized zirconia endosseous implant in initial bone healing. Journal of Prosthetic Dentistry 69: 599–604.
- Akagawa, Y., Matsumoto, T., Hashimoto, M. & Tsuru, H. (1992) Clinical evaluation of the gingiva around single-crystal sapphire endosseous implant after experimental ligature-induced plaque accumulation in monkeys. Journal of Prosthetic Dentistry 68: 111–115.
- Akagawa, Y., Matsumoto, T., Kawamura, M. & Tsuru, H. (1993b) Changes of subgingival microflora around single-crystal sapphire endosseous implants after experimental ligature-induced plaque accumulation in monkeys. Journal of Prosthetic Dentistry 69: 594–598.
- Albrektsson, T. (1983) Direct bone anchorage of dental implants. Journal of Prosthetic Dentistry 50: 255–261.
- Albrektsson, T., Gottlow, J., Meirelles, L., Östman, P.O., Rocci, A. & Sennerby, L. (2007) Survival of NobelDirect implants: an analysis of 550 consecutively placed implants at 18 different clinical centers. Clinical Implants Dentistry & Related Research 9: 65–70.
- Aldini, N.N., Fini, M., Giavaresi, G., Martini, L., Dubini, B., Ponzi Bossi, M.G., Rustichelli, F., Krajewski, A., Ravaglioli, A., Mazzocchi, M. & Giardino, R. (2004) Osteointegration of bioactive glass-coated and uncoated zirconia in osteopenic bone: an in vivo experimental study. Journal of Biomedical Materials Research A 68: 264–272.
- Andreiotelli, M. & Kohal, R.J. (2009) Fracture strength of zirconia implants after artificial aging. Clinical Implants Dentistry & Related Research 11: 158–166.
- Berge, T.I. & Gronningsaeter, A.G. (2000) Survival of single crystal sapphire implants supporting mandibular overdentures. Clinical Oral Implants Research 11: 154–162.
- Bianco, P.D., Ducheyne, P. & Cuckler, J.M. (1996) Local accumulation of titanium released from a titanium implant in the absence of wear. Journal of Biomedical Materials Research 31: 227–234.
- Brånemark, P.I., Adell, R., Albrektsson, T., Lekholm, U., Lindström, J. & Rockler, B. (1984) An experimental and clinical study of osseointegrated implants penetrating the nasal cavity and maxillary sinus. The International Journal of Oral and Maxillofacial Surgery 42: 497–505.
- Brånemark, P.I., Adell, R., Breine, U., Hansson, B.O., Lindström, J. & Ohlsson, A. (1969) Intra-osseous anchorage of dental prostheses. I. Experimental studies. Scandinavian Journal of Plastic and Reconstructive Surgery 3: 81–100.
- Brånemark, P.I., Hansson, B.O., Adell, R., Breine, U., Lindström, J., Hallén, O. & Ohman, A. (1977) Osseointegrated implants in the treatment of the edentulous jaw. Experience from a 10-year period. Scandinavian Journal of Plastic and Reconstructive Surgery 16 (Suppl.): 1–132.
- Brinkmann, E. (1978) Das Keramik-Anker-Implantat nach Mutschelknauss. Zahnärztliche Praxis 29: 148–150.
- Brinkmann, E.L.W. (1987) Das keramische Ankerimplantat als endständiger Brückenpfeiler (Klasse II nach Brinkmann) – Erfahrungsbericht nach zehn Jahren klinischer Anwendung. Quintessenz 38: 811–818.
- Brose, M.O., Reiger, M., Avers, R.J. & Hassler, C.R. (1988) Eight years analysis of alumina dental root implants in human subjects. Journal of Oral Implantology 14: 9–22.
- Carlsson, G.E. (2005) Changes in the prosthodontic literature 1966 to 2042. Journal of the Canadian Dental Association 71: 328–328e.
- Chang, Y.S., Oka, M., Nakamura, T. & Gu, H.O. (1996) Bone remodeling around implanted ceramics. Journal of Biomedical Materials Research 30: 117–124.
10.1002/(SICI)1097-4636(199601)30:1<117::AID-JBM15>3.0.CO;2-L CASPubMedWeb of Science®Google Scholar
- D'Hoedt, B. (1986) 10 Jahre Tübinger Implantat aus Frialit. Eine Zwischenauswertung der Implantatdatei. Zeitschrift für Zahnärztliche Implantologie 2: 6–10.
- D'Hoedt, B. (1991) Dentale Implantate aus polykristalliner Aluminiumoxidkeramik – Einheilung und Langzeitergebnisse. Habilitationschrift, Universität Tübingen.
- D'Hoedt, B., Lukas, D. & Schulte, W. (1986) Das Tübinger Implantat als Sofort- und Spätimplantat, ein statistischer Vergleich. Deutsche Zahnärztliche Zeitschrift 41: 1068–1072.
- D'Hoedt, B. & Schulte, W. (1989) A comparative study of results with various endosseous implant systems. The International Journal of Oral & Maxillofacial Implants 4: 95–105.
- De Wijs, F.L., Van Dongen, R.C., De Lange, G.L. & De Putter, C. (1994) Front tooth replacement with Tübingen (Frialit) implants. Journal of Oral Rehabilitation 21: 11–26.
- Depprich, R., Zipprich, H., Ommerborn, M., Naujoks, C., Wiesmann, H.P., Kiattavorncharoen, S., Lauer, H.C., Meyer, U., Kübler, N.R. & Handschel, J. (2008) Osseointegration of zirconia implants compared with titanium: an in vivo study. Head and Face Medicine 4: 30.
