PI-RADS Steering Committee: The PI-RADS Multiparametric MRI and MRI-directed Biopsy Pathway

Author Affiliations

Published Online:Jun 11 2019https://doi.org/10.1148/radiol.2019182946

Abstract

The Prostate Imaging Reporting and Data System MRI-directed biopsy pathway enables the delivery of key diagnostic benefits to men suspected of having cancer according to their clinical priorities.

High-quality evidence shows that MRI in biopsy-naive men can reduce the number of men who need prostate biopsy and can reduce the number of diagnoses of clinically insignificant cancers that are unlikely to cause harm. In men with prior negative biopsy results who remain under persistent suspicion, MRI improves the detection and localization of life-threatening prostate cancer with greater clinical utility than the current standard of care, systematic transrectal US-guided biopsy. Systematic analyses show that MRI-directed biopsy increases the effectiveness of the prostate cancer diagnosis pathway. The incorporation of MRI-directed pathways into clinical care guidelines in prostate cancer detection has begun. The widespread adoption of the Prostate Imaging Reporting and Data System (PI-RADS) for multiparametric MRI data acquisition, interpretation, and reporting has promoted these changes in practice. The PI-RADS MRI-directed biopsy pathway enables the delivery of key diagnostic benefits to men suspected of having cancer based on clinical suspicion. Herein, the PI-RADS Steering Committee discusses how the MRI pathway should be incorporated into routine clinical practice and the challenges in delivering the positive health impacts needed by men suspected of having clinically significant prostate cancer.

Online supplemental material is available for this article.

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Article History

Received: Dec 27 2018
Revision requested: Feb 11 2019
Revision received: Mar 28 2019
Accepted: Apr 16 2019
Published online: June 11 2019
Published in print: Aug 2019

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Vol. 292, No. 2

Supplemental Material

Abbreviations

Abbreviations:
CI	confidence interval
ISUP	International Society of Urological Pathology
PI-RADS	Prostate Imaging Reporting and Data System
PSA	prostate-specific antigen

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