Chimeric spike mRNA vaccines protect against Sarbecovirus challenge in mice
A broad defense against SARS-like viruses
Abstract
Results
Design and expression of chimeric spike constructs to cover pandemic and zoonotic SARS-related coronaviruses
Immunogenicity of mRNAs expressing chimeric spike constructs against coronaviruses
Neutralizing antibody responses against live Sarbecoviruses and variants of concern
In vivo protection against heterologous Sarbecovirus challenge
Lung pathology and cytokines in mRNA-LNP–vaccinated mice challenged with epidemic and pandemic coronaviruses
Discussion
Acknowledgments
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27 August 2021
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- David R. Martinez et al.
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