- Dubruillé, J.H., Viguier, E., Le Naour, G., Dubruillé, M.T., Auriol, M. & Le Charpentier, Y. (1999) Evaluation of combinations of titanium, zirconia, and alumina implants with 2 bone fillers in the dog. The International Journal of Oral & Maxillofacial Implants 14: 271–277.
- Ehrl, P.A. (1983) Klinische Studie über Pfeilstift-Implantate nach Mutschelknauss. ZWR Das deutsche Zahnärzteblatt 92: 59–60; 63–64.
- Ehrl, P.A. (1986) Les implants en céramo-alumine aujourd'hui. Le Chirurgien-Dentiste de France 56: 29–36.
- Ehrl, P.A. & Frenkel, G. (1981) Klinische Ergebnisse mit einem enossalen Extensionsimplantat aus Al203-Keramik nach drei Jahren. Quintessenz 32: 2007–2015.
- Esposito, M., Coulthard, P., Worthington, H.V. & Jokstad, A. (2001) Quality assessment of randomized controlled trials of oral implants. The International Journal of Oral & Maxillofacial Implants 16: 783–792.
- Esposito, M., Grusovin, M.G., Coulthard, P., Thomsen, P. & Worthington, H.V. (2005) A 5-year follow-up comparative analysis of the efficacy of various osseointegrated dental implant systems: a systematic review of randomized controlled clinical trials. The International Journal of Oral & Maxillofacial Implants 20: 557–568.
- Fartash, B. & Arvidson, K. (1997) Long-term evaluation of single crystal sapphire implants as abutments in fixed prosthodontics. Clinical Oral Implants Research 8: 58–67.
- Fartash, B., Tangerud, T., Silness, J. & Arvidson, K. (1996) Rehabilitation of mandibular edentulism by single crystal sapphire implants and overdentures: 3–12 year results in 86 patients. A dual center international study. Clinical Oral Implants Research 7: 220–229.
- Hashimoto, M., Akagawa, Y., Nikai, H. & Tsuru, H. (1988) Single-crystal sapphire endosseous dental implant loaded with functional stress – clinical and histological evaluation of peri-implant tissues. Journal of Oral Rehabilitation 15: 65–76.
- Hashimoto, M., Akagawa, Y., Nikai, H. & Tsuru, H. (1989) Ultrastructure of the peri-implant junctional epithelium on single-crystal sapphire endosseous dental implant loaded with functional stress. Journal of Oral Rehabilitation 16: 261–270.
- Hayashi, K., Matsuguchi, N., Uenoyama, K. & Sugioka, Y. (1992) Re-evaluation of the biocompatibility of bioinert ceramics in vivo. Biomaterials 13: 195–200.
- Heydecke, G., Locker, D., Awad, M.A., Lund, J.P. & Feine, J.S. (2003) Oral and general health-related quality of life with conventional and implant dentures. Community Dentistry and Oral Epidemiology 31: 161–168.
- Heydecke, G., Thomason, J.M., Lund, J.P. & Feine, J.S. (2005) The impact of conventional and implant supported prostheses on social and sexual activities in edentulous adults Results from a randomized trial 2 months after treatment. Journal of Dentistry 33: 649–657.
- Hoffmann, O., Angelov, N., Gallez, F., Jung, R.E. & Weber, F.E. (2008) The zirconia implant–bone interface: a preliminary histologic evaluation in rabbits. The International Journal of Oral & Maxillofacial Implants 23: 691–695.
- Jung, R.E., Pjetursson, B.E., Glauser, R., Zembic, A., Zwahlen, M. & Land, N.P. (2008) A systematic review of the 5-year survival and complication rates of implant-supported single crowns. Clinical Oral Implants Research 19: 119–130.
- Kohal, R.J., Klaus, G. & Strub, J.R. (2006) Zirconia-implant-supported all-ceramic crowns withstand long-term load: a pilot investigation. Clinical Oral Implants Research 17: 565–571.
- Kohal, R.J., Weng, D., Bächle, M. & Strub, J.R. (2004) Loaded custom-made zirconia and titanium implants show similar osseointegration: an animal experiment. Journal of Periodontology 75: 1260–1266.
- Koth, D.L., McKinney, R.V., Steflik, D.E. & Davis, Q.B. (1988) Clinical and statistical analyses of human clinical trials with the single crystal aluminum oxide endosteal dental implant: five-year results. Journal of Prosthetic Dentistry 60: 226–234.
- Krempien, B., Schulte, W., Kleineikenscheidt, H., Lindner, K., Schareyka, R. & Heimke, G. (1978) Lichtoptische und rasterelektronenmikroskopische Untersuchungen an der Grenzfläche von Implantaten aus Aluminiumoxid-Keramik im Unterkieferknochen von Hunden. Deutsche Zahnärztliche Zeitschrift 33: 332–340.
- Kuboki, T., Okamoto, S., Suzuki, H., Kanyama, M., Arakawa, H., Sonoyama, W. & Yamashita, A. (1999) Quality of life assessment of bone-anchored fixed partial denture patients with unilateral mandibular distal-extension edentulism. Journal of Prosthetic Dentistry 82: 182–187.
