In the rat, intracerebroventricular injection of synthetic ACTH (ACTH1–24, ACTH1–16) elevated plasma corticosterone levels and induced the display of excessive grooming behavior. The grooming response could be elicited in... more
In the rat, intracerebroventricular injection of synthetic ACTH (ACTH1–24, ACTH1–16) elevated plasma corticosterone levels and induced the display of excessive grooming behavior. The grooming response could be elicited in hypophysectomized rats without concommittant elevation of plasma corticosterone. In intact rats subcutaneous injection of ACTH1–24 and not of ACTH1–16-NH2 stimulated the release of adrenal corticosteroids, whereas no excessive grooming was observed. In contrast to the reduced effectiveness of a second icv injection of ACTH in inducing the behavioral response, no single-dose tolerance was observed for the effect of icv ACTH on the pituitary-adrenal system. Therefore it was concluded that two different central mechanisms underly the observed responses to the icv applied ACTH.
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Healthy cognitive aging is thought to impact most heavily on episodic memory [1]. However, changes in episodic memory prior to the age of 60 are more controversial than changes in older adults [2]. Furthermore, cognitive decline already... more
Healthy cognitive aging is thought to impact most heavily on episodic memory [1]. However, changes in episodic memory prior to the age of 60 are more controversial than changes in older adults [2]. Furthermore, cognitive decline already present in middle age may not yet manifest in behavior due to the action of neural compensation processes that preserve performance at the
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According to the skill transfer concept, people may use general technological skills to solve new problems. To test this concept, a technological transfer test was included in a randomized controlled-intervention study aimed at the causal... more
According to the skill transfer concept, people may use general technological skills to solve new problems. To test this concept, a technological transfer test was included in a randomized controlled-intervention study aimed at the causal relationship between computer use and autonomy of older adults. Older adults with and without exposure to computer training and Internet use and participants without interest in computers were administered this test. On two occasions, participants performed four daily tasks with everyday technological devices. Exposure to a novel technological challenge did not affect the efficiency of, and involvement in, other technological activities.
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Sociology, Psychology, Cognitive Science, Cognition, Aging, and 25 moreQuality of life, Treatment Outcome, Learning, Computers, Humans, Female, Male, Education Systems, Internet Use, Internet Usage, Experimental Study, Group Intervention, Clinical Sciences, Computer User Interface Design, Aged, Middle Aged, Educational Gerontology, Adult, Intervention study, Use of Tablet Computers in the Classroom, Older Adult, Internet, Social Network, Cognition disorders, and Neuropsychological Tests
Page 1. The Neurtihypí:>ph;i5is : Siruriure. Function and Cimtnri. Prn^rean in firam Research, Vn! ftfl, edittd In li.A Ci and G. Lem; (Г) /WW Eheúir Science Pubhihers BV Vasopressin-like Peptides and the Treatment of Memory Disorders... more
Page 1. The Neurtihypí:>ph;i5is : Siruriure. Function and Cimtnri. Prn^rean in firam Research, Vn! ftfl, edittd In li.A Ci and G. Lem; (Г) /WW Eheúir Science Pubhihers BV Vasopressin-like Peptides and the Treatment of Memory Disorders in Man .!. ...
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Research Interests:
Cognition, Aging, Word Learning, Memory, Learning and Memory, and 22 moreHumans, Cholesterol, Female, Male, Reaction Time, Regression Analysis, Follow-up studies, Cognitive Performance, Clinical Sciences, Aged, Middle Aged, Adult, Cognitive Function, Biotransformation, Verbal Memory, Neurobiology of Aging, Phytosterols, Cross Sectional Studies, Serum Cholesterol, Neurosciences, Normal Aging, and Psychomotor Performance
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Sociology, Psychology, Cognitive Science, Cognition, Aging, and 25 moreQuality of life, Treatment Outcome, Learning, Computers, Humans, Female, Male, Education Systems, Internet Use, Internet Usage, Experimental Study, Group Intervention, Clinical Sciences, Computer User Interface Design, Aged, Middle Aged, Educational Gerontology, Adult, Intervention study, Use of Tablet Computers in the Classroom, Older Adult, Internet, Social Network, Cognition disorders, and Neuropsychological Tests
Public education about memory was evaluated with a controlled intervention trial. Participants in group 1 (n = 273) attended a symposium covering memory-related topics and received a magazine with identical information. Group 2 (n = 141)... more
Public education about memory was evaluated with a controlled intervention trial. Participants in group 1 (n = 273) attended a symposium covering memory-related topics and received a magazine with identical information. Group 2 (n = 141) only received the magazine. Participants were nonprofessionals and professionals aged between 29 and 88. Outcome measures were knowledge about memory and subjective experience. For nonprofessionals, knowledge increment was higher in group 1 than in group 2, indicating that an objective increment in knowledge is present in nonprofessionals after attending the symposium. No knowledge change occurred in professionals. Furthermore, participants were very satisfied after both interventions, even when knowledge transfer was limited.
