Pre-Frailty Phenotype and Arterial Stiffness in Older Adults Free of Cardiovascular Diseases
Abstract
:1. Introduction
2. Methods
2.1. Study Design
2.2. Participants
2.3. Fried Frailty Phenotypes
2.4. Arteral Stiffnesis and Blood Pressure
2.5. Blood Parameters and Framingham Risk Score
2.6. Other Variables
2.7. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Overall | Robust | Pre-Frail | p | |
---|---|---|---|---|
n (%) | 249 | 95 (38.2) | 154 (61.8) | |
Age, years | 66.1 ± 5.3 | 66.5 ± 5.3 | 65.9 ± 5.4 | 0.392 |
Race, n (%) | ||||
Caucasian | 89 (35.7) | 32 (33.7) | 57 (37) | 0.733 |
Brown | 138 (55.4) | 56 (58.9) | 82 (53.2) | |
Black | 17 (6.8) | 6 (6.3) | 11 (7.1) | |
Other | 5 (2) | 1 (1.1) | 5 (2.6) | |
Females, n (%) | 198 (79.5) | 74 (77.9) | 124 (80.5) | 0.618 |
Living with partner, n (%) | 159 (63.9) | 68 (71.6) | 91 (59.1) | 0.046 |
Post-secondary education, n (%) | 51 (20.5) | 16 (16.8) | 35 (22.7) | 0.264 |
Body mass index, kg/m2 | 29 ± 4.6 | 28.6 ± 4.3 | 29.2 ± 4.8 | 0.314 |
Fasting glucose, mg/dL | 111.1 ± 31.9 | 111.7 ± 36.8 | 110.8 ± 28.6 | 0.836 |
Triglycerides, md/dL | 154.3 ± 75 | 157.9 ± 98.9 | 152.1 ± 64.2 | 0.552 |
HDL-cholesterol, md/dL | 45.9 ± 12.7 | 45.3 ± 11.6 | 46.3 ± 13.3 | 0.556 |
LDL-cholesterol, md/dL | 132.4 ± 44.6 | 135 ± 47.4 | 130.8 ± 42.9 | 0.473 |
Total cholesterol, md/dL | 205.2 ± 46.7 | 205.9 ± 48.1 | 204.7 ± 46 | 0.838 |
Antihypertensive medication, n (%) | ||||
Monotherapy | 73 (48) | 30 (50.8) | 43 (46.2) | 0.579 |
Combination therapy | 79 (52) | 29 (49.2) | 50 (53.8) | 0.579 |
Calcium channel blockers | 16 (10.5) | 6 (10.2) | 10 (10.8) | 0.909 |
Diuretics | 61 (40.1) | 19 (32.2) | 42 (45.2) | 0.112 |
Angiotensin II receptor blockers | 116 (76.3) | 45 (76.3) | 71 (76.3) | 0.992 |
ACE inhibitors | 14 (9.2) | 5 (8.5) | 9 (9.7) | 0.803 |
Beta-blockers | 39 (25.7) | 20 (33.9) | 19 (20.4) | 0.064 |
Diabetes medication, n (%) | 64 (25.7) | 29 (30.5) | 35 (22.7) | 0.171 |
Lipid medication, n (%) | 80 (32.1) | 24 (25.3) | 56 (36.4) | 0.068 |
Ex-smoker/smoker, n (%) | 110 (44.2) | 40 (42.1) | 70 (45.5) | 0.605 |
Framingham risk, n (%) | ||||
Low risk | 82 (33.3) | 36 (38.3) | 46 (30.3) | 0.347 |
Moderate risk | 121 (49.2) | 41 (43.6) | 80 (52.6) | |
High risk | 43 (17.5) | 17 (18.1) | 26 (17.1) | |
Central SBP, mmHg | 121 ± 16.4 | 118.1 ± 15.8 | 122.7 ± 16.5 | 0.029 |
Central DBP, mmHg | 82.1 ± 11.4 | 80.9 ± 9.6 | 82.9 ± 12.3 | 0.174 |
Central MBP, mmHg | 95.1 ± 12.5 | 93.3 ± 11.1 | 96.2 ± 13.1 | 0.075 |
Central PP, mmHg | 38.8 ± 9.5 | 37.2 ± 9.7 | 39.8 ± 9.2 | 0.032 |
Brachial SBP, mmHg | 128.4 ± 17.4 | 125.3 ± 16.7 | 130.3 ± 17.6 | 0.027 |
Brachial DBP, mmHg | 81 ± 11.1 | 79.7 ± 9.4 | 81.8 ± 12 | 0.147 |
Brachial MBP, mmHg | 96.8 ± 12.5 | 94.9 ± 11.1 | 98 ± 13.2 | 0.058 |
Brachial PP, mmHg | 47.3 ± 11 | 45.5 ± 11.5 | 48.5 ± 10.6 | 0.043 |
Aortic pulse wave velocity, m/s | 9.6 ± 1.1 | 9.5 ± 1.1 | 9.6 ± 1.1 | 0.544 |
Standardized Fried frailty, n (%) | ||||
Low physical activity | - | - | 55 (35.7) | |
Exhaustion | - | - | 47 (30.5) | |
Weakness | - | - | 41 (26.6) | |
Unintentional weight loss | - | - | 29 (18.8) | |
Slowness | - | - | 39 (25.3) |
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Macêdo, G.A.D.; Freire, Y.A.; Browne, R.A.V.; Câmara, M.; Cabral, L.L.P.; Schwade, D.; Paulo-Pereira, R.; Silva, R.d.M.; Silva, A.M.B.; Farias-Junior, L.F.; et al. Pre-Frailty Phenotype and Arterial Stiffness in Older Adults Free of Cardiovascular Diseases. Int. J. Environ. Res. Public Health 2022, 19, 13469. https://doi.org/10.3390/ijerph192013469
Macêdo GAD, Freire YA, Browne RAV, Câmara M, Cabral LLP, Schwade D, Paulo-Pereira R, Silva RdM, Silva AMB, Farias-Junior LF, et al. Pre-Frailty Phenotype and Arterial Stiffness in Older Adults Free of Cardiovascular Diseases. International Journal of Environmental Research and Public Health. 2022; 19(20):13469. https://doi.org/10.3390/ijerph192013469
Chicago/Turabian StyleMacêdo, Geovani Araújo Dantas, Yuri Alberto Freire, Rodrigo Alberto Vieira Browne, Marcyo Câmara, Ludmila Lucena Pereira Cabral, Daniel Schwade, Ronildo Paulo-Pereira, Raíssa de Melo Silva, Alana Monteiro Bispo Silva, Luiz Fernando Farias-Junior, and et al. 2022. "Pre-Frailty Phenotype and Arterial Stiffness in Older Adults Free of Cardiovascular Diseases" International Journal of Environmental Research and Public Health 19, no. 20: 13469. https://doi.org/10.3390/ijerph192013469