- Lalor, P.A., Revell, P.A., Gray, A.B., Wright, S., Railton, G.T. & Freeman, M.A. (1991) Sensitivity to titanium. A cause of implant failure? Journal of Bone and Joint Surgery – British Volume 73: 25–28.
- Lambrich, M. & Iglhaut, G. (2008) Vergleich der Überlebensrate von Zirkondioxid- und Titanimplantaten. Zeitschrift für Zahnärztliche Implantologie 24: 182–191.
- Lang, N.P., Pjetursson, B.E., Tan, K., Brägger, U., Egger, M. & Zwahlen, M. (2004) A systematic review of the survival and complication rates of fixed partial dentures (FPDs) after an observation period of at least 5 years. II. Combined tooth–implant-supported FPDs. Clinical Oral Implants Research 15: 643–653.
- McKinney, R.V. Jr, Koth, D.L. & Steflik, D.E. (1983) The single crystal sapphire endosseous dental implant. II. Two-year results of clinical animal trials. Journal of Oral Implantology 10: 619–638.
- McKinney, R.V. Jr, Steflik, D.E. & Koth, D.L. (1984a) The biologic response to the single-crystal sapphire endosteal dental implant: scanning electron microscopic observations. Journal of Prosthetic Dentistry 51: 372–379.
- McKinney, R.V. Jr, Steflik, D.E. & Koth, D.L. (1984b) Ultrastructural surface topography of the single crystal sapphire endosseous dental implant. Journal of Oral Implantology 11: 327–340.
- McKinney, R.V.J. & Koth, D.L. (1982) The single-crystal sapphire endosteal dental implant: material characteristics and 18-month experimental animal trials. Journal of Prosthetic Dentistry 47: 69–84.
- Mellinghoff, J. (2006) Erste klinische Ergebnisse zu dentalen Schraubenimplantaten aus Zirkonoxid. Zeitschrift für Zahnärztliche Implantologie 22: 288–293.
- Müller, W., Piesold, J. & Glien, W. (1988) Eigenschaften und klinische Anwendung von Kieferimplantaten aus Aluminiumoxidkeramik Bionit. Stomatologie der DDR 38: 673–678.
- Münch, M. (1984) Das Sofort- und Spatimplantat nach Münch aus Al2O3-Keramik. ZWR Das deutsche Zahnärzteblatt 93: 904–907.
- Needleman, I.G. (2002) A guide to systematic reviews. Journal of Clinical Periodontology 29 (Suppl. 3): 6–9; discussion 37–38.
- Oliva, J., Oliva, X. & Oliva, J.D. (2007) One-year follow-up of first consecutive 100 zirconia dental implants in humans: a comparison of 2 different rough surfaces. The International Journal of Oral & Maxillofacial Implants 22: 430–435.
- Piesold, J.U. (1990) Mechanische und rasterelektronenmikroskopische Untersuchungen zum Langzeitverhalten von Bionit-Kieferimplantaten. Zeitschrift für Zahnärztliche Implantologie 6: 195–200.
- Piesold, J.U. & Müller, W. (1991) Zahnersatz durch Bionit-Implantate. Deutsche Stomatologie 41: 128–132.
- Piesold, J.U., Zschau, H.E., Szafinski, H. & Szafinski, F. (1990) Elementanalytische Untersuchungen zum Korrosionsverhalten von Aluminiumoxidkeramik (Bionit) nach Einwirkung von anorganischen Lösungsmitteln und Säure. Zeitschrift für Zahnärztliche Implantologie 6: 283–288.
- Piesold, J.U., Zschau, H.E., Szafinski, H. & Szafinski, F. (1991) Langzeitverhalten von Bionit-Kieferimplantaten im Tierexperiment. Zeitschrift für Zahnärztliche Implantologie 7: 157–161.
- Pigot, J.L., Dubruillé, J.H., Dubruillé, M.T., Mercier, J.P. & Cohen, P. (1997) Les implants en céramique au secours de la prothèse totale inférieure. Revue de Stomatologie et de Chirurgie maxillofaciale 98: 10–13.
- Pjetursson, B.E., Tan, K., Lang, N.P., Brägger, U., Egger, M. & Zwahlen, M. (2004) A systematic review of the survival and complication rates of fixed partial dentures (FPDs) after an observation period of at least 5 years I. Implant-supported FPDs. Clinical Oral Implants Research 15: 625–642.
- Sandhaus, S. (1968) Tecnica e strumentario dell'impianto C.B.S. (Crystalline Bone Screw). Informatore Odonto-Stomatologico 4: 19–24.
- Sandhaus, S. (1971) Wissenschaftlicher Beitrag zum Gebiet der Oralrehabilitation mit Hilfe des Implantationsverfahrens CBS. Zahnärztliche Welt 80: 597–604.
- Sandhaus, S. (1987) L'implant endo-osseux Cerasand. Actualité Odontostomatologie 41: 607–626.
- Scarano, A., Di Carlo, F., Quaranta, M. & Piattelli, A. (2003) Bone response to zirconia ceramic implants: an experimental study in rabbits. Journal of Oral Implantology 29: 8–12.
- Schroeder, A., Pohler, O. & Sutter, F. (1976) Gewebsreaktion auf ein Titan-Hohlzylinderimplantat mit Titan-Spritzschichtoberfläche. Schweizerische Monatsschrift der Zahnmedizin 86: 713–727.
- Schroeder, A., Stich, H., Straumann, F. & Sutter, F. (1978) Über die Anlagerung von Osteozement an einen belasteten Implantatkörper. Schweizerische Monatsschrift der Zahnmedizin 88: 1051–1058.