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... reading or memorizing information. In particular, irrelevant speech is one of the most common sources of complaint by people in a broad age range (Kjellberg, Landstrom, Tesarz, Soderberg, & Akerlund, 1996). From a theoretical ...
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Algorithms, Anterior Cingulate, Magnetic Resonance Imaging, Aging, MRI, and 17 morePrefrontal Cortex, Software, Humans, Female, Neuroimage, Voxel Based Morphometry, Male, Frontal Cortex, Aged, Middle Aged, Adult, Inferior frontal gyrus, Age effect, Reproducibility of Results, Gray Matter, Frontal Lobe, and Magnetic resonance image
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Cognitive Science, Neurology, Dementia, Cognition, Aging, and 18 moreInformation Processing, Cephalometry, Humans, Elderly People, Female, Male, Clinical Sciences, Head, Aged, Middle Aged, Cross Section, Cognitive Ability, Cognitive Function, Older Adult, Reference Values, Alzheimer Disease, Neurosciences, and Neuropsychological Tests
This paper presents a comprehensive group intervention for older adults with cognitive complaints. It offers psychoeducation about cognitive aging and contextual factors, focuses on skills and compensatory behavior, and incorporates group... more
This paper presents a comprehensive group intervention for older adults with cognitive complaints. It offers psychoeducation about cognitive aging and contextual factors, focuses on skills and compensatory behavior, and incorporates group discussion. The intervention reduced negative emotional reactions towards cognitive functioning in a controlled study in healthy women aged 60 to 75 years. Its background and content are described in detail to enable replication and large-scale implementation. Therefore, a process evaluation was carried out. The results support participants' appreciation and point to better self-evaluations after intervention. This intervention may offer a valuable contribution to public health care for older adults.
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Low folate and raised homocysteine concentrations in blood are associated with poor cognitive performance in the general population. As part of the FACIT trial to assess the effect of folic acid on markers of atherosclerosis in men and... more
Low folate and raised homocysteine concentrations in blood are associated with poor cognitive performance in the general population. As part of the FACIT trial to assess the effect of folic acid on markers of atherosclerosis in men and women aged 50–70 years with raised plasma total homocysteine and normal serum vitamin B12 at screening, we report here the findings for the secondary endpoint: the effect of folic acid supplementation on cognitive performance.Our randomised, double blind, placebo controlled study took place between November, 1999, and December, 2004, in the Netherlands. We randomly assigned 818 participants 800 μg daily oral folic acid or placebo for 3 years. The effect on cognitive performance was measured as the difference between the two groups in the 3-year change in performance for memory, sensorimotor speed, complex speed, information processing speed, and word fluency. Analysis was by intention-to-treat. This trial is registered with clinicaltrials.gov with trial number NCT00110604.Serum folate concentrations increased by 576% (95% CI 539 to 614) and plasma total homocysteine concentrations decreased by 26% (24 to 28) in participants taking folic acid compared with those taking placebo. The 3-year change in memory (difference in Z scores 0·132, 95% CI 0·032 to 0·233), information processing speed (0·087, 0·016 to 0·158) and sensorimotor speed (0·064, −0·001 to 0·129) were significantly better in the folic acid group than in the placebo group.Folic acid supplementation for 3 years significantly improved domains of cognitive function that tend to decline with age.
