An Evolutionary Analysis of Antigen Processing and Presentation across Different Timescales Reveals Pervasive Selection
Figure 4
Analysis of positively selected sites in ERAP2.
(A) Ribbon diagram of ERAP2: positively selected sites are shown in red and those that coordinate the Zn ion (violet) in yellow. (B) Alignment of the region surrounding 416Y and 420V (in red) for a few representative mammals. (C) ΔΔG in kcal/mol for 416Y (left), 420V (right) mutations to all other 19 residues of the ERAP2 structure or sequence; results are shown for FoldX, PopMuSiC, and I-Mutant.