- Schroeder, A., Van Der Zypen, E., Stich, H. & Sutter, F. (1981) The reactions of bone, connective tissue, and epithelium to endosteal implants with titanium-sprayed surfaces. Journal of Maxillofacial Surgery 9: 15–25.
- Schulte, W. (1981a) Das enossale Tübinger Implantat aus Al2O3 (Frialit). Der Entwicklungsstand nach 6 Jahren. Zahnärztliche Mitteilungen 71: 1114–1122.
- Schulte, W. (1981b) Das Tübinger Implantat aus Frialit – Fünfjährige Erfahrungen. Deutsche Zahnärztliche Zeitschrift 36: 544–550.
- Schulte, W. (1984) The intra-osseous Al2O3 (Frialit) Tübingen Implant. Developmental status after eight years (I–III). Quintessence International 15: 1–39.
- Schulte, W. (1985) Das Tübinger Implantat. Schweizerische Monatsschrift der Zahnmedizin 95: 872–875.
- Schulte, W. & D'Hoedt, B. (1988) 13 Jahre Tübinger Implantat aus Frialit – Weitere Ergebnisse. Zeitschrift für Zahnärztliche Implantologie 3: 167–172.
- Schulte, W., D'Hoedt, B., Axman, D. & Gomez-Roman, G. (1992) 15 Jahre Tübinger Implantat und seine Weiterentwicklung zum Frialit-2 System. Zeitschrift für Zahnärztliche Implantologie 8: 77–96.
- Schulte, W. & Heimke, A. (1976) Das Tübinger Sofort-Implantat. Quintessenz 27: 17–23.
- Schulte, W., Kleineikenscheidt, H., Lindner, K. & Schareyka, R. (1978a) Das Tübinger Sofortimplantat in der klinischen Prüfung. Deutsche Zahnärztliche Zeitschrift 33: 348–359.
- Schulte, W., Kleineikenscheidt, H., Lindner, K., Schareyka, R., Heimke, G., Gerlach, C. & Hardegg, W. (1978b) Tierexperimente zur Frage der Einheilung des Tübinger Sofortimplantates. Deutsche Zahnärztliche Zeitschrift 33: 326–331.
- Schulz, P., Heimke, G., Krempien, B., Kristen, K., Mühleisen, W. & Singer, R. (1981) Einzelzahnimplantate aus Aluminiumoxidkeramik im Beagle-Seitenzahnbereich und für Frontzahnlücken des jugendlichen Patienten. Deutsche Zahnärztliche Zeitschrift 36: 599–606.
- Sclaroff, A., El-Mofty, S. & Guyer, S.E. (1990) Clinical evaluation of a single crystal sapphire tooth implant in human beings. Oral Surgery, Oral Medicine and Oral Pathology 70: 141–146.
- Sennerby, L., Dasmah, A., Larsson, B. & Iverhed, M. (2005) Bone tissue responses to surface-modified zirconia implants: a histomorphometric and removal torque study in the rabbit. Clinical Implants Dentistry & Related Research 7 (Suppl. 1): S13–S20.
- Sicilia, A., Cuesta, S., Coma, G., Arregui, I., Guisasola, C., Ruiz, E. & Maestro, A. (2008) Titanium allergy in dental implant patients: a clinical study on 1500 consecutive patients. Clinical Oral Implants Research 19: 823–835.
- Silva, N.R., Coelho, P.G., Fernandes, C.A., Navarro, J.M., Dias, R.A. & Thompson, V.P. (2009) Reliability of one-piece ceramic implant. Journal of Biomedical Materials Research Part B: Applied Biomaterials 88: 419–426.
- Stanic, V., Aldini, N.N., Fini, M., Giavaresi, G., Giardino, R., Krajewski, A., Ravaglioli, A., Mazzocchi, M., Dubini, B., Bossi, M.G. & Rustichelli, F. (2002) Osteointegration of bioactive glass-coated zirconia in healthy bone: an in vivo evaluation. Biomaterials 23: 3833–3841.
- Steflik, D.E., Koth, D.L. & McKinney, R.V. Jr (1984) A clinical and statistical analysis of human clinical trails with the single crystal sapphire endosteal dental implant: two year results. Journal of Oral Implantology 11: 500–515.
- Steflik, D.E., Koth, D.L. & McKinney, R.V. Jr (1987) Human clinical trials with the single crystal sapphire endosteal dental implant: three year results, statistical analysis, and validation of an evaluation protocol. Journal of Oral Implantology 13: 39–53.
- Steflik, D.E., Koth, D.L., Robinson, F.G., McKinney, R.V., Davis, B.C., Morris, C.F. & Davis, Q.B. (1995) Prospective investigation of the single-crystal sapphire endosteal dental implant in humans: ten-year results. Journal of Oral Implantology 21: 8–18.
- Strassl, H. (1988) Dreijährige klinische Erfahrung mit dem Implantat aus Aluminiumoxyd nach Münch. Zahnärztliche Praxis 39: 84–88.
- Strub, J.R., Rohner, D. & Schärer, P. (1987) Die Versorgung des Lückengebißes mit implantatgetragenen Brücken. Eine Longitudinalstudie über 7,5 Jahre. Zeitschrift für Zahnärztliche Implantologie 3: 242–254.
- Sutherland, S.E. (2000) The building blocks of evidence-based dentistry. Journal of the Canadian Dental Association 66: 241–244.