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Psychology, Cognitive Science, Occupational Therapy, Nonparametric Statistics, Activities of Daily Living, and 13 moreStroke, Humans, Cognitive Therapy, Male, Follow-up studies, Aged, Middle Aged, Adult, Cognitive Strategies, Transfer of Training, Neurosciences, Activity of Daily Living, and Disability Evaluation
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Psychology, Aging, Thinking, Prospective studies, Humans, and 18 moreWork, Female, Male, Cohort Study, Clinical Sciences, Aged, Middle Aged, Longitudinal Studies, Cognitive impairment, Public health systems and services research, Odds ratio, Longitudinal data, Neurobiology of Aging, Cognitive Decline, Neurosciences, Confidence Interval, Cognition disorders, and Cohort Studies
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Research Interests:
Neurology, Magnetic Resonance Imaging, Processing Speed, Prospective studies, Humans, and 18 moreElderly People, Vascular dementia, Female, Male, Reaction Time, Cognitive Process, Aged, Longitudinal Studies, White Matter Hyperintensity, Disease Progression, Cognitive Decline, Linear Regression Model, Prospective Study, Cognition disorders, Cerebral Infarction, Magnetic resonance image, Statistics as Topic, and Neuropsychological Tests
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Psychology, Cognitive Science, Magnetic Resonance Imaging, Attention, Executive Function, and 22 moreProcessing Speed, Humans, Thalamus, Female, Male, Standardisation, Aged, Middle Aged, White matter, Adult, Neuropsychologia, Short Term Memory, Long Term Memory, Attention Deficit, Memory Disorders, Mr Imaging, Neurosciences, Region of Interest, Cognition disorders, White Matter Lesions, Cerebral Infarction, and Neuropsychological Tests
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Neurology, Magnetic Resonance Imaging, Aging, Brain, Humans, and 15 moreElderly People, Female, Male, Statistical Significance, Netherlands, Aged, Prevalence, Middle Aged, White matter, Cognitive Decline, General Population, Confidence Interval, White Matter Lesions, Brain Diseases, and Magnetic resonance image
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Cognitive Science, Neurology, Aging, Atherosclerosis, Word Learning, and 30 moreCausality, Comorbidity, Processing Speed, Stroke, Brain, Prospective studies, Humans, Old Age, Female, Male, Population based study, Netherlands, Depressive Disorder, Risk factors, Clinical Sciences, Mini Mental State Examination, Geriatric Depression Scale, Cross Section, Cognitive Function, Angina pectoris, Risk Factors, Depressive Symptoms, Coronary Artery Disease, Cognitive Decline, Memory Disorders, Cerebrovascular Disorders, Neurosciences, Predictive value of tests, Cognition disorders, and Cohort Studies
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Pharmacology, Cognition, Aging, Linear models, Information Processing, and 21 moreProspective studies, Humans, Caffeine, Female, Male, Reaction Time, Choice reaction time, Health Status, Cognitive Performance, Aged, Middle Aged, Longitudinal Studies, Food habits, Adult, Cross Section, Longitudinal Study, Cognitive Function, Chi Square Distribution, Verbal Memory, Population Study, and Cognitive Decline
The aim of this prospective study was to examine whether neurocognitive performance of children aged 5–6 years distinguished children who were later diagnosed with attention deficit/hyperactivity disorder (ADHD) or “borderline ADHD” from... more
The aim of this prospective study was to examine whether neurocognitive performance of children aged 5–6 years distinguished children who were later diagnosed with attention deficit/hyperactivity disorder (ADHD) or “borderline ADHD” from children without ADHD after adjustment for behavioral measures and to examine the influence of comorbid psychopathology. Out of a general population of 1,317 children, 366 children were selected on the basis of their scores on the Child Behavior Checklist (CBCL). Eighteen months later, the parents were interviewed using a standardized child psychiatric interview: 33 children were classified as ADHD and 75 children as borderline ADHD, and there were 258 children without ADHD. Children with rated ADHD were significantly impaired on measures of visuomotor ability and working memory compared to children without ADHD after adjustment for CBCL results. The performance of borderline ADHD children was in between that of children with and without ADHD. In addition, 4 groups of children were analyzed: 9 ADHD, 24 ADHD with comorbid oppositional defiant disorder/conduct disorder (ODD/CD), 59 ODD/CD, and 274 controls. Children with rated comorbid ADHD and ODD/CD performed significantly worse on these tasks compared to children with rated ODD/CD and control children while they did not differ from ADHD children. Our results imply that neurocognitive measures can contribute to the early identification of ADHD with and without comorbid ODD/CD.