Volume 54, Issue 6 p. 670-677

Adolescent subthreshold-depression and anxiety: psychopathology, functional impairment and increased suicide risk

Judit Balázs

Judit Balázs

Vadaskert Child and Adolescent Psychiatric Hospital, Budapest, Hungary

Institute of Psychology, Eötvös Loránd University, Budapest, Hungary

Search for more papers by this author
Mónika Miklósi

Mónika Miklósi

Semmelweis University, School of Ph.D. Studies, Budapest, Hungary

Heim Pál Paediatric Hospital, Budapest, Hungary

Search for more papers by this author
Ágnes Keresztény

Ágnes Keresztény

Vadaskert Child and Adolescent Psychiatric Hospital, Budapest, Hungary

Semmelweis University, School of Ph.D. Studies, Budapest, Hungary

Search for more papers by this author
Christina W. Hoven

Christina W. Hoven

Department of Child and Adolescent Psychiatry, Columbia University-New York State Psychiatric Institute, New York, NY, USA

Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA

Search for more papers by this author
Vladimir Carli

Vladimir Carli

National Centre for Suicide Research and Prevention of Mental Ill-Health (NASP), Karolinska Institute, Stockholm, Sweden

Search for more papers by this author
Camilla Wasserman

Camilla Wasserman

Department of Child and Adolescent Psychiatry, Columbia University-New York State Psychiatric Institute, New York, NY, USA

Medicine and Health Science Department, University of Molise, Campobasso, Italy

Search for more papers by this author
Alan Apter

Alan Apter

Feinberg Child Study Center, Schneider Children’s Medical Center, Tel Aviv University, Tel Aviv, Israel

Search for more papers by this author
Julio Bobes

Julio Bobes

Department of Psychiatry, School of Medicine, University of Oviedo; Centro de InvestigaciónBiomédica en Red de Salud Mental, CIBERSAM, Oviedo, Spain

Search for more papers by this author
Romuald Brunner

Romuald Brunner

Section Disorders of Personality Development, Clinic of Child and Adolescent Psychiatry, University of Heidelberg, Heidelberg, Germany

Search for more papers by this author
Doina Cosman

Doina Cosman

Clinical Psychology Department, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania

Search for more papers by this author
Pádraig Cotter

Pádraig Cotter

National Suicide Research Foundation, Cork, Ireland

Search for more papers by this author
Christian Haring

Christian Haring

Research Division for Mental Health, University for Medical Information Technology (UMIT), Innsbruck, Austria

Search for more papers by this author
Miriam Iosue

Miriam Iosue

Medicine and Health Science Department, University of Molise, Campobasso, Italy

Search for more papers by this author
Michael Kaess

Michael Kaess

Section Disorders of Personality Development, Clinic of Child and Adolescent Psychiatry, University of Heidelberg, Heidelberg, Germany

Orygen Youth Health Research Centre, The University of Melbourne, Melbourne, Vic., Australia

Search for more papers by this author
Jean-Pierre Kahn

Jean-Pierre Kahn

Department of Psychiatry, Centre Hospitalo-Universitaire (CHU) de NANCY, Université H. Poincaré, NANCY-France

Search for more papers by this author
Helen Keeley

Helen Keeley

National Suicide Research Foundation, Cork, Ireland

Search for more papers by this author
Dragan Marusic

Dragan Marusic

Mental Health Department, PINT, University of Primorska, Primorska, Slovenia

Search for more papers by this author
Vita Postuvan

Vita Postuvan

Mental Health Department, PINT, University of Primorska, Primorska, Slovenia

Search for more papers by this author
Franz Resch

Franz Resch

Section Disorders of Personality Development, Clinic of Child and Adolescent Psychiatry, University of Heidelberg, Heidelberg, Germany

Search for more papers by this author
Pilar A Saiz

Pilar A Saiz

Department of Psychiatry, School of Medicine, University of Oviedo; Centro de InvestigaciónBiomédica en Red de Salud Mental, CIBERSAM, Oviedo, Spain

Search for more papers by this author
Merike Sisask

Merike Sisask

Estonian-Swedish Mental Health & Suicidology Institute, Ctr. Behav & Hlth Sci, Tallinn University, Tallinn, Estonia

Search for more papers by this author
Avigal Snir

Avigal Snir

Feinberg Child Study Center, Schneider Children’s Medical Center, Tel Aviv University, Tel Aviv, Israel

Search for more papers by this author
Alexandra Tubiana

Alexandra Tubiana

Department of Psychiatry, Centre Hospitalo-Universitaire (CHU) de NANCY, Université H. Poincaré, NANCY-France

Search for more papers by this author
Airi Varnik

Airi Varnik

Estonian-Swedish Mental Health & Suicidology Institute, Ctr. Behav & Hlth Sci, Tallinn University, Tallinn, Estonia

Search for more papers by this author
Marco Sarchiapone

Marco Sarchiapone

Medicine and Health Science Department, University of Molise, Campobasso, Italy

Search for more papers by this author
Danuta Wasserman

Danuta Wasserman

National Centre for Suicide Research and Prevention of Mental Ill-Health (NASP), Karolinska Institute, Stockholm, Sweden

Search for more papers by this author
First published: 18 January 2013
Citations: 362

Conflicts of interest statement: No conflicts declared.

Abstract

Background: Subthreshold-depression and anxiety have been associated with significant impairments in adults. This study investigates the characteristics of adolescent subthreshold-depression and anxiety with a focus on suicidality, using both categorical and dimensional diagnostic models.

Methods: Data were drawn from the Saving and Empowering Young Lives in Europe (SEYLE) study, comprising 12,395 adolescents from 11 countries. Based on self-report, including Beck Depression Inventory-II (BDI-II), Zung Self-Rating Anxiety Scale (SAS), Strengths and Difficulties Questionnaire (SDQ) and Paykel Suicide Scale (PSS) were administered to students. Based on BDI-II, adolescents were divided into three groups: nondepressed, subthreshold-depressed and depressed; based on the SAS, they were divided into nonanxiety, subthreshold-anxiety and anxiety groups. Analyses of Covariance were conducted on SDQ scores to explore psychopathology of the defined groups. Logistic regression analyses were conducted to explore the relationships between functional impairments, suicidality and subthreshold and full syndromes.

Results: Thirty-two percent of the adolescents were subthreshold-anxious and 5.8% anxious, 29.2% subthreshold-depressed and 10.5% depressed, with high comorbidity. Mean scores of SDQ of subthreshold-depressed/anxious were significantly higher than the mean scores of the nondepressed/nonanxious groups and significantly lower than those of the depressed/anxious groups. Both subthreshold and threshold-anxiety and depression were related to functional impairment and suicidality.

Conclusions: Subthreshold-depression and subthreshold-anxiety are associated with an increased burden of disease and suicide risk. These results highlight the importance of early identification of adolescent subthreshold-depression and anxiety to minimize suicide. Incorporating these subthreshold disorders into a diagnosis could provide a bridge between categorical and dimensional diagnostic models.