- Tschernitschek, H., Borchers, L. & Geurtsen, W. (2005) Nonalloyed titanium as a bioinert metal – a review. Quintessence International 36: 523–530.
- US Department of Health and Human Services. (1993) Agency for Health Care Policy and Research. AHCPR Publication No.92-0023: Acute Pain Management: Operative or Medical Procedures and Trauma. Clinical Practice Guideline No. 1. Appendix B, http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=hstat6.table.9286 (last accessed 19 June 2009).
- Weingart, D., Steinemann, S., Schilli, W., Strub, J.R., Hellerich, U., Assenmacher, J. & Simpson, J. (1994) Titanium deposition in regional lymph nodes after insertion of titanium screw implants in maxillofacial region. The International Journal of Oral and Maxillofacial Surgery 23: 450–452.
- Wenz, H.J., Bartsch, J., Wolfart, S. & Kern, M. (2008) Osseointegration and clinical success of zirconia dental implants: a systematic review. International Journal of Prosthodontics 21: 27–36.
- Wörle, M. (1981) Klinische Erfahrungen mit enossalen Aluminiumoxidkeramik-Implantaten. Deutsche Zahnärztliche Zeitschrift 36: 591–595.
List of excluded full-text articles and the reason for exclusion
- Akagawa, Y., Hashimoto, M., Kondo, N., Satomi, K., Takata, T. & Tsuru, H. (1986) Initial bone–implant interfaces of submergible and supramergible endosseous single-crystal sapphire implants. The Journal of Prosthetic Dentistry 55: 96–100. Exclusion criteria: no bone-to-implant contact reported.
- Atkinson, P.J., Roberts, E.W. & Khudayer, Z.M. (1984) Porous ceramic materials as immediate root implants. Journal of Dentistry 12: 189–202. Exclusion criteria: no bone-to-implant contact reported.
- Blaschke, C. & Volz, U. (2006) Soft and hard tissue response to zirconium dioxide dental implants – a clinical study in man. Neuroendocrinology Letters 27 (Suppl. 1): 69–72. Exclusion criteria: no survival/success rate reported.
- Brinkmann, E. (1978) Das Keramik-Anker-Implantat nach Mutschelknauss. Zahnärztliche Praxis 29: 148–150. Exclusion criteria: presentation of an implant system.
- Brinkmann, E. (1980) Enossale Implantate aus Aluminiumoxidkeramik. Zahnärztliche Praxis 31: 328–330. Exclusion criteria: editorial paper.
- Brinkmann, E. (1983) Indikation und Anwendung keramischer Implantate aus Aluminiumoxid (Biolox). Swiss Dent 4: 23–24; 28, 29–30 passim. Exclusion criteria: review.
- Brinkmann, E. & Dörre, E. (1981) Das Biolox-Schrauben-Implantat. Zahnärztliche Praxis 32: 528–534. Exclusion criteria: presentation of an implant system.
- Brinkmann, E.L. (1987) Das keramische Ankerimplantat als endständiger Brückenpfeiler (Klasse II nach Brinkmann)–Erfahrungsbericht nach zehn Jahren klinischer Anwendung (II). Quintessenz 38: 993–1003. Exclusion criteria: presentation of an implant system.
- Brose, M.O., Rieger, M.R., Downes, R.J. & Hassler, C.R. (1987a) Eight-year study of alumina tooth implants in baboons. The Journal of Oral Implantology 13: 409–425. Exclusion criteria: no bone-to-implant contact reported.
- Brose, M.O., Rieger, M.R. & Driskell, T.D. (1987b) Multicrystalline aluminum oxide tooth implants in rhesus monkeys. The Journal of Oral Implantology 13: 204–214. Exclusion criteria: no bone-to-implant contact reported.
- Buquet, J. (1987) L'implant saphir. Monocristal d'alumine. Actualités odonto-stomatologiques 41: 673–691. Exclusion criteria: review.
- Cabrini, R.L., Guglielmotti, M.B. & Almagro, J.C. (1993) Histomorphometry of initial bone healing around zirconium implants in rats. Implant Dentistry 2: 264–267. Exclusion criteria: no ceramic implants investigated.
- Chess, J.T. (1979) Current status of the Synthodont aluminum oxide ceramic implant. Journal of Oral Implantology 8: 654–658. Exclusion criteria: presentation of an implant system, no clinical investigation, no patient or implant numbers, no survival/success rate reported.
- Chess, J.T. & Babbush, C.A. (1980) Restoration of lost dentition using aluminum oxide endosteal implants. Dental Clinics of North America 24: 521–533. Exclusion criteria: presentation of an implant system.
- Christel, P., Meunier, A., Heller, M., Torre, J.P. & Peille, C.N. (1989) Mechanical properties and short-term in-vivo evaluation of yttrium-oxide-partially-stabilized zirconia. Journal of Biomedical Materials Research 23: 45–61. Exclusion criteria: no bone-to-implant contact reported.
- Cook, S.D., Anderson, R.C. & Lavernia, C.J. (1983a) Histologic and microradiographic evaluation of textured and nontextured aluminum oxide dental implants. Biomaterials, Medical Devices, and Artificial Organs 11: 259–269. Exclusion criteria: no bone-to-implant contact reported.
