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Special Perspectives

Host Species Barriers to Influenza Virus Infections

Science
21 Apr 2006
Vol 312, Issue 5772
pp. 394-397

Abstract

Most emerging infectious diseases in humans originate from animal reservoirs; to contain and eradicate these diseases we need to understand how and why some pathogens become capable of crossing host species barriers. Influenza virus illustrates the interaction of factors that limit the transmission and subsequent establishment of an infection in a novel host species. Influenza species barriers can be categorized into virus-host interactions occurring within individuals and host-host interactions, either within or between species, that affect transmission between individuals. Viral evolution can help surmount species barriers, principally by affecting virus-host interactions; however, evolving the capability for sustained transmission in a new host species represents a major adaptive challenge because the number of mutations required is often large.

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Published In

Science
Volume 312 | Issue 5772
21 April 2006

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Published in print: 21 April 2006

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Authors

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Thijs Kuiken* [email protected]
Department of Virology, Erasmus Medical Center, 3015 GE Rotterdam, Netherlands.
Edward C. Holmes
Center for Infectious Disease Dynamics, Department of Biology, Pennsylvania State University, University Park, PA 16802, USA.
John McCauley
Institute for Animal Health, Compton Laboratory, Compton, Newbury, Berkshire RG20 7NN, UK.
Guus F. Rimmelzwaan
Department of Virology, Erasmus Medical Center, 3015 GE Rotterdam, Netherlands.
Catherine S. Williams
Center for Infectious Disease Dynamics, Department of Biology, Pennsylvania State University, University Park, PA 16802, USA.
Bryan T. Grenfell
Center for Infectious Disease Dynamics, Department of Biology, Pennsylvania State University, University Park, PA 16802, USA.
Fogarty International Center, National Institutes of Health, Bethesda, MD 20892, USA.

Notes

*
To whom correspondence should be addressed. E-mail: [email protected]

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