- Cook, S.D., Weinstein, A.M., Klawitter, J.J. & Kent, J.N. (1983b) Quantitative histologic evaluation of LTI carbon, carbon-coated aluminum oxide and uncoated aluminum oxide dental implants. Journal of Biomedical Materials Research 17: 519–538. Exclusion criteria: no bone-to-implant contact reported.
- Cremer, T. (1987) L'implant dentaire en Al2O3 Frialite. Actualités odonto-stomatologiques 41: 641–648. Exclusion criteria: presentation of an implant system.
- D'Hoedt, B. & Schulte, W. (1987) Möglichkeiten und Langzeitergebnisse bei der Anwendung Tübinger Implantate (Frialit). ZWR Das Deutsche Zahnärzteblatt 96: 118–121. Exclusion criteria: case series, no protocol for a clinical study.
- D'Hoedt, B. & Schulte, W. (1989) A comparative study of results with various endosseous implant systems. The International Journal of Oral & Maxillofacial Implants 4: 95–105. Exclusion criteria: no survival/success rate reported.
- De Wijs, F.L., De Putter, C. & Cune, M.S. (1996) Front tooth replacement with Tübingen (Frialit) implants: a radiographical evaluation. Journal of Oral Rehabilitation 23: 97–100. Exclusion criteria: only radiographical evaluation of the implants.
- Donath, K. (1986) Ist die Osteointegration der Dentalimplantate abhängig vom Implantatmaterial? ZWR Das Deutsche Zahnärzteblatt 95: 1146–1148. Exclusion criteria: only human biopsies, no clinical study.
- Dörre, E. (1980) Aluminiumoxid-Keramik – ein Werkstoff für enossale Implantate. Zahnärztliche Praxis 31: 343–346. Exclusion criteria: no animal, no clinical study.
- Ehrl, P.A. (1981) Klinische Studie zur Beurteilung von enossalen Al2O3-Keramik-Implantaten mit parodontologischen Kriterien. Deutsche Zahnärztliche Zeitschrift 36: 500–504. Exclusion criteria: no survival/success rate reported.
- Ehrl, P.A. (1983a) Klinische Studie über Pfeilstift-Implantate nach Mutschelknauss. ZWR Das Deutsche Zahnärzteblatt 92: 59–60; 63–54. Exclusion criteria: no observation period and patient number reported.
- Ehrl, P.A. (1983b) Vergleichende Untersuchung von Einzelzahn- und Blattimplantaten aus Al2O3-Keramik. Österreichische Zeitschrift für Stomatologie 80: 97–102. Exclusion criteria: no survival/success rate reported.
- Ehrl, P.A. (1986) Les implants en céramo-alumine aujourd'hui. Le Chirurgien-dentiste de France 56: 29–36. Exclusion criteria: review, presentation of an implant system.
- Ehrl, P.A., Reuther, J. & Frenkel, G. (1981) Al2O3-ceramic as material for dental implants: experimental and clinical study for the development of screw- and extension-implants. International Journal of Oral Surgery 10: 93–98. Exclusion criteria: case series, no protocol for a clinical study.
- Fartash, B., Eliasson, S. & Arvidson, K. (1995) Mandibular single crystal sapphire implants: changes in crestal bone levels over three years. Clinical Oral Implants Research 6: 181–188. Exclusion criteria: only radiographical evaluation of the implants.
- Fritzemeier, C.U., Lentrodt, J., Holtje, W. & Osborn, J.F. (1981) Bisherige Erfahrungen mit dem Tübinger Sofortimplantat aus Aluminium-Oxydkeramik. Deutsche Zahnärztliche Zeitschrift 36: 579–584. Exclusion criteria: case series, no protocol for a clinical study.
- Gahlert, M., Gudehus, T., Eichhorn, S., Steinhauser, E., Kniha, H. & Erhardt, W. (2007) Biomechanical and histomorphometric comparison between zirconia implants with varying surface textures and a titanium implant in the maxilla of miniature pigs. Clinical Oral Implants Research 18: 662–668. Exclusion criteria: no bone-to-implant contact reported.
- Guglielmotti, M.B., Guerrero, C. & Cabrini, R.L. (1997) Chronodynamic evaluation of the stages of osseointegration in zirconium laminar implants. Acta Odontológica Latinoamericana 10: 11–23. Exclusion criteria: no ceramic implants investigated.
- Guglielmotti, M.B., Renou, S. & Cabrini, R.L. (1999) A histomorphometric study of tissue interface by laminar implant test in rats. The International Journal of Oral & Maxillofacial Implants 14: 565–570. Exclusion criteria: no ceramic implants investigated.
- Hashimoto, M., Akagawa, Y., Nikai, H. & Tsuru, H. (1988) Single-crystal sapphire endosseous dental implant loaded with functional stress – clinical and histological evaluation of peri-implant tissues. Journal of Oral Rehabilitation 15: 65–76. Exclusion criteria: no bone-to-implant contact reported.
- Hobkirk, J.A. (1981) Patterns of cortical bone growth around alumina implants. Journal of Oral Rehabilitation 8: 143–154. Exclusion criteria: no bone-to-implant contact reported.
- Kent, J.N., Cook, S.D., Weinstein, A.M. & Klawitter, J.J. (1982) A clinical comparison of LTI carbon, alumina, and carbon-coated alumina blade-type implants in baboons. Journal of Biomedical Materials Research 16: 887–899. Exclusion criteria: no bone-to-implant contact reported.
- Klawitter, J.J., Weinstein, A.M., Cooke, F.W., Peterson, L.J., Pennel, B.M. & McKinney, R.V. Jr (1977) An evaluation of porous alumina ceramic dental implants. Journal of Dental Research 56: 768–776. Exclusion criteria: no bone-to-implant contact reported.
- Klawitter, J.J., Weinstein, A.M., Cooke, F.W., Peterson, L.J., Pennel, B.M. & McKinney, R.V. Jr (1980) An evaluation of porous alumina ceramic dental implants. The Journal of Oral Implantology 9: 64–82. Exclusion criteria: no bone-to-implant contact reported.
- Krempien, B., Schulte, W., Kleineikenscheidt, H., Lindner, K., Schareyka, R. & Heimke, G. (1978) Lichtoptische und rasterelektronenmikroskopische Untersuchungen an der Grenzfläche von Implantaten aus Aluminiumoxid-Keramik im Unterkieferknochen von Hunden. Deutsche Zahnärztliche Zeitschrift 33: 332–340. Exclusion criteria: no bone-to-implant contact reported.
- Marinho, V.C., Celletti, R., Bracchetti, G., Petrone, G., Minkin, C. & Piattelli, A. (2003) Sandblasted and acid-etched dental implants: a histologic study in rats. The International Journal of Oral & Maxillofacial Implants 18: 75–81. Exclusion criteria: report on titanium implants.
- McKinney, R.V. Jr, Koth, D.L. & Steflik, D.E. (1983) The single crystal sapphire endosseous dental implant. II. Two-year results of clinical animal trials. Journal of Oral Implantology 10: 619–638. Exclusion criteria: no bone-to-implant contact reported.
- Missika, P. (1987) Les implants en céramique alumineuse Biolox. Actualités odonto-stomatologiques 41: 657–672. Exclusion criteria: presentation of an implant system.
- Müller, W., Piesold, J. & Glien, W. (1988) Eigenschaften und klinische Anwendung von Kieferimplantaten aus Aluminiumoxidkeramik Bionit. Stomatologie der DDR 38: 673–678. Exclusion criteria: no survival/success rate reported.
- Münch, M. (1987) Das Sofort- und Spatimplantat nach Münch aus Biolox. Ein klinischer Erfahrungsbericht nach sechs Jahren. ZWR Das Deutsche Zahnärzteblatt 96: 456–458; 460, 464–456. Exclusion criteria: no observation period and patient number reported.
- Mutschelknauss, E. & Dörre, E. (1977) Extensionsimplantate aus Aluminiumoxid-Keramik (I). Quintessenz 28: 21–25. Exclusion criteria: presentation of an implant system.
- Nentwig, G.H. (1985) Enossale Implantate aus Aluminiumoxidkeramik (Al2O3). Zahnarzt 29: 87–97. Exclusion criteria: review.
- Neunhoeffer, H. (1981) Prothetische Versorgung von Implantaten aus Aluminiumoxid-Keramik. Quintessenz 32: 2049–2053. Exclusion criteria: case series, no protocol for a clinical study.
- Nordlund, A., Zetterqvist, L. & Oden, A. (1989) A comparative experimental investigation in monkeys between three different implant materials. The International Journal of Oral & Maxillofacial Implants 18: 373–377. Exclusion criteria: no bone-to-implant contact reported.
- Parr, G.R., Gardner, L.K., Steflik, D.E., Sisk, A.L. & Hanes, P.J. (1992) Comparative implant research in dogs: prosthodontic protocol using two-stage ceramic endosseous dental implants. The International Journal of Oral & Maxillofacial Implants 7: 508–512. Exclusion criteria: no bone-to-implant contact reported.
- Pedersen, K.N. (1979) Tissue reaction to submerged ceramic tooth root implants. An experimental study in monkeys. Acta Odontologica Scandinavica 37: 347–352. Exclusion criteria: no bone-to-implant contact reported.
- Pedersen, K.N. & Haanaes, H.R. (1980) Further studies on tissue ingrowth into intrabony porous ceramic implants. International Journal of Oral Surgery 9: 140–143. Exclusion criteria: no bone-to-implant contact reported.
- Reichart, P. (1979) Tierexperimentelle Untersuchungen an Aluminiumoxid-Keramik-Implantaten. Zahnärztliche Praxis 30: 511–514. Exclusion criteria: no bone-to-implant contact reported.
- Schulte, W. (1981) Das Tübinger Implantat aus Frialit – Fünfjährige Erfahrungen. Deutsche Zahnärztliche Zeitschrift 36: 544–550. Exclusion criteria: presentation of an implant system.
- Schulte, W. & Heimke, G. (1980) Implants endo-osseux de céramique a base d'oxyde d'alumine (Frialit-type Tübingen). Le Chirurgien-dentiste de France 50: 41–45. Exclusion criteria: review.
- Schulte, W., Kleineikenscheidt, H., Lindner, K., Schareyka, R., Heimke, G., Gerlach, C. & Hardegg, W. (1978) Tierexperimente zur Frage der Einheilung des Tübinger Sofortimplantates. Deutsche Zahnärztliche Zeitschrift 33: 326–331. Exclusion criteria: no bone-to-implant contact reported.
- Schultze-Mosgau, S., Schliephake, H., Radespiel-Tröger, M. & Neukam, F.W. (2000) Osseointegration of endodontic endosseous cones: zirconium oxide vs titanium. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics 89: 91–98. Exclusion criteria: no bone-to-implant contact reported.
- Schulz, P., Heimke, G., Krempien, B., Kristen, K., Mühleisen, W. & Singer, R. (1981) Einzelzahnimplantate aus Aluminiumoxidkeramik im Beagle-Seitenzahnbereich und für Frontzahnlücken des jugendlichen Patienten. Deutsche Zahnärztliche Zeitschrift 36: 599–606. Exclusion criteria: no bone-to-implant contact reported.
- Sisk, A.L., Steflik, D.E., Parr, G.R. & Hanes, P.J. (1992) A light and electron microscopic comparison of osseointegration of six implant types. The International Journal of Oral and Maxillofacial Surgery 50: 709–716; discussion 716–707. Exclusion criteria: no bone-to-implant contact reported.
- Smith, J.R. (1979) Bone dynamics associated with the controlled loading of bioglass-coated aluminum oxide endosteal implants. American Journal of Orthodontics 76: 618–636. Exclusion criteria: no bone-to-implant contact reported.
- Sollazzo, V., Pezzetti, F., Scarano, A., Piattelli, A., Bignozzi, C.A., Massari, L., Brunelli, G. & Carinci, F. (2008) Zirconium oxide coating improves implant osseointegration in vivo. Dental Materials 24: 357–361. Exclusion criteria: investigation on titanium implants.
- Stallard, R.E. (1981) Tissue reaction to non-metallic dental implants. The New York State Dental Journal 47: 20–23. Exclusion criteria: review.
- Steflik, D.E., Koth, D.L. & McKinney, R.V. Jr (1984) A clinical and statistical analysis of human clinical trails with the single crystal sapphire endosteal dental implant: two year results. Journal of Oral Implantology 11: 500–515. Exclusion criteria: reported patient group same as in Koth et. al. (1988) and Steflik et al.(1995).
- Steflik, D.E., Koth, D.L. & McKinney, R.V. Jr (1987) Human clinical trials with the single crystal sapphire endosteal dental implant: three year results, statistical analysis, and validation of an evaluation protocol. Journal of Oral Implantology 13: 39–53. Exclusion criteria: reported patient group same as in Koth et. al. (1988) and Steflik et al.(1995).
- Steflik, D.E., McKinney, R.V. Jr & Koth, D.L. (1983) A statistical analysis of the clinical response to the single-crystal sapphire endosseous dental implant in dog jaws. Journal of Dental Research 62: 1212–1215. Exclusion criteria: no bone-to-implant contact reported.
- Strassl, H. (1988) Dreijährige klinische Erfahrung mit dem Implantat aus Aluminiumoxyd nach Münch. Zahnärztliche Praxis 39: 84–88. Exclusion criteria: no observation period reported.
- Takahashi, T., Sato, T., Hisanaga, R., Miho, O., Suzuki, Y., Tsunoda, M. & Nakagawa, K. (2008) Long-term observation of porous sapphire dental implants. The Bulletin of Tokyo Dental College 49: 23–27. Exclusion criteria: case series.
- Takuma, M., Harada, S., Kurokawa, F., Takashima, F., Miyauchi, S. & Maruyama, T. (1987) Experimental study on the functional adaptation to aluminum oxide, hydroxyapatite and titanium implants. The Journal of Osaka University Dental School 27: 111–121. Exclusion criteria: no bone-to-implant contact reported.
- Vanhakendover, S. (1987) Endosseous screw-implants in aluminium ceramic (crystalline bone screw and Cerasand). Actualités odonto-stomatologiques 41: 627–640. Exclusion criteria: no patient number reported.
- Wagner, W., Tetsch, P. & Bossler, L. (1981) Bisherige klinische Erfahrungen mit dem Frialit-Implantat Typ Tübingen. Deutsche Zahnärztliche Zeitschrift 36: 585–590. Exclusion criteria: no observation period reported.
- Weinstein, A.M., Cook, S.D., Klawitter, J.J., Weinberg, L.A. & Zide, M. (1981) An evaluation of ion-textured aluminum oxide dental implants. Journal of Biomedical Materials Research 15: 749–756. Exclusion criteria: no bone-to-implantcontact reported.
- Willmann, G., Von Chamier, W. & Dörre, E. (1990) Schraubenimplantate aus Aluminiumoxid. Zahnärztliche Praxis 41: 447–448; 450–442. Exclusion criteria: presentation of an implant system.
- Yamagami, A., Kotera, S., Ehara, Y. & Nishio, Y. (1988) Porous alumina for free-standing implants. Part I: implant design and in vivo animal studies. The Journal of Prosthetic Dentistry 59: 689–695. Exclusion criteria: no bone-to-implant contact reported.
- Yamane, T., Yuasa, Y., Matsuzawa, K. & Yamanouchi, H. (1979) Fundamental and clinical studies on endosseous implant of new sapphire (alpha-A1203) material. Journal of Oral Implantology 8: 232–256. Exclusion criteria: no bone-to-implant contact reported.
- Zetterqvist, L., Anneroth, G. & Nordenram, A. (1991) Tissue integration of Al2O3-ceramic dental implants: an experimental study in monkeys. The International Journal of Oral & Maxillofacial Implants 6: 285–293. Exclusion criteria: no bone-to-implant contact reported.
- Zetterqvist, L., Anneroth, G., Nordenram, A. & Wroblewski, R. (1995) X-ray microanalytical and morphological observations of the interface region between ceramic implant and bone. Clinical Oral Implants Research 6: 104–113. Exclusion criteria: no bone-to-implant contact reported.